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期刊论文 [39]
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Adaptive resistance to PI3K alpha-selective inhibitor CYH33 is mediated by genomic and transcriptomic alterations in ESCC cells
期刊论文
CELL DEATH & DISEASE, 2021, 卷号: 12, 期号: 1, 页码: 13
作者:
Wang, Yu-xiang
;
Zhang, Xu
;
Ma, Qing-yang
;
Hu, Lan-dian
;
Zhang, Xi
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  |  
浏览/下载:47/0
  |  
提交时间:2021/05/24
Emerging roles of class I PI3K inhibitors in modulating tumor microenvironment and immunity
期刊论文
ACTA PHARMACOLOGICA SINICA, 2020, 页码: 8
作者:
Sun, Pu
;
Meng, Ling-hua
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  |  
浏览/下载:39/0
  |  
提交时间:2020/12/21
phosphoinositide 3-kinase (PI3K)
PI3K inhibitors
tumor microenvironment
immune cells
immunotherapy
Endosulfan promotes cell migration via PTP4A3-mediated signaling pathways in HUVECs
期刊论文
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY, 2020, 卷号: 192, 页码: 1-9
作者:
Li, Heng
;
Liu, Shiqi
;
Hu, Yumeng
;
Zhao, Bin
;
Sun, Yeqing
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  |  
浏览/下载:24/0
  |  
提交时间:2021/09/14
Endosulfan
Cell migration
PTP4A3
Signaling pathway
Endothelial cells
Chemical Composition and Biological Activities of Endophytic Fungus Talaromyces Wortmannii LGT-4, Cultured in CYM Medium
期刊论文
IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH, 2020, 卷号: 19, 期号: 2, 页码: 259-263
作者:
Yang, Zhong-Duo
;
Zhang, Yu
;
Zhao, Wei-Hua
;
Shu, Zong-Mei
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  |  
浏览/下载:7/0
  |  
提交时间:2022/03/01
Endophytic fungus
Monoamine oxidase inhibitors
Chemical composition
Talaromyces wortmannii
Tripterygium wilfordi
Design, synthesis, and biological evaluation of thieno[3,2-d]pyrimidine derivatives as potential simplified phosphatidylinositol 3-kinase alpha inhibitors
期刊论文
CHEMICAL BIOLOGY & DRUG DESIGN, 2019, 卷号: 94, 期号: 6, 页码: 2013-2022
作者:
Yang, Xiuyan
;
Deng, Meng
;
Zhang, Xi
;
Wang, Yi
;
Song, Kun
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  |  
浏览/下载:75/0
  |  
提交时间:2020/07/01
PI3K alpha inhibitors
proliferation inhibition
thieno[3
2-d]pyrimidine derivatives
Wortmannine F and G, two new pyranones from Talaromyces wortmannii LGT-4, the endophytic fungus of Tripterygium wilfordii
期刊论文
PHYTOCHEMISTRY LETTERS, 2019, 卷号: 29, 页码: 115-118
作者:
Zhao, Jun-Wen
;
Yang, Zhong-Duo
;
Zhou, Shuan-Yan
;
Yang, Li-Jun
;
Sun, Jian-Hui
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  |  
浏览/下载:7/0
  |  
提交时间:2019/11/15
Wortmannine
Talaromyces wortmannii
Endophytic fungus
Phosphoinositide 3-kinase inhibitors
Wortmannine F and G, two new pyranones from Talaromyces wortmannii LGT-4, the endophytic fungus of Tripterygium wilfordii
期刊论文
PHYTOCHEMISTRY LETTERS, 2019, 卷号: 29, 页码: 115-118
作者:
Zhao, Jun-Wen
;
Yang, Zhong-Duo
;
Zhou, Shuan-Yan
;
Yang, Li-Jun
;
Sun, Jian-Hui
收藏
  |  
浏览/下载:6/0
  |  
提交时间:2022/03/01
Wortmannine
Talaromyces wortmannii
Endophytic fungus
Phosphoinositide 3-kinase inhibitors
Structure‐based pharmacophore models to probe anticancer activity of inhibitors of protein kinase B‐beta (PKB β).
期刊论文
Chemical Biology & Drug Design, 2019, 卷号: Vol.93 No.3, 页码: 325-336
作者:
Akhtar, N.a
;
Jabeen, I.a
;
Jalal, N.b
;
Antilla, J.b
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  |  
浏览/下载:16/0
  |  
提交时间:2019/11/21
Akt
ligand–protein interactions
phosphoinositide 3‐kinase
quinoline‐type inhibitors
structure‐based pharmacophore modeling
virtual screening
High-throughput screening campaigns against a PI3K alpha isoform bearing the H1047R mutation identified potential inhibitors with novel scaffolds
期刊论文
ACTA PHARMACOLOGICA SINICA, 2018, 卷号: 39, 期号: 11, 页码: 1816-1822
作者:
Wang, Jia
;
Gong, Grace Qun
;
Zhou, Yan
;
Lee, Woo-Jeong
;
Buchanan, Christina Maree
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  |  
浏览/下载:84/0
  |  
提交时间:2019/01/08
high throughput screening
PI3 kinase
PI3K alpha H1047R
inhibitors
molecular modeling
Synthesis, biological evaluation and structure-activity relationship of a novel class of PI3K alpha H1047R mutant inhibitors
期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2018, 卷号: 158, 页码: 707-719
作者:
Zhang, Ning
;
Yu, Zhimei
;
Yang, Xiaohong
;
Zhou, Yan
;
Wang, Jia
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  |  
浏览/下载:84/0
  |  
提交时间:2019/01/08
Anticancer drug
Phosphatidylinositol 3-kinase
Structure-activity relationship
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