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Rational drug design of benzothiazole-based derivatives as potent signal transducer and activator of transcription 3 (STAT3) signaling pathway inhibitors
期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2021, 卷号: 216, 页码: 20
作者:
Gao, Dingding
;
Jin, Nan
;
Fu, Yixian
;
Zhu, Yueyue
;
Wang, Yujie
收藏
  |  
浏览/下载:43/0
  |  
提交时间:2021/06/11
STAT3 signaling pathway
Benzothiazole
Rational design
Antitumor activity
Molecular docking
SAF-248, a novel PI3K delta-selective inhibitor, potently suppresses the growth of diffuse large B-cell lymphoma
期刊论文
ACTA PHARMACOLOGICA SINICA, 2021, 页码: 11
作者:
Zhang, Xi
;
Duan, Yu-ting
;
Wang, Yi
;
Zhao, Xing-dong
;
Sun, Yi-ming
收藏
  |  
浏览/下载:36/0
  |  
提交时间:2021/05/24
PI3Kδ
PI3K
AKT
mTOR
diffuse large B-cell lymphoma
resistance
combination therapy
Janus Kinase Inhibitors: A Review of Their Application in the Vitiligo
期刊论文
MINI-REVIEWS IN MEDICINAL CHEMISTRY, 2021, 卷号: 21, 期号: 20, 页码: 3203-3218
作者:
Niu, C (Niu, Chao) [1] , [2] , [3] , [4]
;
Xie, HJ (Xie, Huijun) [1] , [2] , [3]
;
Aisa, HA (Aisa, Haji Akber) [1] , [2] , [3]
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  |  
浏览/下载:24/0
  |  
提交时间:2022/03/24
JAK-STAT
JAK inhibitors
dermatologic conditions
vitiligo
tofacitinib
ruxolitinib
Inhibition of Tumor Lymphangiogenesis is an Important Part that EGFR-TKIs Play in the Treatment of NSCLC
期刊论文
JOURNAL OF CANCER, 2020, 卷号: 11, 期号: 1, 页码: 241-250
作者:
Zhang, Yan
;
Yang, Xinying
;
Liu, Hongchun
;
Cai, Minghui
;
Yang Shentu
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  |  
浏览/下载:29/0
  |  
提交时间:2020/07/01
EGFR-TKIs
NSCLC
lymphangiogenesis
JAK/STAT3
LYVE-1
3-Deoxy-2 beta,16-dihydroxynagilactone E, a natural compound from Podocarpus nagi, preferentially inhibits JAK2/STAT3 signaling by allosterically interacting with the regulatory domain of JAK2 and induces apoptosis of cancer cells
期刊论文
ACTA PHARMACOLOGICA SINICA, 2019, 卷号: 40, 期号: 12, 页码: 1578-1586
作者:
Shan, Hui
;
Yao, Sheng
;
Ye, Yang
;
Yu, Qiang
收藏
  |  
浏览/下载:9/0
  |  
提交时间:2020/07/01
JAK/STAT
3-deoxy-2 beta,16-dihydroxynagilactone E
tyrosine kinase inhibitor
allosteric inhibitor
cancer
Tyrosine Kinase 2 (TYK2) Allosteric Inhibitors To Treat Autoimmune Diseases
期刊论文
JOURNAL OF MEDICINAL CHEMISTRY, 2019, 卷号: 62, 期号: 20, 页码: 8951-8952
作者:
Chang, Yu
;
Xu, Shilin
;
Ding, Ke
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  |  
浏览/下载:16/0
  |  
提交时间:2020/07/01
Novel-targeted therapy for hematological malignancies with JAK and HDAC dual inhibitors
期刊论文
FUTURE MEDICINAL CHEMISTRY, 2019, 卷号: 11, 期号: 15, 页码: 1849-1852
作者:
Liang, Xuewu
;
Liu, Hong
;
Zhang, Yingjie
收藏
  |  
浏览/下载:14/0
  |  
提交时间:2020/07/01
dual inhibitors
HDAC
hematological malignancies
JAK
multiple target drugs
Inhibition of phosphodiesterase-4 attenuates murine ulcerative colitis through interference with mucosal immunity
期刊论文
BRITISH JOURNAL OF PHARMACOLOGY, 2019, 卷号: 176, 期号: 13, 页码: 2209-2226
作者:
Li, Heng
;
Fan, Chen
;
Feng, Chunlan
;
Wu, Yanwei
;
Lu, Huimin
收藏
  |  
浏览/下载:20/0
  |  
提交时间:2020/07/01
Discovery of Novel Janus Kinase (JAK) and Histone Deacetylase (HDAC) Dual Inhibitors for the Treatment of Hematological Malignancies
期刊论文
JOURNAL OF MEDICINAL CHEMISTRY, 2019, 卷号: 62, 期号: 8, 页码: 3898-3923
作者:
Liang, Xuewu
;
Zang, Jie
;
Li, Xiaoyang
;
Tang, Shuai
;
Huang, Min
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  |  
浏览/下载:18/0
  |  
提交时间:2020/07/01
Signaling pathway inhibitors target breast cancer stem cells in triple-negative breast cancer
期刊论文
ONCOLOGY REPORTS, 2019, 卷号: 41, 期号: 1
作者:
Xu, Ning
;
Li, Wenlong
;
Yang, Hongmei
;
Li, Xiaoli
;
Han, Lou
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  |  
浏览/下载:25/0
  |  
提交时间:2019/12/05
TNBC
BCSCs
signaling pathway inhibitors
ALDH1
Notch
Hedgehog
JAK
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