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Novel tetrahydrobenzo[b]thiophen-2-yl)urea derivatives as novel alpha-glucosidase inhibitors: Synthesis, kinetics study, molecular docking, and in vivo anti-hyperglycemic evaluation
期刊论文
BIOORGANIC CHEMISTRY, 2021, 卷号: 115, 页码: 17
作者:
Xie, Hong-Xu
;
Zhang, Juan
;
Li, Yue
;
Zhang, Jin-He
;
Liu, Shan-Kui
收藏
  |  
浏览/下载:68/0
  |  
提交时间:2021/11/04
Tetrahydrobenzo[b]thiophen-2-yl)urea
alpha-Glucosidase inhibitors
Non-competitive inhibitor
Molecular docking
Anti-hyperglycaemic activity
Type 2 diabetes
Polyoxypregnanes as safe, potent, and specific ABCB1-inhibitory pro-drugs to overcome multidrug resistance in cancer chemotherapy in vitro and in vivo
期刊论文
ACTA PHARMACEUTICA SINICA B, 2021, 卷号: 11, 期号: 7, 页码: 1885-1902
作者:
Wu, Xu
;
Yin, Chun
;
Ma, Jiang
;
Chai, Stella
;
Zhang, Chunyuan
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  |  
浏览/下载:38/0
  |  
提交时间:2021/11/04
Multidrug resistance
ABCB1
Polyoxypregnane
Combination chemotherapy
Marsdenia tenacissima
Nitrate on localized corrosion of carbon steel and stainless steel in aqueous solutions
期刊论文
ELECTROCHIMICA ACTA, 2021, 卷号: 369, 页码: 13
作者:
Xu, Weichen
;
Zhang, Binbin
;
Deng, Yu
;
Yang, Lihui
;
Zhang, Jie
收藏
  |  
浏览/下载:20/0
  |  
提交时间:2021/04/14
An Aggregation-induced Emission Probe Based on Host-Guest Inclusion Composed of the Tetraphenylethylene Motif and gamma-Cyclodextrin for the Detection of alpha-Amylase
期刊论文
CHEMISTRY-AN ASIAN JOURNAL, 2019, 卷号: 14, 期号: 6, 页码: 847-852
作者:
Tang, Bo
;
Li, Lu
;
Shangguan, Huijuan
;
Wan, Chuyun
;
Chai, Zhaofei
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  |  
浏览/下载:86/0
  |  
提交时间:2019/06/24
aggregation-induced emission
fluorescence
fluorescent probes
host-guest systems
alpha-amylase
Potential Pharmacokinetic Drug-Drug Interaction Between Harmine, a Cholinesterase Inhibitor, and Memantine, a Non-Competitive N-Methyl-d-Aspartate Receptor Antagonist
期刊论文
MOLECULES, 2019, 卷号: 24, 期号: 7
作者:
Zhang, Yunpeng
;
Li, Shuping
;
Wang, Youxu
;
Deng, Gang
;
Cao, Ning
收藏
  |  
浏览/下载:24/0
  |  
提交时间:2019/12/05
harmine
memantine
drug-drug interaction
pharmacokinetics
Alzheimer's disease
liquid chromatography-mass spectrometry
Suppressor of cytokine signalling-2 limits igf1r-mediated regulation of epithelial-mesenchymal transition in lung adenocarcinoma
期刊论文
Cell death & disease, 2018, 卷号: 9, 页码: 14
作者:
Zhou, Yue
;
Zhang, Zhilei
;
Wang, Ning
;
Chen, Jizheng
;
Zhang, Xu
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  |  
浏览/下载:78/0
  |  
提交时间:2019/05/08
Detection of PRMT1 inhibitors with stopped flow fluorescence
期刊论文
Signal transduction and targeted therapy, 2018, 卷号: 3, 页码: 6
作者:
Qian, Kun
;
Hu, Hao
;
Xu, Hui
;
Zheng, Y George
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  |  
浏览/下载:59/0
  |  
提交时间:2019/01/08
Design, synthesis and biological evaluation of uncharged catechol derivatives as selective inhibitors of PTP1B
期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2017, 卷号: 136, 页码: 348-359
作者:
Li, Xiang-Qian
;
Xu, Qi
;
Luo, Jiao
;
Wang, Li-Jun
;
Jiang, Bo
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  |  
浏览/下载:24/0
  |  
提交时间:2017/10/09
Type 2 Diabetes
Ptp1b Inhibition
Selectivity
Competitive
Cellular Activity
LX2343 alleviates cognitive impairments in AD model rats by inhibiting oxidative stress-induced neuronal apoptosis and tauopathy
期刊论文
ACTA PHARMACOLOGICA SINICA, 2017, 卷号: 38, 期号: 8, 页码: 1104-1119
作者:
Guo, Xiao-dan
;
Sun, Guang-long
;
Zhou, Ting-ting
;
Wang, Yi-yang
;
Xu, Xin
收藏
  |  
浏览/下载:36/0
  |  
提交时间:2019/01/08
Alzheimer's disease
LX2343
cognitive deficits
oxidative stress
tauopathy
mitochondria
GSK-3 beta inhibitor
neuroprotection
ICV-STZ rats
Marine-derived chromopeptide A, a novel class I HDAC inhibitor, suppresses human prostate cancer cell proliferation and migration
期刊论文
ACTA PHARMACOLOGICA SINICA, 2017, 卷号: 38, 期号: 4, 页码: 551-560
作者:
Sun, Jing-ya
;
Wang, Ji-dong
;
Wang, Xin
;
Liu, Hong-chun
;
Zhang, Min-min
收藏
  |  
浏览/下载:42/0
  |  
提交时间:2019/01/08
HDAC
chromopeptide A
FK228
human prostate cancer
cell cycle arrest
apoptosis
cancer cell migration
PC3 xenograft model
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