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上海药物研究所 [5]
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期刊论文 [12]
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Synthesis and biological evaluation of 2,5-diaryl-1,3,4-oxadiazole derivatives as novel Src homology 2 domain-containing protein tyrosine phosphatase 2 (SHP2) inhibitors
期刊论文
BIOORGANIC CHEMISTRY, 2021, 卷号: 116, 页码: 13
作者:
Meng, Xiang-Dong
;
Gao, Li-Xin
;
Wang, Zhi-Jia
;
Feng, Bo
;
Zhang, Chun
收藏
  |  
浏览/下载:30/0
  |  
提交时间:2021/12/01
2,5-diphenyl-1,3,4-oxadiazole derivatives
SHP2
Inhibitors
Structure-activity relationships (SAR)
Synthesis of 5-Phenyl-1,3,4-thiadiazole Derivatives and Their Biochemical Evaluation against Src Homology 2 Domain-Containing Protein Tyrosine Phosphatase 1 (SHP1)
期刊论文
CHINESE JOURNAL OF ORGANIC CHEMISTRY, 2021, 卷号: 41, 期号: 8, 页码: 3097-3105
作者:
Yu Lijie
;
Feng Bo
;
Wang Zhijia
;
Gao Lixin
;
Zhang Chun
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  |  
浏览/下载:195/0
  |  
提交时间:2021/11/04
5-phenyl-1,3,4-thiadiazole derivatives
Src homology 2 domain-containing protein tyrosine phosphatase 1 (SHP1)
inhibitors
structure-activity relationships
Disrupting phosphatase SHP2 in macrophages protects mice from high-fat diet-induced hepatic steatosis and insulin resistance by elevating IL-18 levels
期刊论文
JOURNAL OF BIOLOGICAL CHEMISTRY, 2020, 卷号: 295, 期号: 31, 页码: 10842-10856
作者:
Liu, Wen
;
Yin, Ye
;
Wang, Meijing
;
Fan, Ting
;
Zhu, Yuyu
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  |  
浏览/下载:191/0
  |  
提交时间:2020/12/24
Src homology 2 domain containing tyrosine phosphatase-2 (SHP2)
hepatic steatosis
insulin resistance
caspase-1
interleukin 18 (IL-18)
fatty liver
metabolic disorder
inflammation
cytokine signaling
caspase 1 (CASP1)
tyrosine-protein phosphatase (tyrosine phosphatase)
macrophage
Phytochemical and biological studies on rare and endangered plants endemic to China. Part XIV. Structurally diverse terpenoids from the twigs and needles of the endangered plant Picea brachytyla
期刊论文
PHYTOCHEMISTRY, 2020, 卷号: 169, 页码: 11
作者:
Jiang, Wei
;
Xiong, Juan
;
Zang, Yi
;
Li, Junmin
;
Osman, Ezzat E. A.
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  |  
浏览/下载:83/0
  |  
提交时间:2020/07/01
Picea brachytyla (Franch.) E.Pritz.
Pinaceae
Endangered plant
Terpenoids
Brachytylins
ATP citrate lyase (ACL)
SHP2 tyrosine phosphatase
Dietary quercetin potentiates the antiproliferative effect of interferon-alpha in hepatocellular carcinoma cells through activation of JAK/STAT pathway signaling by inhibition of SHP2 phosphatase
期刊论文
ONCOTARGET, 2017, 卷号: 8, 期号: 69, 页码: 113734-113748
作者:
Igbe, I
;
Shen, XF
;
Jiao, W
;
Qiang, Z
;
Deng, T
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  |  
浏览/下载:58/0
  |  
提交时间:2018/08/28
Quercetin
Interferon
Shp2
Jak
Stat
Ultra-deep tyrosine phosphoproteomics enabled by a phosphotyrosine superbinder
期刊论文
NATURE CHEMICAL BIOLOGY, 2016, 卷号: 12, 期号: 11, 页码: 959-+
作者:
Liu, Xuguang
;
Bian, Yangyang
;
Li, Lei
;
Dong, Mingming
;
Kaneko, Tomonori
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  |  
浏览/下载:20/0
  |  
提交时间:2019/06/20
Luteolin sensitizes the antiproliferative effect of interferon alpha/beta by activation of Janus kinase/signal transducer and activator of transcription pathway signaling through protein kinase A-mediated inhibition of protein tyrosine phosphatase SHP-2 in cancer cells
期刊论文
CELLULAR SIGNALLING, 2014, 卷号: 26, 期号: 3, 页码: 619-628
Tai, Zhengfu
;
Lin, Yuan
;
He, Yujiao
;
Huang, Junmei
;
Guo, Jiajia
;
Yang, Lijuan
;
Zhang, Guolin
;
Wang, Fei
收藏
  |  
浏览/下载:27/0
  |  
提交时间:2016/01/07
Luteolin
Interferon
Phosphodiesterase
PKA
SHP-2
HPN, a Synthetic Analogue of Bromophenol from Red Alga Rhodomela confervoides: Synthesis and Anti-Diabetic Effects in C57BL/KsJ-db/db Mice
期刊论文
MARINE DRUGS, 2013, 卷号: 11, 期号: 2, 页码: 350-362
作者:
Shi, Dayong
;
Guo, Shuju
;
Jiang, Bo
;
Guo, Chao
;
Wang, Tao
收藏
  |  
浏览/下载:28/0
  |  
提交时间:2014/07/17
bromophenol
protein tyrosine phosphatase 1B inhibitor
db/db mouse model
anti-diabetes properties
HPN, a Synthetic Analogue of Bromophenol from Red Alga Rhodomela confervoides: Synthesis and Anti-Diabetic Effects in C57BL/KsJ-db/db Mice
期刊论文
MARINE DRUGS, 2013, 卷号: 11, 期号: 2, 页码: 350-362
作者:
Shi, Dayong
;
Guo, Shuju
;
Jiang, Bo
;
Guo, Chao
;
Wang, Tao
收藏
  |  
浏览/下载:20/0
  |  
提交时间:2019/01/08
bromophenol
protein tyrosine phosphatase 1B inhibitor
db/db mouse model
anti-diabetes properties
Suppressor of cytokine signaling 3 inhibits head kidney macrophage activation and cytokine expression in Scophthalmus maximus
期刊论文
DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY, 2011, 卷号: 35, 期号: 2, 页码: 174-181
作者:
Zhang, Min
;
Xiao, Zhi-zhong
;
Sun, Li
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  |  
浏览/下载:14/0
  |  
提交时间:2012/07/03
Suppressor of cytokine signaling
Scophthalmus maximus
Macrophage
Innate immune response
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