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Design, synthesis, and biological evaluation of tetrahydroisoquinolines derivatives as novel, selective PDE4 inhibitors for antipsoriasis treatment
期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2021, 卷号: 211, 页码: 20
作者:
Zhang, Rui
;
Li, Heng
;
Zhang, Xianglei
;
Li, Jian
;
Su, Haixia
收藏
  |  
浏览/下载:23/0
  |  
提交时间:2021/05/24
PDE4 inhibitors
Tetrahydroisoquinoline
Antipsoriasis
A novel bile acid analog, A17, ameliorated non-alcoholic steatohepatitis in high-fat diet-fed hamsters
期刊论文
TOXICOLOGY AND APPLIED PHARMACOLOGY, 2020, 卷号: 404, 页码: 14
作者:
Wang, Ying
;
Zhu, Yao
;
Niu, Junxing
;
Deng, Qiangqiang
;
Guo, Shimeng
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  |  
浏览/下载:60/0
  |  
提交时间:2020/12/21
Bile acid analog
NASH
TGR5
Cd36
AMPK alpha
Phytochemical and biological studies on rare and endangered plants endemic to China. Part XIV. Structurally diverse terpenoids from the twigs and needles of the endangered plant Picea brachytyla
期刊论文
PHYTOCHEMISTRY, 2020, 卷号: 169, 页码: 11
作者:
Jiang, Wei
;
Xiong, Juan
;
Zang, Yi
;
Li, Junmin
;
Osman, Ezzat E. A.
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  |  
浏览/下载:84/0
  |  
提交时间:2020/07/01
Picea brachytyla (Franch.) E.Pritz.
Pinaceae
Endangered plant
Terpenoids
Brachytylins
ATP citrate lyase (ACL)
SHP2 tyrosine phosphatase
Exploring the structural determinants of novel xanthine derivatives as A(2B) adenosine receptor antagonists: a computational study
期刊论文
JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS, 2019, 卷号: 37, 页码: 3467-3481
作者:
Yang, Yinfeng
;
Li, Yan
;
Zhou, Weiwei
;
Chen, Yaorong
;
Wu, Qian
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  |  
浏览/下载:23/0
  |  
提交时间:2019/12/02
A(2B) adenosine receptor
3D-QSAR
molecular docking
molecular dynamics
synthetic feasibility
drug design
Urea and thiourea derivatives of 3--5,6,7,8-tetrahydro-[1, 2, 4]triazolo[4,3-a]pyrazine: Synthesis, characterization, antimicrobial activity and docking studies.
期刊论文
Phosphorus, Sulfur & Silicon & the Related Elements, 2019, 卷号: Vol.194 No.9, 页码: 922-932
作者:
Mannam, Madhava Rao
;
Devineni, Subba Rao
;
Pavuluri, Chandra Mouli
;
Chamarthi, Naga Raju
;
Kottapalli, Raja Sekhara P
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  |  
浏览/下载:7/0
  |  
提交时间:2019/11/21
adenosine-5-diphosphoribose enzyme
antimicrobial activity
molecular docking
sitagliptin intermediate
structural characterization
Urea and thiourea derivatives
Synthesis and structure-activity relationships of pyrazolo-[3,4-b]pyridine derivatives as adenosine 5'-monophosphate-activated protein kinase activators
期刊论文
ARCHIV DER PHARMAZIE, 2019, 卷号: 352, 期号: 8
作者:
Zheng, Bifeng
;
Peng, Yajun
;
Wu, Weihong
;
Ma, Junlong
;
Zhang, Yuzhao
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  |  
浏览/下载:12/0
  |  
提交时间:2019/12/11
activator
AMPK
cell proliferation
molecular docking
pyrazolo[3
4-b]pyridine
Nucleoside alkaloids with anti-platelet aggregation activity from the rhizomes of Ligusticum striatum
期刊论文
2019, 卷号: 33, 期号: 10, 页码: 1399-1405
作者:
Pu, Zhong-Hui
;
Liu, Juan
;
Peng, Cheng
;
Luo, Min
;
Zhou, Qin-Mei
收藏
  |  
浏览/下载:10/0
  |  
提交时间:2020/01/03
Ligusticum striatum
nucleoside
alkaloids
adenosine derivatives
anti-platelet aggregation activity
Anticancer properties of novel pyrazole-containing biguanide derivatives with activating the adenosine monophosphate-activated protein kinase signaling pathway
期刊论文
Archiv der Pharmazie, 2019, 卷号: 352, 期号: 9, 页码: ARTN e1900075
作者:
Zhou, Sichun
;
Xu, Leichuan
;
Cao, Mengru
;
Wang, Zhiren
;
Xiao, Di
收藏
  |  
浏览/下载:8/0
  |  
提交时间:2019/12/27
AMPK
anticancer
biguanide
pyrazole-containing heterocyclic compounds
Efficient syntheses of alpha- and beta-C-nucleosides and the origin of anomeric selectivity
期刊论文
ORGANIC CHEMISTRY FRONTIERS, 2018, 卷号: 5, 期号: 12, 页码: 1992-1999
作者:
Liu, Tongchao
;
Zhu, Zhengdan
;
Ren, Huanming
;
Chen, Yabin
;
Chen, Guohua
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  |  
浏览/下载:25/0
  |  
提交时间:2019/01/08
A novel series of 4-methyl substituted pyrazole derivatives as potent glucagon receptor antagonists: Design, synthesis and evaluation of biological activities
期刊论文
BIOORGANIC & MEDICINAL CHEMISTRY, 2018, 卷号: 26, 期号: 8, 页码: 1896-1908
作者:
Shu, Shuangjie
;
Dai, Antao
;
Wang, Jiang
;
Wang, Bin
;
Feng, Yang
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  |  
浏览/下载:20/0
  |  
提交时间:2019/01/08
Pyrazole derivatives
Glucagon receptor antagonist
Docking study
Binding pocket
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