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上海药物研究所 [13]
新疆理化技术研究所 [2]
大连化学物理研究所 [2]
湖南中医药大学 [2]
长春应用化学研究所 [2]
厦门大学 [1]
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期刊论文 [39]
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A New Harziane Diterpene, Harziaketal A, and a New Sterol, Trichosterol A, from the Marine-Alga-Epiphytic
Trichoderma
sp. Z43
期刊论文
CHEMISTRY & BIODIVERSITY, 2023, 页码: 5
作者:
Shi, Zhen-Zhen
;
Yin, Xiu-Li
;
Song, Yin-Ping
;
Ji, Nai-Yun
收藏
  |  
浏览/下载:6/0
  |  
提交时间:2023/11/15
antimicroalgal activity
harziane diterpene
steroid
structure elucidation
Trichoderma
Synthesis and Biological Activities of Dihydrooxazolo[5,4-d]- pyrrolo[1,2-a]pyrimidinones
期刊论文
CHINESE JOURNAL OF ORGANIC CHEMISTRY, 2022, 卷号: 42, 期号: 2, 页码: 543-556
作者:
Zeng, Y (Zeng Yan) [1] , [2]
;
Nie, LF (Nie Lifei) [1]
;
Niu, C (Niu Chao) [1]
;
Mamatjan, A (Mamatjan Aytilla) [1] , [2]
;
Bozorov, K (Bozorov Khurshed) [1]
收藏
  |  
浏览/下载:23/0
  |  
提交时间:2022/05/17
oxazopyrimidinone
synthesis
bioisosterism
anticancer activity
antimicrobial activity
structure-activity relationships (SARs)
IC50: an unsuitable measure for large-sized prostate cancer spheroids in drug sensitivity evaluation
期刊论文
BOSNIAN JOURNAL OF BASIC MEDICAL SCIENCES, 2022, 卷号: 22
作者:
Xu, Yipeng
;
Pachnikova, Gabriela
;
Wang, He
;
Wu, Yaoyao
;
Przybilla, Dorothea
收藏
  |  
浏览/下载:10/0
  |  
提交时间:2022/12/23
IC50
docetaxel
spheroids
drug testing
preclinical models
prostate cancer
2D clinical models
3D clinical models
cell culture
Discovery of novel USP8 inhibitors via Ubiquitin-Rho-110 fluorometric assay based high throughput screening
期刊论文
BIOORGANIC CHEMISTRY, 2020, 卷号: 101, 页码: 9
作者:
Han, Jie
;
Tian, Yucheng
;
Yu, Liang
;
Zhang, Qilin
;
Xu, Xi
收藏
  |  
浏览/下载:61/0
  |  
提交时间:2020/12/24
Ubiquitination
High throughput screening
Drug discovery
USP8
Proteomic Comparison of the Cytotoxicology of Two Diastereomers of Citreamicin Reveals Differentially Activation of NF-kappa B Pathway
期刊论文
FRONTIERS IN MARINE SCIENCE, 2020, 卷号: 7, 页码: 12
作者:
Liu, Ling-Li
;
Sun, Jin
;
Xu, Ying
;
He, Li-Sheng
;
Kondethimmanahalli, Chandramouli
收藏
  |  
浏览/下载:8/0
  |  
提交时间:2020/06/16
proteomic
citreamicin
toxicology
antitumor antibiotic
iTRAQ
Discovery of Highly Potent, Selective, and Orally Efficacious p300/CBP Histone Acetyltransferases Inhibitors
期刊论文
JOURNAL OF MEDICINAL CHEMISTRY, 2020, 卷号: 63, 期号: 3, 页码: 1337-1360
作者:
Yang, Yaxi
;
Zhang, Rukang
;
Li, Zhaojun
;
Mei, Lianghe
;
Wan, Shili
收藏
  |  
浏览/下载:40/0
  |  
提交时间:2020/07/01
Novel dihydroartemisinin dimer containing nitrogen atoms inhibits growth of endometrial cancer cells and may correlate with increasing intracellular peroxynitrite
期刊论文
SCIENTIFIC REPORTS, 2019, 卷号: 9, 页码: 14
作者:
Zhu, Yan
;
Klausen, Christian
;
Zhou, Jieyun
;
Guo, Xiangjie
;
Zhang, Yu
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  |  
浏览/下载:81/0
  |  
提交时间:2020/07/01
In silico screening of a novel scaffold for fructose-1,6-bisphosatase (FBPase) inhibitors
期刊论文
Journal of Molecular Graphics and Modelling, 2019, 卷号: 86, 页码: 142-148
作者:
Huang, Yunyuan
;
Chi, Bo
;
Xu, Yanhong
;
Song, Rongrong
;
Wei, Lin
收藏
  |  
浏览/下载:32/0
  |  
提交时间:2019/12/23
Fructose-1,6-bisphosphate (FBPase)
FBPase inhibitors
DOX2.0
FBPase
fructose-1,6-bisphosphatase
FBP
fructose-1,6-biphosphate
IC50
half maximal inhibitory concentration
PAINS
Pan Assay Interference
T2D
Type 2 diabetes
SAR
structure−activity relationship
EGP
endogenous glucose production
GNG
gluconeogenesis
AMP
adenosine monophosphate
DOX
Docking ONIOM eXtended ONIOM (XO)
DOX2.0
Docking PM7@Mopac XO2
LE
ligand efficiency
LELP
lipophilicity-corrected ligand efficiency
Disulfiram Copper Nanoparticles Prepared with a Stabilized Metal Ion Ligand Complex Method for Treating Drug-Resistant Prostate Cancers
期刊论文
ACS APPLIED MATERIALS & INTERFACES, 2018, 卷号: 10, 期号: 48, 页码: 41118-41128
作者:
Chen, Wu
;
Yang, Wen
;
Chen, Pengyu
;
Huang, Yongzhuo
;
Li, Feng
收藏
  |  
浏览/下载:96/0
  |  
提交时间:2019/01/08
disulfiram
copper diethyldithiocarbamate
drug resistance
prostate cancer
nanoparticle
drug delivery
paraptosis
Discovery of 1,8-acridinedione derivatives as novel GCN5 inhibitors via high throughput screening
期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2018, 卷号: 151, 页码: 740-751
作者:
Xiong, Huan
;
Han, Jie
;
Wang, Jun
;
Lu, Wenchao
;
Wang, Chen
收藏
  |  
浏览/下载:28/0
  |  
提交时间:2019/01/08
Epigenetics
Histone acetyltransferase
GCN5
High throughput screening
1,8-Acridinedione derivative
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