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JC-010a, a novel selective SHP2 allosteric inhibitor, overcomes RTK/non-RTK-mediated drug resistance in multiple oncogene-addicted cancers
期刊论文
CANCER LETTERS, 2024, 卷号: 582, 页码: 15
作者:
Lu, Xuxiu
;
Yu, Rilei
;
Li, Zhen
;
Yang, Mengke
;
Dai, Jiajia
收藏
  |  
浏览/下载:2/0
  |  
提交时间:2024/04/07
Acquired resistance
Cancer
NSCLC
JC-010a
SHP2
Daqing formula ameliorated allergic asthma and airway dysbacteriosis in mice challenged with ovalbumin and ampicillin
期刊论文
JOURNAL OF ETHNOPHARMACOLOGY, 2024, 卷号: 318
作者:
Wu, Li-ren
;
Peng, Qian-Yu
;
Li, Xue-Jian
;
Guo, Mei-Ying
;
He, Jia-Qi
收藏
  |  
浏览/下载:10/0
  |  
提交时间:2023/11/10
Lung dysbiosis
Th1/Th2 balance
Antibiotic
GSK-3 ss
Discovery of Pyrrolo[2,3-d]pyrimidine derivatives as potent and selective colony stimulating factor 1 receptor kinase inhibitors
期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2022, 卷号: 243
作者:
Liang, Xiaofei
;
Wang, Chun
;
Wang, Beilei
;
Liu, Juan
;
Qi, Shuang
收藏
  |  
浏览/下载:27/0
  |  
提交时间:2022/12/23
CSF1R inhibitor
Kinase inhibitor
Macrophage polarization
The reversal of anti-HER2 resistance in advanced HER2-positive breast cancer using apatinib: two cases reports and literature review
期刊论文
TRANSLATIONAL CANCER RESEARCH, 2022
作者:
He, Libin
;
Shen, Xiabo
;
Liu, Yiyuan
;
Gao, Lu
;
Wu, Jiayi
收藏
  |  
浏览/下载:19/0
  |  
提交时间:2022/12/23
Advanced human epidermal growth factor receptor 2-positive breast cancer (advanced HER2-positive breast cancer)
apatinib
case report
S3I-201 derivative incorporating naphthoquinone unit as effective STAT3 inhibitors: Design, synthesis and anti-gastric cancer evaluation
期刊论文
BIOORGANIC & MEDICINAL CHEMISTRY, 2022, 卷号: 71
作者:
Li, Haobin
;
Cai, Maohua
;
Cao, Fei
;
Yu, Dehua
;
Yang, Jing
收藏
  |  
浏览/下载:14/0
  |  
提交时间:2022/12/22
STAT3 inhibitor
Quinone derivative
S3I-201
Anti -gastric cancer drug
Inhibition of STAT3 Signaling Pathway by Terphenyllin Suppresses Growth and Metastasis of Gastric Cancer
期刊论文
FRONTIERS IN PHARMACOLOGY, 2022, 卷号: 13
作者:
Yu, Dehua
;
Qi, Simin
;
Guan, Xiaoqing
;
Yu, Wenkai
;
Yu, Xuefei
收藏
  |  
浏览/下载:13/0
  |  
提交时间:2022/12/23
STAT3
inhibitor
natural product
gastric cancer
terphenyllin
Synthesis of Abscisic Acid in Neopyropia yezoensis and Its Regulation of Antioxidase Genes Expressions Under Hypersaline Stress
期刊论文
FRONTIERS IN MICROBIOLOGY, 2022, 卷号: 12, 页码: 15
作者:
Yang, Jiali
;
Gu, Wenhui
;
Feng, Zezhong
;
Yu, Bin
;
Niu, Jianfeng
收藏
  |  
浏览/下载:17/0
  |  
提交时间:2022/04/12
abscisic acid
antioxidase
ABRE motif
ABA signaling pathway
Neopyropia yezoensis
Synthesis and biological evaluation of 2,5-diaryl-1,3,4-oxadiazole derivatives as novel Src homology 2 domain-containing protein tyrosine phosphatase 2 (SHP2) inhibitors
期刊论文
BIOORGANIC CHEMISTRY, 2021, 卷号: 116, 页码: 13
作者:
Meng, Xiang-Dong
;
Gao, Li-Xin
;
Wang, Zhi-Jia
;
Feng, Bo
;
Zhang, Chun
收藏
  |  
浏览/下载:30/0
  |  
提交时间:2021/12/01
2,5-diphenyl-1,3,4-oxadiazole derivatives
SHP2
Inhibitors
Structure-activity relationships (SAR)
Discovery of a potent, selective, and covalent ZAP-70 kinase inhibitor
期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2021, 卷号: 219, 页码: 12
作者:
Rao, Danni
;
Li, Heng
;
Ren, Xuelian
;
Sun, Yaoliang
;
Wen, Cuiyun
收藏
  |  
浏览/下载:27/0
  |  
提交时间:2021/08/17
Zeta-chain associated protein kinase 70 kDa (ZAP-70)
Covalent inhibitor
T cell
Autoimmune diseases
Imbalance of TGF-beta 1/BMP-7 pathways induced by M2-polarized macrophages promotes hepatocellular carcinoma aggressiveness
期刊论文
MOLECULAR THERAPY, 2021, 卷号: 29, 期号: 6, 页码: 2067-2087
作者:
Ning, Junya
;
Ye, Yingnan
;
Bu, Dechao
;
Zhao, Gang
;
Song, Tianqiang
收藏
  |  
浏览/下载:34/0
  |  
提交时间:2021/12/01
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