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CORC

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JC-010a, a novel selective SHP2 allosteric inhibitor, overcomes RTK/non-RTK-mediated drug resistance in multiple oncogene-addicted cancers 期刊论文
CANCER LETTERS, 2024, 卷号: 582, 页码: 15
作者:  Lu, Xuxiu;  Yu, Rilei;  Li, Zhen;  Yang, Mengke;  Dai, Jiajia
收藏  |  浏览/下载：4/0  |  提交时间：2024/04/07
Theoretical study and application of 2-phenyl-1,3,4-thiadiazole derivatives with optical and inhibitory activity against SHP1 期刊论文
PHYSICAL CHEMISTRY CHEMICAL PHYSICS, 2021, 页码: 14
作者:  Zhang, Chun;  Sun, Yi-Tao;  Gao, Li-Xin;  Feng, Bo;  Yan, Xue
收藏  |  浏览/下载：21/0  |  提交时间：2022/01/18
Synthesis and biological evaluation of 2,5-diaryl-1,3,4-oxadiazole derivatives as novel Src homology 2 domain-containing protein tyrosine phosphatase 2 (SHP2) inhibitors 期刊论文
BIOORGANIC CHEMISTRY, 2021, 卷号: 116, 页码: 13
作者:  Meng, Xiang-Dong;  Gao, Li-Xin;  Wang, Zhi-Jia;  Feng, Bo;  Zhang, Chun
收藏  |  浏览/下载：31/0  |  提交时间：2021/12/01
Synthesis of 5-Phenyl-1,3,4-thiadiazole Derivatives and Their Biochemical Evaluation against Src Homology 2 Domain-Containing Protein Tyrosine Phosphatase 1 (SHP1) 期刊论文
CHINESE JOURNAL OF ORGANIC CHEMISTRY, 2021, 卷号: 41, 期号: 8, 页码: 3097-3105
作者:  Yu Lijie;  Feng Bo;  Wang Zhijia;  Gao Lixin;  Zhang Chun
收藏  |  浏览/下载：242/0  |  提交时间：2021/11/04
Disrupting phosphatase SHP2 in macrophages protects mice from high-fat diet-induced hepatic steatosis and insulin resistance by elevating IL-18 levels 期刊论文
JOURNAL OF BIOLOGICAL CHEMISTRY, 2020, 卷号: 295, 期号: 31, 页码: 10842-10856
作者:  Liu, Wen;  Yin, Ye;  Wang, Meijing;  Fan, Ting;  Zhu, Yuyu
收藏  |  浏览/下载：237/0  |  提交时间：2020/12/24
Synthesis and biological evaluation of heterocyclic bis-aryl amides as novel Src homology 2 domain containing protein tyrosine phosphatase-2 (SHP2) inhibitors 期刊论文
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2020, 卷号: 30, 期号: 11, 页码: 5
作者:  Satheeshkumar, Rajendran;  Zhu, Rui;  Feng, Bo;  Huang, Chao;  Gao, Ya
收藏  |  浏览/下载：29/0  |  提交时间：2020/07/01
Phytochemical and biological studies on rare and endangered plants endemic to China. Part XIV. Structurally diverse terpenoids from the twigs and needles of the endangered plant Picea brachytyla 期刊论文
PHYTOCHEMISTRY, 2020, 卷号: 169, 页码: 11
作者:  Jiang, Wei;  Xiong, Juan;  Zang, Yi;  Li, Junmin;  Osman, Ezzat E. A.
收藏  |  浏览/下载：84/0  |  提交时间：2020/07/01
The HNF1 alpha-regulated lncRNA HNF1A-AS1 reverses the malignancy of hepatocellular carcinoma by enhancing the phosphatase activity of SHP-1 期刊论文
MOLECULAR CANCER, 2018, 卷号: 17
作者:  Ding, Chen-Hong;  Yin, Chuan;  Chen, Shi-Jie;  Wen, Liang-Zhi;  Ding, Kai
收藏  |  浏览/下载：31/0  |  提交时间：2019/01/08
6-Methoxyethylamino-numonafide inhibits hepatocellular carcinoma xenograft growth as a single agent and in combination with sorafenib 期刊论文
FASEB JOURNAL, 2017, 卷号: 31, 期号: 12, 页码: 5453-5465
作者:  Liu, Yanning;  Lou, Guohua;  Norton, John T.;  Wang, Chen;  Kandela, Irawati
收藏  |  浏览/下载：23/0  |  提交时间：2019/01/08
Benzo[c][1,2,5] thiadiazole derivatives: A new class of potent Src homology-2 domain containing protein tyrosine phosphatase-2 (SHP2) inhibitors 期刊论文
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2017, 卷号: 27, 期号: 23, 页码: 5154-5157
作者:  Wang, Wen-Long;  Chen, Xiao-Yu;  Gao, Ya;  Gao, Li-Xin;  Sheng, Li
收藏  |  浏览/下载：28/0  |  提交时间：2019/01/08

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