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上海药物研究所 [15]
大连理工大学 [3]
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中国科学院大学 [1]
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期刊论文 [22]
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Combating liver cancer through GO-targeted biomaterials
期刊论文
BIOMEDICAL MATERIALS, 2021, 卷号: 16, 期号: 6, 页码: 14
作者:
Huang, Xing
;
Zhang, Jiaxin
;
Song, Yijie
;
Zhang, Tong
;
Wang, Bing
收藏
  |  
浏览/下载:62/0
  |  
提交时间:2021/11/04
graphene oxide
hydroxycamptothecin
anti-cancer
drug delivery system
targeting
Nitidine chloride exerts anti-inflammatory action by targeting Topoisomerase I and enhancing IL-10 production
期刊论文
2019, 卷号: 148, 页码: 104368
作者:
Yang Niao
;
Yue Rongcai
;
Ma Jinzhu
;
Li Wencai
;
Zhao Zeng
收藏
  |  
浏览/下载:39/0
  |  
提交时间:2020/01/03
Chelerythrine Chloride (PubChem CID: 72311)
DNA topoisomerase I inhibitor
Endotoxemia
Interleukin-10
Irinotecan hydrochloride (PubChem CID: 74990)
LY294002 (PubChem CID: 3973)
Lipopolysaccharide
MK-2206 (PubChem CID: 46930998)
Nitidine Chloride (PubChem CID: 25659)
Phosphatidylinositol 3-kinase/Akt pathway
SN-38 (PubChem CID: 104842)
Sanguinarine chloride (PubChem CID: 68635)
Topotecan hydrochloride (PubChem CID: 60699)
New tanshinone I derivatives S222 and S439 similarly inhibit topoisomerase I/II but reveal different p53-dependency in inducing G2/M arrest and apoptosis
期刊论文
BIOCHEMICAL PHARMACOLOGY, 2018, 卷号: 154, 页码: 255-264
作者:
Tian, Qian-Ting
;
Ding, Chun-Yong
;
Song, Shan-Shan
;
Wang, Ying-Qing
;
Zhang, Ao
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  |  
浏览/下载:40/0
  |  
提交时间:2019/01/08
Tanshinone-1
S222
S439
Anticancer targets
DNA topoisomerases
P53
Design and synthesis of 2-phenylnaphthalenoids and 2-phenylbenzofuranoids as DNA topoisomerase inhibitors and antitumor agents
期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2015, 卷号: 102, 页码: 277-287
作者:
Hao, Huilin
;
Chen, Wang
;
Zhu, Jing
;
Lu, Chunhua
;
Shen, Yuemao
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  |  
浏览/下载:2/0
  |  
提交时间:2019/12/17
2-Phenylnaphthalenoids
2-Phenylbenzofuranoids
Topoisomerase II alpha
inhibitor
Antitumor
Synthesis of 7-Triazole-substituted Camptothecin via Click Chemistry and Evaluation of in vitro Antitumor Activity
期刊论文
CHINESE JOURNAL OF CHEMISTRY, 2014, 卷号: 32, 期号: 2, 页码: 157-162
作者:
Wang, Lei
;
Yuan, Wei
;
Zhang, Jie
;
Tong, Linjiang
;
Luo, Yu
收藏
  |  
浏览/下载:7/0
  |  
提交时间:2019/01/08
camptothecin
7-triazole-substituted camptothecin
click chemistry
antitumor
Microscopic modes and free energies for topoisomerase I-DNA covalent complex binding with non-camptothecin inhibitors by molecular docking and dynamics simulations
期刊论文
THEORETICAL CHEMISTRY ACCOUNTS, 2013, 卷号: 132, 页码: -
作者:
Wei, Ning-Ning
;
Hamza, Adel
;
Hao, Ce
;
Xiu, Zhilong
;
Zhan, Chang-Guo
收藏
  |  
浏览/下载:3/0
  |  
提交时间:2019/12/11
Protein-ligand interaction
Binding affinity
Molecular dynamics simulation
Enzyme inhibitor
Synthesis and antitumor activity of 10-arylcamptothecin derivatives
期刊论文
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2011, 卷号: 21, 期号: 7, 页码: 2071-2074
作者:
Jiao, Yu
;
Liu, Hongchun
;
Geng, Meiyu
;
Duan, Wenhu
收藏
  |  
浏览/下载:8/0
  |  
提交时间:2019/01/08
Antitumor activity
Camptothecin derivative
Lactone stability
Synthesis
Topoisomerase I inhibitor
A Series of alpha-Heterocyclic Carboxaldehyde Thiosemicarbazones Inhibit Topoisomerase II alpha Catalytic Activity
期刊论文
JOURNAL OF MEDICINAL CHEMISTRY, 2010, 卷号: 53, 期号: 8, 页码: 3048-3064
作者:
Huang, He
;
Chen, Qin
;
Ku, Xin
;
Meng, Linghua
;
Lin, Liping
收藏
  |  
浏览/下载:17/0
  |  
提交时间:2019/01/08
Pharmacokinetics, tissue distribution, and metabolism of novel DNA topoisomerase I inhibitor yuanhuacine in rabbit
期刊论文
XENOBIOTICA, 2009, 卷号: 39, 页码: 273-281
作者:
Zhang, S. X.
;
Yang, P. W.
;
Zhang, D. C.
;
Dong, W. Q.
;
Zhang, F. H.
收藏
  |  
浏览/下载:7/0
  |  
提交时间:2019/12/24
Yuanhuacine
pharmacokinetics
metabolism
DNA topoisomerase I inhibitor
anti-cancer agent
Evaluation of poly(D,L-lactide-co-glycolide) microspheres for the lung-targeting of yuanhuacine, a novel DNA topoisomerase I inhibitor
期刊论文
JOURNAL OF DRUG TARGETING, 2009, 卷号: 17, 页码: 286-293
作者:
Zhang, Shixuan
;
Gao, Xiujuan
;
Shen, Kaihua
;
Yang, Puwen
;
Ju, Xiulan
收藏
  |  
浏览/下载:3/0
  |  
提交时间:2019/12/24
PLGA microspheres
lung targeting
yuanhuacine
fluorescent spiropyran labeled
anticancer
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