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科研机构
上海药物研究所 [11]
昆明植物研究所 [2]
高能物理研究所 [1]
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期刊论文 [14]
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2020 [3]
2019 [1]
2018 [1]
2017 [2]
2016 [2]
2014 [3]
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Synthesis and structure-activity relationship studies of LLY-507 analogues as SMYD2 inhibitors
期刊论文
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2020, 卷号: 30, 期号: 22, 页码: 5
作者:
Zhang, Bin
;
Liao, Liping
;
Wu, Fan
;
Zhang, Fengcai
;
Sun, Zhongya
收藏
  |  
浏览/下载:34/0
  |  
提交时间:2021/05/24
SMYD2 inhibitors
Thermal shift assay
Structure-activity relationships
USP28 and USP25 are downregulated by Vismodegib in vitro and in colorectal cancer cell lines
期刊论文
FEBS JOURNAL, 2020, 页码: 18
作者:
Wang, Hui
;
Meng, Qian
;
Ding, Yiluan
;
Xiong, Muya
;
Zhu, Mengying
收藏
  |  
浏览/下载:84/0
  |  
提交时间:2020/12/24
colorectal cancer
HDX-MS
inhibitor
USP25
USP28
Vismodegib
In Silico Screening-Based Discovery of Novel Inhibitors of Human Cyclic GMP-AMP Synthase: A Cross-Validation Study of Molecular Docking and Experimental Testing
期刊论文
JOURNAL OF CHEMICAL INFORMATION AND MODELING, 2020, 卷号: 60, 期号: 6, 页码: 3265-3276
作者:
Zhao, Wenfeng
;
Xiong, Muya
;
Yuan, Xiaojing
;
Li, Minjun
;
Sun, Hongbin
收藏
  |  
浏览/下载:17/0
  |  
提交时间:2020/12/24
AZD9291 inactivates the PRC2 complex to mediate tumor growth inhibition
期刊论文
ACTA PHARMACOLOGICA SINICA, 2019, 卷号: 40, 期号: 12, 页码: 1587-1595
作者:
Zhang, Kai-li
;
Shen, Qian-qian
;
Fang, Yan-fen
;
Sun, Yi-ming
;
Ding, Jian
收藏
  |  
浏览/下载:26/0
  |  
提交时间:2020/07/01
PRC2
EZH2-EED
AZD9291
miR-34a
non-canonical base pairing
Pharmacological inhibition of dihydroorotate dehydrogenase induces apoptosis and differentiation in acute myeloid leukemia cells
期刊论文
HAEMATOLOGICA, 2018, 卷号: 103, 期号: 9, 页码: 1472-1483
作者:
Wu, Dang
;
Wang, Wanyan
;
Chen, Wuyan
;
Lian, Fulin
;
Lang, Li
收藏
  |  
浏览/下载:35/0
  |  
提交时间:2019/01/08
PI-273, a Substrate-Competitive, Specific Small-Molecule Inhibitor of PI4KII alpha, Inhibits the Growth of Breast Cancer Cells
期刊论文
CANCER RESEARCH, 2017, 卷号: 77, 期号: 22, 页码: 6253-6266
作者:
Li, Jiangmei
;
Gao, Zhen
;
Zhao, Dan
;
Zhang, Lunfeng
;
Qiao, Xinhua
收藏
  |  
浏览/下载:24/0
  |  
提交时间:2019/01/08
Establishment of a reporter gene system for activity detection of hepatocyte nuclear factor 4alpha
期刊论文
Academic Journal of Second Military Medical University, 2017, 卷号: 38, 期号: 9, 页码: 1112-1118
作者:
Sun Bingjie
;
Chen Shijie
;
Deng Longfei
;
Ding Chenhong
;
Chen Fei
收藏
  |  
浏览/下载:20/0
  |  
提交时间:2019/01/08
Ninjurin 1
hepatocyte nuclear factor 4alpha
Ninjurin 1
reporter gene system
small molecular compound
CDDO-Me reveals USP7 as a novel target in ovarian cancer cells
期刊论文
Oncotarget, 2016, 卷号: 7, 期号: 47, 页码: 77096-77109
作者:
Qin, Dongjun
;
Wang, Weiwei
;
Lei, Hu
;
Luo, Hao
;
Cai, Haiyan
收藏
  |  
浏览/下载:40/0
  |  
提交时间:2017/02/14
CDDO-Me
ovarian cancer
USP7
CETSA
deubiquitinating enzymes
Momordin Ic, a new natural SENP1 inhibitor, inhibits prostate cancer cell proliferation
期刊论文
ONCOTARGET, 2016, 卷号: 7, 期号: 37, 页码: 58995-59005
作者:
Wu, Jingjing
;
Lei, Hu
;
Zhang, Jinfu
;
Chen, Xiangyun
;
Tang, Caixia
收藏
  |  
浏览/下载:38/0
  |  
提交时间:2017/01/05
Momordin Ic
SENP1
SUMOylation
proliferation
prostate cancer
Discovery of a novel inhibitor of NAD(P)(+)-dependent malic enzyme (ME2) by high-throughput screening
期刊论文
ACTA PHARMACOLOGICA SINICA, 2014, 卷号: 35, 期号: 5, 页码: 674-684
作者:
Wen, Yi
;
Xu, Lei
;
Chen, Fang-lei
;
Gao, Jing
;
Li, Jing-ya
收藏
  |  
浏览/下载:21/0
  |  
提交时间:2019/01/08
malic enzyme
ME2
inhibitor
natural product
NPD389
high-throughput screening
structure-activity relationship
enzyme kinetics
thermal shift assay
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