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	Epigenetic targets and drug discovery Part 2: Histone demethylation and DNA methylation
	Liu, Ke; Liu, Yanli; Lau, Johnathan L; Min, Jinrong*
刊名	Pharmacology and Therapeutics
	2015
卷号	151页码:121-140
关键词	Histone demethylation DNA methylation Inhibitor Chemical probe Drug discovery LSD lysine-specific histone demethylase HDAC histone deacetylase REST REST corepressor DNMT DNA methyltransferase MAO monoamine oxidase AML acute myeloid leukemia KDM lysine-specific demethylase MLL mixed lineage leukemia FAD flavin adenine dinucleotide PCPA trans-2-phenylcyclopropylamine 2,4-PDCA 2, 4-pyridinedicarboxylic acid PHD plant homeobox domain SCLC small cell lung cancer JHDMs JmjC-domain-containing histone demethylases NOG N-oxalylglycine IOX1 5-carboxy-8-hydroxyquinoline MDS myelodysplastic syndrome 2-OG, 2-oxoglutarate or α-ketoglutarate G9a euchromatic histone-lysine N-methyltransferase 2 CoREST complex restin corepressor complex SAH S-adenosyl-l-homocysteine l SWI complex ATP dependent chromatin remodeling complexes Pan-Histone Demethylase Inhibitor the inhibitor can simultaneously inhibit both LSDs and JHDMs LSC colony leukemic stem cell colony Pan JmjC domain-containing demethylase inhibitor the inhibitor can simultaneously inhibit all the members of JHDMs E2F1 E2F transcription factor 1 E2F2 E2F transcription factor 2 RCC renal cell carcinoma
ISSN号	0163-7258
DOI	10.1016/j.pharmthera.2015.04.001
URL标识	查看原文
WOS记录号	WOS:000356546200011
内容类型	期刊论文
URI标识	http://www.corc.org.cn/handle/1471x/5151792
专题	华中师范大学
作者单位	1.[Liu, Ke 2.Liu, Yanli 3.Min, Jinrong] Cent China Normal Univ, Coll Life Sci, Hubei Key Lab Genet Regulat & Integrat Biol, Wuhan 430079, Peoples R China.
推荐引用方式 GB/T 7714	Liu, Ke,Liu, Yanli,Lau, Johnathan L,et al. Epigenetic targets and drug discovery Part 2: Histone demethylation and DNA methylation[J]. Pharmacology and Therapeutics,2015,151:121-140.
APA	Liu, Ke,Liu, Yanli,Lau, Johnathan L,&Min, Jinrong*.(2015).Epigenetic targets and drug discovery Part 2: Histone demethylation and DNA methylation.Pharmacology and Therapeutics,151,121-140.
MLA	Liu, Ke,et al."Epigenetic targets and drug discovery Part 2: Histone demethylation and DNA methylation".Pharmacology and Therapeutics 151(2015):121-140.

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