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上海药物研究所 [9]
大连理工大学 [4]
大连化学物理研究所 [3]
兰州大学 [2]
山东大学 [2]
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期刊论文 [23]
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Identification and Analysis of Novel Inhibitors against NS3 Helicase and NS5B RNA-Dependent RNA Polymerase from Hepatitis C Virus 1b (Con1)
期刊论文
FRONTIERS IN MICROBIOLOGY, 2017, 卷号: 8
作者:
Yang, Na
;
Sun, Chaomin
;
Zhang, Lixin
;
Liu, Jianguo
;
Song, Fuhang
收藏
  |  
浏览/下载:31/0
  |  
提交时间:2018/01/11
Hepatitis c Virus
Ns3 Helicase
Ns5b Rna-dependent Rna Polymerase
High Throughput
Inhibitor
Synthesis, biological evaluation and molecular modeling of 2-Hydroxyisoquinoline-1,3-dione analogues as inhibitors of HIV reverse transcriptase associated ribonuclease H and polymerase
期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2017, 卷号: 133, 页码: 85-96
作者:
Tang, Jing
;
Vernekar, Sanjeev Kumar V.
;
Chen, Yue-Lei
;
Miller, Lena
;
Huber, Andrew D.
收藏
  |  
浏览/下载:20/0
  |  
提交时间:2019/01/08
2-hydroxyisoquinoline-1,3-diones
HIV
RNase H
Reverse transcriptase
Inhibitor
3D-QSAR and molecular docking studies on designing inhibitors of the hepatitis C virus NS5B polymerase
期刊论文
JOURNAL OF MOLECULAR STRUCTURE, 2016, 卷号: 1117, 页码: 227-239
作者:
Li, WL
;
Si, HZ
;
Li, Y
;
Ge, CZ
;
Song, FC
收藏
  |  
浏览/下载:5/0
  |  
提交时间:2017/01/12
Hepatitis C virus (HCV)
NS5B polymerase inhibitors
QSAR
COMSIA
Molecular docking
Structure-based optimization and derivatization of 2-substituted quinolone-based non-nucleoside HCV NS5B inhibitors with submicromolar cellular replicon potency
期刊论文
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2016, 卷号: 26, 期号: 12, 页码: 2900-2906
作者:
Cheng, Yu
;
Shen, Jian
;
Peng, Run-Ze
;
Wang, Gui-Feng
;
Zuo, Jian-Ping
收藏
  |  
浏览/下载:27/0
  |  
提交时间:2019/01/08
HCV NS5B polymerase
2-Alkyl quinolone
1,6-Naphthyridine-4,5-dione
Non-nucleoside inhibitor
Direct acting antiviral
Allosteric site
Discovery of Novel Hepatitis C Virus NS5B Polymerase Inhibitors by Combining Random Forest, Multiple e-Pharmacophore Modeling and Docking.
期刊论文
PLoS One, 2016, 卷号: Vol.11 No.2, 页码: e0148181
作者:
Yu Wei
;
Jinlong Li
;
Jie Qing
;
Mingjie Huang
;
Ming Wu
收藏
  |  
浏览/下载:4/0
  |  
提交时间:2019/02/27
Nucleoside Inhibitors of Hepatitis C Virus NS5B Polymerase: A Systematic Review
期刊论文
CURRENT DRUG TARGETS, 2016, 卷号: 17, 期号: 13, 页码: 1560-1576
作者:
Xie, Yuanchao
;
Ogah, Comfort Alicha
;
Jiang, Xiangrui
;
Li, Jianfeng
;
Shen, Jingshan
收藏
  |  
浏览/下载:13/0
  |  
提交时间:2019/01/08
Hepatitis C virus
inhibitor
nucleoside
NS5B polymerase
prodrug
SAR
Multiple ligand detection and affinity measurement by ultrafiltration and mass spectrometry analysis applied to fragment mixture screening
期刊论文
ANALYTICA CHIMICA ACTA, 2015, 卷号: 886, 页码: 98-106
作者:
Qin, Shanshan
;
Ren, Yiran
;
Fu, Xu
;
Shen, Jie
;
Chen, Xin
收藏
  |  
浏览/下载:39/0
  |  
提交时间:2016/06/23
Ultrafiltration-LC/MS
Multiple ligand detection
Affinity measurement
Fragment library screening
NS5B
Recent advances on the synthesis of hepatitis C virus NS5B RNA-dependent RNA-polymerase inhibitors
期刊论文
European Journal of Medicinal Chemistry: Chimie Therapeutique, 2015, 页码: 188-214
作者:
Zhao, Can
;
Wang, Yinhu
;
Ma, Shutao
收藏
  |  
浏览/下载:7/0
  |  
提交时间:2019/12/17
Hepatitis C
NS5B polymerase
Inhibitors
Antiviral therapy
Synthesis
Biological activity
Recent advances on the synthesis of hepatitis C virus NS5B RNA-dependent RNA-polymerase inhibitors
期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2015, 卷号: 102, 页码: 188-214
作者:
Zhao, Can
;
Wang, Yinhu
;
Ma, Shutao
收藏
  |  
浏览/下载:7/0
  |  
提交时间:2019/12/17
Hepatitis C
NS5B polymerase
Inhibitors
Antiviral therapy
Synthesis
Biological activity
2-Aryl-3-carbonylquinolones: Design, Synthesis and Biological Evaluation of Novel HCV NS5B Polymerase Inhibitors
期刊论文
ACTA CHIMICA SINICA, 2014, 卷号: 72, 期号: 8, 页码: 906-913
作者:
Wang Shenfeng
;
Lin Jianping
;
He Peilan
;
Zuo Jianping
;
Long Yaqiu
收藏
  |  
浏览/下载:12/0
  |  
提交时间:2019/01/08
HCV NS5B polymerase
2-substituted quinolone-3-carboxylic acid
non-nucleoside inhibitor
direct acting antiviral
allosteric site
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