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山东大学 [18]
西北高原生物研究所 [9]
上海药物研究所 [2]
新疆理化技术研究所 [2]
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期刊论文 [42]
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A Phase I Study to Evaluate the Safety, Tolerability, and Pharmacokinetics of TPN171H, a Novel Phosphodiesterase Type 5 Inhibitor, in Healthy Subjects
期刊论文
DRUG DESIGN DEVELOPMENT AND THERAPY, 2021, 卷号: 15, 页码: 2947-2959
作者:
Qian, Hongjie
;
Chen, Qian
;
Lang, Liyu
;
Zou, Yang
;
Pu, Huahua
收藏
  |  
浏览/下载:35/0
  |  
提交时间:2021/08/17
TPN171H
PDE5 inhibitor
safety
pharmacokinetics
food effect
healthy subjects
Investigation of Losartan Potassium as an eco-friendly corrosion inhibitor for copper in 0.5 M H2SO4
期刊论文
JOURNAL OF MOLECULAR LIQUIDS, 2020, 卷号: 305
作者:
Li, Hao
;
Zhang, Shengtao
;
Tan, Bochuan
;
Qiang, Yujie
;
Li, Wenpo
收藏
  |  
浏览/下载:22/0
  |  
提交时间:2020/12/16
MILD-STEEL CORROSION
SULFURIC-ACID
MOLECULAR-DYNAMICS
CARBON-STEEL
IONIC LIQUIDS
ANTICORROSIVE MECHANISM
STAINLESS-STEEL
CU CORROSION
HCL SOLUTION
EXTRACT
Triterpenoids from the genus Gynostemma: Chemistry and pharmacological activities
期刊论文
Journal of Ethnopharmacology, 2020, 卷号: -, 期号: -, 页码: -
作者:
Author links open overlay panelHieuNguyen-Ngoc
;
Thi KimQuy Ha
;
Yang JL(杨军丽)
;
Ha ThanhTung Pham
;
Won KeunOh
收藏
  |  
浏览/下载:21/0
  |  
提交时间:2020/11/16
Gynostemma
phytochemistry
pharmacology
traditional usage
saponin
triterpenoid
Pharmacokinetics-Driven Optimization of 4(3H)-Pyrimidinones as Phosphodiesterase Type 5 Inhibitors Leading to TPN171, a Clinical Candidate for the Treatment of Pulmonary Arterial Hypertension
期刊论文
JOURNAL OF MEDICINAL CHEMISTRY, 2019, 卷号: 62, 期号: 10, 页码: 4979-4990
作者:
Wang, Zhen
;
Jiang, Xiangrui
;
Zhang, Xianglei
;
Tian, Guanghui
;
Yang, Rulei
收藏
  |  
浏览/下载:39/0
  |  
提交时间:2020/07/01
Pharmacokinetics-Driven Optimization of 4(3H)-Pyrimidinones as Phosphodiesterase Type 5 Inhibitors Leading to TPN171, a Clinical Candidate for the Treatment of Pulmonary Arterial Hypertension
期刊论文
JOURNAL OF MEDICINAL CHEMISTRY, 2019, 卷号: 62, 期号: 10, 页码: 4979-4990
作者:
Wang, Z (Wang, Zhen)[ 1 ]
;
Jiang, XR (Jiang, Xiangrui)[ 1 ]
;
Zhang, XL (Zhang, Xianglei)[ 1,2 ]
;
Tian, GH (Tian, Guanghui)[ 3 ]
;
Yang, RL (Yang, Rulei)[ 3 ]
收藏
  |  
浏览/下载:137/0
  |  
提交时间:2019/06/28
Association between household physical activity level and type 2 diabetes among urban males in northern China
期刊论文
PUBLIC HEALTH, 2018, 卷号: 163, 页码: 113-120
作者:
Yang, J.
;
Zhang, Y. L.
;
Ye, J.
;
Guo, Q.
;
Sun, Y. N.
收藏
  |  
浏览/下载:20/0
  |  
提交时间:2019/12/25
Housework
Type 2 diabetes
Odds ratio
Men
China
Study on the clinical efficacy of specific phosphodiesterase inhibitor in patients with pulmonary hypertension due to left heart disease
期刊论文
EXPERIMENTAL AND THERAPEUTIC MEDICINE, 2018, 卷号: 16, 期号: 2, 页码: 1175-1186
作者:
Han, Bing
;
Wang, Qingli
收藏
  |  
浏览/下载:7/0
  |  
提交时间:2019/12/11
specific phosphodiesterase inhibitor
pulmonary hypertension due to left
heart disease
left atrial diameter
left ventricular end-diastolic
diameter
left ventricular ejection fraction
pulmonary artery systolic
pressure
tricuspid annular plane systolic excursion
right ventricular
fractional area change
N-terminal pro-B-type natriuretic peptide
hypersensitive C-reactive protein
Candesartan targeting of angiotensin II type I receptor demonstrates benefits for hypertension in pregnancy via the NF-kappa B signaling pathway
期刊论文
MOLECULAR MEDICINE REPORTS, 2018, 卷号: 18, 期号: 1, 页码: 705-714
作者:
Zhao, Xudong
;
Wang, Xietong
收藏
  |  
浏览/下载:3/0
  |  
提交时间:2019/12/11
Candesartan
gestational hypertension
angiotensin
nuclear factor-kappa
B
Hypaphorine, an Indole Alkaloid Isolated from Caragana korshinskii Kom., Inhibites 3T3-L1 Adipocyte Differentiation and Improves Insulin Sensitivity in Vitro
期刊论文
CHEMISTRY & BIODIVERSITY, 2017
Luan, Guangxiang
;
Tie, Fangfang
;
Yuan, Zhenzhen
;
Li, Gang
;
He, Jie
;
Wang, Zhenhua
;
Wang, Honglun
收藏
  |  
浏览/下载:19/0
  |  
提交时间:2019/06/14
Hypaphorine, an Indole Alkaloid Isolated from Caragana korshinskii Kom., Inhibites 3T3-L1 Adipocyte Differentiation and Improves Insulin Sensitivity in Vitro
期刊论文
CHEMISTRY & BIODIVERSITY, 2017
Luan, Guangxiang
;
Tie, Fangfang
;
Yuan, Zhenzhen
;
Li, Gang
;
He, Jie
;
Wang, Zhenhua
;
Wang, Honglun
收藏
  |  
浏览/下载:14/0
  |  
提交时间:2019/07/05
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