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上海药物研究所 [17]
北京大学 [9]
山东大学 [8]
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期刊论文 [60]
专利 [6]
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学位论文 [3]
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Novel eIF4E/eIF4G protein-protein interaction inhibitors DDH-1 exhibits anti-cancer activity in vivo and in vitro
期刊论文
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES, 2020, 卷号: 160, 页码: 496-505
作者:
Wang, Jun
;
Wang, Lijun
;
Zhang, Shuhong
;
Fan, Junting
;
Yang, Hui
收藏
  |  
浏览/下载:56/0
  |  
提交时间:2020/10/26
eIF4E/eIF4G
Human lung cancer
Apoptosis
DNA damage
ROS
Inhibitory Effect of Metalloproteinase Inhibitors on Skin Cell Inflammation Induced by Jellyfish Nemopilema nomurai Nematocyst Venom
期刊论文
TOXINS, 2019, 卷号: 11, 期号: 3, 页码: 12
作者:
Li, Aoyu
;
Yu, Huahua
;
Li, Rongfeng
;
Liu, Song
;
Xing, Ronge
收藏
  |  
浏览/下载:66/0
  |  
提交时间:2019/08/28
Nemopilema nomurai nematocyst venom (NnNV)
jellyfish dermatitis
matrix metalloproteinases (MMPs)
inflammatory factors
skin cells
Design, synthesis and preliminary bioactivity evaluations of 8-hydroxyquinoline derivatives as matrix metalloproteinase (MMP) inhibitors
期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2019, 卷号: 181
作者:
Chen, Chen
;
Yang, Xinying
;
Fang, Hao
;
Hou, Xuben
收藏
  |  
浏览/下载:12/0
  |  
提交时间:2019/12/11
8-Hydroxyquinoline
MMP-2/9 inhibitors
Anti-migration/invasion
Anti-angiogenesis
Viridicatol and viridicatin isolated from a shark-gill-derived fungus Penicillium polonicum AP2T1 as MMP-2 and MMP-9 inhibitors in HT1080 cells by MAPKs signaling pathway and docking studies
期刊论文
2019, 卷号: 28, 期号: 7, 页码: 1039
作者:
Liang, Peng[1]
;
Zhang, Yuan Yuan[1]
;
Yang, Ping[2]
;
Grond, Stephanie[3]
;
Zhang, Yi[2,4]
收藏
  |  
浏览/下载:3/0
  |  
提交时间:2019/12/26
Synthesis and biological evaluation of novel benzofuroxan-based pyrrolidine hydroxamates as matrix metalloproteinase inhibitors with nitric oxide releasing activity
期刊论文
BIOORGANIC & MEDICINAL CHEMISTRY, 2018, 卷号: 26, 期号: 15, 页码: 4363-4374
作者:
Zhang, Hao
;
Wang, Xuejian
;
Mao, Jing
;
Huang, Yongxue
;
Xu, Wenfang
收藏
  |  
浏览/下载:2/0
  |  
提交时间:2019/12/11
MMP inhibitor
Nitric oxide
Benzofuroxan
Multifunctional drugs
Synthesis
Structural analysis and insight into novel MMP-13 inhibitors from natural chemiome as disease-modifying osteoarthritis drugs
期刊论文
2018, 卷号: 17, 期号: 11, 页码: 2255
作者:
Xiang, Yang[1]
;
Li, Yuanhui[1]
;
Ling, Zhirong[1]
;
Cheng, Yanzi[2]
收藏
  |  
浏览/下载:3/0
  |  
提交时间:2019/12/13
Gelatinase inhibitors: a patent review (2011-2017)
期刊论文
EXPERT OPINION ON THERAPEUTIC PATENTS, 2018, 卷号: 28, 期号: 1, 页码: 31-46
作者:
Li, Xun
收藏
  |  
浏览/下载:8/0
  |  
提交时间:2019/12/11
MMP
gelatinase inhibitor
isoform selectivity
binding mode
drug
design strategy
Selective MMP-13 inhibitors: promising agents for the therapy of Osteoarthritis.
期刊论文
Current medicinal chemistry, 2018
作者:
Wan Yichao
;
Li Wei
;
Liao Zhipeng
;
Yan Mi
;
Chen Xuwang
收藏
  |  
浏览/下载:9/0
  |  
提交时间:2019/12/26
MMP-13
Osteoarthritis
articular
cartilage
selective
inhibitors
structure-activity
relationship
zinc-binding
group
Expression of MMP-2 and TIMP-1 during rapid maxillary expansion in rats
期刊论文
ARCHIVES OF ORAL BIOLOGY, 2017, 卷号: 76
作者:
Chen, Jianwei
;
Zhou, Jing
;
Li, Fan
;
Sun, Jianfeng
;
Li, Guifeng
收藏
  |  
浏览/下载:2/0
  |  
提交时间:2019/12/04
Matrix metalloproteinase
Tissue inhibitors of metalloproteinase
Midpalatal suture
Tensile force
Bone remodeling
Combination of metformin with chemotherapeutic drugs via different molecular mechanisms
期刊论文
Cancer Treatment Reviews, 2017, 卷号: 54, 页码: 24-33
作者:
Peng, Mei*
;
Darko, Kwame Oteng
;
Tao, Ting
;
Huang, Yanjun
;
Su, Qiongli
收藏
  |  
浏览/下载:14/0
  |  
提交时间:2019/12/03
AIs
aromatase inhibitors
AMPK
Adenosine Monophosphate-Activated Protein Kinase
AR
androgen
ATM
Ataxia Telangiectasia Mutated
ATP
Adenosine Triphosphate
BCSS
breast cancer specific survival
CK-MB
Creatine Kinase-MB
CREB1
cAMP Response Element-Binding Protein 1
CSC
cancer stem cell
DFS
disease-free survival
DHFU
dihydrofluorouracil
DPD
dihydropyrimidine dehydrogenase
EpCAM
Epithelial Cell Adhesion Molecule
ER
estrogen
ERCC1
excision repair cross-complementary 1
ERK
extracellular signal-regulated kinases
EZH2
enhancer of zeste homolog 2
FdUMP
fluorodeoxyuridine monophosphate
FdUTP
fluorodeoxyuridine triphosphate
FHC
ferritin heavy chain
FUTP
fluorouridine triphosphate
HbA1C
hemoglobin A1c
HER
Human Epidermal Growth Factor Receptor
HIF-1α
hypoxia-inducible factor-1α
HK
hexokinase
IGF1R
insulin growth factor 1 receptor
LDH
lactate dehydrogenase
MDA
Muscular Dystrophy Association
MMP
Matrix Metallopeptidase
MRP1
multidrug resistance-associated protein 1
mTOR
mammalian target of rapamycin
MTX
methotrexate
NCCN
National Comprehensive Cancer Network
OS
overall survival
pCR
Pathologic Complete Response
PDGFR
platelet-derived growth factor receptors
PFS
progression-free survival
PKA
protein kinase A
PR
progesterone receptor
RFS
relapse-free survival
SOD
superoxide dismutase
TAM
tamoxifen
TCA
tricarboxlic acid
TS
thymidylate synthase
Combination
Mechanisms
Metformin
Chemotherapeutic drugs
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