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浏览/检索结果: 共6条，第1-6条 帮助 已选(0)清除 条数/页：5101520253035404550556065707580859095100   排序方式：请选择作者升序作者降序题名升序题名降序发表日期升序发表日期降序提交时间升序提交时间降序 Design, synthesis and biological evaluation of LX2343 derivatives as neuroprotective agents for the treatment of Alzheimer's disease 期刊论文 EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2018, 卷号: 145, 页码: 622-633 作者:  Sun, Guanglong;  Wang, Junwei;  Guo, Xiaodan;  Lei, Min;  Zhang, Yinan 收藏  |  浏览/下载：27/0  |  提交时间：2019/01/08 LX2343 derivatives  Neuroprotective agents  Alzheimer's disease  Structural modifications  Structure-activity relationships   LX2343 alleviates cognitive impairments in AD model rats by inhibiting oxidative stress-induced neuronal apoptosis and tauopathy 期刊论文 ACTA PHARMACOLOGICA SINICA, 2017, 卷号: 38, 期号: 8, 页码: 1104-1119 作者:  Guo, Xiao-dan;  Sun, Guang-long;  Zhou, Ting-ting;  Wang, Yi-yang;  Xu, Xin 收藏  |  浏览/下载：36/0  |  提交时间：2019/01/08 Alzheimer's disease  LX2343  cognitive deficits  oxidative stress  tauopathy  mitochondria  GSK-3 beta inhibitor  neuroprotection  ICV-STZ rats   Small molecule lx2343 ameliorates cognitive deficits in ad model mice by targeting both amyloid beta production and clearance 期刊论文 Acta pharmacologica sinica, 2016, 卷号: 37, 期号: 10, 页码: 1281-1297 作者:  Guo, Xiao-dan;  Sun, Guang-long;  Zhou, Ting-ting;  Xu, Xin;  Zhu, Zhi-yuan 收藏  |  浏览/下载：37/0  |  提交时间：2019/05/09 Alzheimer's disease  N-(1,3-benzodioxol-5-yl)-2-[5-chloro-2-methoxy(phenylsulfonyl)anilino]acetamide (lx2343)  Streptozotocin  Amyloid beta  Pi3k  Autophagy  App/ps1 transgenic mice  Cognitive deficit  Bace1   Small molecule LX2343 ameliorates cognitive deficits in AD model mice by targeting both amyloid beta production and clearance 期刊论文 ACTA PHARMACOLOGICA SINICA, 2016, 卷号: 37, 期号: 10, 页码: 1281-1297 作者:  Guo, Xiao-dan;  Sun, Guang-long;  Zhou, Ting-ting;  Xu, Xin;  Zhu, Zhi-yuan 收藏  |  浏览/下载：14/0  |  提交时间：2019/01/08 Alzheimer's disease  N-(1,3-benzodioxol-5-yl)-2-[5-chloro-2-methoxy(phenylsulfonyl)anilino]acetamide (LX2343)  streptozotocin  amyloid beta  BACE1  PI3K  autophagy  APP/PS1 transgenic mice  cognitive deficit   smallmoleculelx2343amelioratescognitivedeficitsinadmodelmicebytargetingbothamyloidproductionandclearance 期刊论文 actapharmacologicasinica, 2016, 卷号: 000, 期号: 010, 页码: 1281 作者:  Guo Xiaodan;  Sun Guanglong;  Zhou Tingting;  Xu Xin;  Zhu Zhiyuan 收藏  |  浏览/下载：4/0  |  提交时间：2020/07/01 Alzheimer's disease  N-(1  3-benzodioxol-5-yl)-2-5-chloro-2-methoxy(phenylsulfonyl)anilinoacetamide (LX2343)  streptozotocin  amyloid β  BACE1  PI3K  autophagy  APP/PS1 transgenic mice  cognitive deficit   Small molecule LX2343 ameliorates cognitive deficits in AD model mice by targeting both amyloid β production and clearance 期刊论文 中国药理学报：英文版, 2016, 卷号: 000, 期号: 010, 页码: 1281 作者:  Guo Xiaodan;  Sun Guanglong;  Zhou Tingting;  Xu Xin;  Zhu Zhiyuan 收藏  |  浏览/下载：13/0  |  提交时间：2020/12/24 Alzheimer's disease  N-(1  3-benzodioxol-5-yl)-2-5-chloro-2-methoxy(phenylsulfonyl)anilinoacetamide (LX2343)  streptozotocin  amyloid β  BACE1  PI3K  autophagy  APP/PS1 transgenic mice  cognitive deficit