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上海药物研究所 [9]
昆明医科大学 [3]
昆明植物研究所 [2]
大连化学物理研究所 [1]
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期刊论文 [16]
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Enhanced Anti-diabetic Effect of Berberine Combined With Timosaponin B2 in Goto-Kakizaki Rats, Associated With Increased Variety and Exposure of Effective Substances Through Intestinal Absorption
期刊论文
FRONTIERS IN PHARMACOLOGY, 2019, 卷号: 10, 页码: 15
作者:
Tian, Xiaoting
;
Liu, Fang
;
Li, Zhixiong
;
Lin, Yunfei
;
Liu, Huan
收藏
  |  
浏览/下载:18/0
  |  
提交时间:2020/07/01
berberine
timosaponin B2
diabetes
combination treatments
drug-drug interaction
metabolites
hepatic metabolism
intestinal absorption
Dual actions of norathyriol as a new candidate hypouricaemic agent: uricosuric effects and xanthine oxidase inhibition
期刊论文
EUROPEAN JOURNAL OF PHARMACOLOGY, 2019, 卷号: 853
作者:
Lin, Hua
;
Tu, Caixia
;
Niu, Yanfen
;
Li, Fashuang
;
Yuan, Lixian
收藏
  |  
浏览/下载:21/0
  |  
提交时间:2019/12/04
Norathyriol
Hyperuricaemia
Uricosuric effect
Renal urate transporter
Organic anion transporter 1
Xanthine oxidase
Discovery of potent PTP1B inhibitors via structure-based drug design, synthesis and in vitro bioassay of Norathyriol derivatives
期刊论文
2019, 卷号: 86, 页码: 224-234
作者:
Xue, Wenjie
;
Tian, Jinlong
;
Wang, Xiang Simon
;
Xia, Jie
;
Wu, Song
收藏
  |  
浏览/下载:11/0
  |  
提交时间:2020/01/03
PTP1B inhibitors
Structure-based drug design
Molecular docking
Norathyriol
Metabolism, pharmacokinetics, and hepatic disposition of xanthones and saponins on Zhimu treatments for exploratively interpreting the discrepancy between the herbal safety and timosaponin A3-induced hepatotoxicity
期刊论文
Acta pharmacologica Sinica, 2018, 卷号: 39, 期号: 12, 页码: 1923-1934
作者:
Xie, Yang
;
Zhou, Xu
;
Pei, Hu
;
Chen, Ming-Cang
;
Sun, Zhao-Lin
收藏
  |  
浏览/下载:93/0
  |  
提交时间:2019/01/08
Absorption, Metabolism, and Pharmacokinetics Profiles of Norathyriol, an Aglycone of Mangiferin, in Rats by HPLC-MS/MS
期刊论文
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 2018, 卷号: 66, 期号: 46, 页码: 12227-12235
作者:
Guo, Xiaozhen
;
Cheng, Mingcang
;
Hu, Pei
;
Shi, Zhangpeng
;
Chen, Shuoji
收藏
  |  
浏览/下载:266/0
  |  
提交时间:2019/01/08
norathyriol
pharmacokinetics
bioavailability
metabolism
HPLC-MS/MS
metabolismpharmacokineticsandhepaticdispositionofxanthonesandsaponinsonzhimutreatmentsforexplorativelyinterpretingthediscrepancybetweentheherbalsafetyandtimosaponina3inducedhepatotoxicity
期刊论文
actapharmacologicasinica, 2018, 卷号: 39, 期号: 12, 页码: 1923
作者:
Xie Yang
;
Zhou Xu
;
Pei Hu
;
Chen Mingcang
;
Sun Zhaolin
收藏
  |  
浏览/下载:5/0
  |  
提交时间:2020/07/01
B-II
LIVER-INJURY
IN-VITRO
ANEMARRHENA-ASPHODELOIDES
OXIDATIVE STRESS
RAT PLASMA
A-III
MANGIFERIN
NORATHYRIOL
EXTRACT
Zhimu
timosaponin A3
mangiferin
pharmacokinetics
metabolism
hepatotoxicity
antioxidant
Hypouricaemic action of mangiferin results from metabolite norathyriol via inhibiting xanthine oxidase activity
期刊论文
PHARMACEUTICAL BIOLOGY, 2016, 卷号: 54, 期号: 9, 页码: 1680-1686
作者:
Niu, Yanfen
;
Liu, Jia
;
Liu, Hai-Yang
;
Gao, Li-Hui
;
Feng, Guo-Hua
收藏
  |  
浏览/下载:25/0
  |  
提交时间:2017/01/05
Active metabolite
hyperuricaemia
structure-activity relationship
uric acid production
Pharmacokinetics of mangiferin and its metabolite-Norathyriol, Part 1: Systemic evaluation of hepatic first-pass effect in vitro and in vivo
期刊论文
BIOFACTORS, 2016, 卷号: 42, 期号: 5, 页码: 533-544
作者:
Tian, Xiaoting
;
Gao, Yu
;
Xu, Zhou
;
Lian, Shan
;
Ma, Yuanjie
收藏
  |  
浏览/下载:24/0
  |  
提交时间:2019/01/08
mangiferin
norathyriol
pharmacokinetics
metabolism
liver
Pharmacokinetics of mangiferin and its metabolite-Norathyriol, Part 2: Influence of UGT, CYP450, P-gp, and enterobacteria and the potential interaction in Rhizoma Anemarrhenae decoction with timosaponin B2 as the major contributor
期刊论文
BIOFACTORS, 2016, 卷号: 42, 期号: 5, 页码: 545-555
作者:
Tian, Xiaoting
;
Xu, Zhou
;
Li, Zhixiong
;
Ma, Yuanjie
;
Lian, Shan
收藏
  |  
浏览/下载:27/0
  |  
提交时间:2019/01/08
mangiferin
norathyriol
pharmacokinetics
drug-drug interaction
timosaponin B2
Rhizoma Anemarrhenae
Hypouricaemic action of mangiferin results from metabolite norathyriol via inhibiting xanthine oxidase activity
期刊论文
PHARMACEUTICAL BIOLOGY, 2016, 卷号: 54, 期号: 9
作者:
Li, Ling
;
Niu, Yanfen
;
Liu, Jia
;
Liu, Hai-Yang
;
Gao, Li-Hui
收藏
  |  
浏览/下载:7/0
  |  
提交时间:2019/12/04
Active metabolite
hyperuricaemia
structure-activity relationship
uric acid production
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