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Oridonin inhibits DNMT3A R882 mutation-driven clonal hematopoiesis and leukemia by inducing apoptosis and necroptosis
期刊论文
CELL DEATH DISCOVERY, 2021, 卷号: 7, 期号: 1, 页码: 12
作者:
Liao, Min
;
Dong, Qiongye
;
Chen, Ruiqing
;
Xu, Liqian
;
Jiang, Yuxuan
收藏
  |  
浏览/下载:33/0
  |  
提交时间:2021/12/01
CAMKs support development of acute myeloid leukemia
期刊论文
JOURNAL OF HEMATOLOGY & ONCOLOGY, 2018, 卷号: 11, 页码: 30
作者:
Kang, Xunlei
;
Cui, Changhao
;
Wang, Chen
;
Wu, Guojin
;
Chen, Heyu
收藏
  |  
浏览/下载:10/0
  |  
提交时间:2019/12/02
Acute myeloid leukemia
CAMK
PirB
LILRB2
CREB
Leukemic stem cell
Niche TWIST1 is critical for maintaining normal hematopoiesis and impeding leukemia progression
期刊论文
2018, 卷号: 103, 期号: 12, 页码: 1969-1979
作者:
Liu, Xiaoyan
;
Ma, Yanping
;
Li, Rongrong
;
Guo, Dan
;
Wang, Nan
收藏
  |  
浏览/下载:7/0
  |  
提交时间:2020/01/03
Acute Myeloid Leukemia
Bone Marrow Microenvironment
Hematopoietic Stem Cell
Leukemic Stem Cell
EpCAM Inhibition Sensitizes Chemoresistant Leukemia to Immune Surveillance
期刊论文
CANCER RESEARCH, 2017, 卷号: 77, 期号: 2, 页码: 482-493
作者:
Zheng, Xiaohu
;
Fan, Xiaolei
;
Fu, Binqing
;
Zheng, Meijuan
;
Zhang, Aimei
收藏
  |  
浏览/下载:38/0
  |  
提交时间:2018/07/04
Systematic computation with functional gene-sets among leukemic and hematopoietic stem cells reveals a favorable prognostic signature for acute myeloid leukemia
期刊论文
BMC BIOINFORMATICS, 2015, 卷号: 16, 期号: 1, 页码: 97-97
作者:
Yang, XH
;
Li, MY
;
Wang, B
;
Zhu, WQ
;
Desgardin, A
收藏
  |  
浏览/下载:26/0
  |  
提交时间:2015/07/22
Functional gene-set
Dynamic network biomarker
Relative effect analysis
Leukemic stem cell
AML outcome
Epigenetic targets and drug discovery Part 2: Histone demethylation and DNA methylation
期刊论文
Pharmacology and Therapeutics, 2015, 卷号: 151, 页码: 121-140
作者:
Liu, Ke
;
Liu, Yanli
;
Lau, Johnathan L
;
Min, Jinrong*
收藏
  |  
浏览/下载:13/0
  |  
提交时间:2019/12/23
Histone demethylation
DNA methylation
Inhibitor
Chemical probe
Drug discovery
LSD
lysine-specific histone demethylase
HDAC
histone deacetylase
REST
REST corepressor
DNMT
DNA methyltransferase
MAO
monoamine oxidase
AML
acute myeloid leukemia
KDM
lysine-specific demethylase
MLL
mixed lineage leukemia
FAD
flavin adenine dinucleotide
PCPA
trans-2-phenylcyclopropylamine
2,4-PDCA
2, 4-pyridinedicarboxylic acid
PHD
plant homeobox domain
SCLC
small cell lung cancer
JHDMs
JmjC-domain-containing histone demethylases
NOG
N-oxalylglycine
IOX1
5-carboxy-8-hydroxyquinoline
MDS
myelodysplastic syndrome
2-OG, 2-oxoglutarate or
α-ketoglutarate
G9a
euchromatic histone-lysine N-methyltransferase 2
CoREST complex
restin corepressor complex
SAH
S-adenosyl-l-homocysteine
l
SWI complex
ATP dependent chromatin remodeling complexes
Pan-Histone Demethylase Inhibitor
the inhibitor can simultaneously inhibit both LSDs and JHDMs
LSC colony
leukemic stem cell colony
Pan JmjC domain-containing demethylase inhibitor
the inhibitor can simultaneously inhibit all the members of JHDMs
E2F1
E2F transcription factor 1
E2F2
E2F transcription factor 2
RCC
renal cell carcinoma
Leukemic marrow infiltration reveals a novel role for Egr3 as a potent inhibitor of normal hematopoietic stem cell proliferation
期刊论文
2015, 卷号: 126, 期号: 11, 页码: 1302-1313
作者:
Cheng, Hui
;
Hao, Sha
;
Liu, Yanfeng
;
Pang, Yakun
;
Ma, Shihui
收藏
  |  
浏览/下载:2/0
  |  
提交时间:2020/01/13
N-Cadherin and Tie2 positive CD34(+) CD38(-)CD123(+) leukemic stem cell populations can develop acute myeloid leukemia more effectively in NOD/SCID mice
期刊论文
2014, 卷号: 38, 期号: 5, 页码: 632-637
作者:
Qiu, Shaowei
;
Jia, Yujiao
;
Xing, Haiyan
;
Yu, Tengteng
;
Yu, Jing
收藏
  |  
浏览/下载:6/0
  |  
提交时间:2020/01/13
Leukemic stem cell
N-Cadherin
Tie2
Acute myeloid leukemia
Hes1 mediates the different responses of hematopoietic stem and progenitor cells to T cell leukemic environment
期刊论文
2013, 卷号: 12, 期号: 2, 页码: 322-331
作者:
Tian, Chen
;
Zheng, Guoguang
;
Cao, Zhipan
;
Li, Qiao
;
Ju, Zhenyu
收藏
  |  
浏览/下载:3/0
  |  
提交时间:2020/01/13
hematopoietic stem cells
Hes1
cell cycle
leukemia
Distinct Effects of SCF and Hes1 On Normal Hematopoietic Stem and Progenitor Cells During Leukemic Cell Expansion in a T-ALL Mouse Model
期刊论文
2012, 卷号: 120, 期号: 21
作者:
Tian, Chen
;
Cao, Zhipan
;
Li, Qiao
;
Wang, Jinhong
;
Ju, Zhenyu
收藏
  |  
浏览/下载:6/0
  |  
提交时间:2020/01/13
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