Combating liver cancer through GO-targeted biomaterials

doi:10.1088/1748-605X/ac1f72

	Combating liver cancer through GO-targeted biomaterials
	Huang, Xing 1,2; Zhang, Jiaxin 2; Song, Yijie 2; Zhang, Tong 1,2; Wang, Bing 3
刊名	BIOMEDICAL MATERIALS
	2021-11-01
卷号	16 期号:6 页码:14
关键词	graphene oxide hydroxycamptothecin anti-cancer drug delivery system targeting
ISSN号	1748-6041
DOI	10.1088/1748-605X/ac1f72
通讯作者	Zhang, Tong(zhangtdmj@hotmail.com) ; Wang, Bing(bwang@simm.ac.cn)
英文摘要	Hydroxycamptothecin (HCPT) is a topoisomerase I inhibitor, and it has been widely used clinically in the treatment of primary liver cancer, gastric cancer, and other tumors. The clinical application of HCPT is limited by its water solubility, and it has certain toxicity to patients with tumor. Therefore, the effective tumor site accumulation of HCPT is necessary. This work studied the inhibitory effect of HCPT on the proliferation and migration of human liver cancer cells (HepG-2) and used carboxymethyl chitosan (CMC) and hyaluronic acid (HA) to modify graphene oxide (GO) as nano-carrier materials, which load HCPT to achieve a drug delivery system for liver tumors with good biocompatibility and high drug loading. HCPT can significantly inhibit proliferation and migration of HepG-2, enhance the release of reactive oxygen species, reduce mitochondrial membrane potential, and induce apoptosis. The GO-CMC-HA/HCPT drug delivery system enabled HepG-2 to uptake more HCPT, thereby inhibiting its proliferation and improving the efficacy of HCPT in vivo and in vitro. This study explored a potential therapy strategy by preparing a GO-based tumor-targeted drug delivery system.
资助项目	Program of Shanghai Academic/Technology Research Leader[18XD1403700] ; National Science and Technology Major Project[2019ZX09201004-002] ; Key project of Shanghai 3 year plan[ZY (2018-2020)-CCCX-2001-04]
WOS关键词	DRUG-DELIVERY ; NANOPARTICLES ; 10-HYDROXYCAMPTOTHECIN ; GRAPHENE ; CAMPTOTHECIN ; LIPOSOMES ; APOPTOSIS ; OXIDE ; DNA
WOS研究方向	Engineering ; Materials Science
语种	英语
出版者	IOP PUBLISHING LTD
WOS记录号	WOS:000692877500001
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/297586]
专题	中国科学院上海药物研究所
通讯作者	Zhang, Tong; Wang, Bing
作者单位	1.Shanghai Univ Tradit Chinese Med, Expt Ctr Teaching & Learning, Shanghai, Peoples R China 2.Shanghai Univ Tradit Chinese Med, Sch Pharm, Shanghai, Peoples R China 3.Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai, Peoples R China
推荐引用方式 GB/T 7714	Huang, Xing,Zhang, Jiaxin,Song, Yijie,et al. Combating liver cancer through GO-targeted biomaterials[J]. BIOMEDICAL MATERIALS,2021,16(6):14.
APA	Huang, Xing,Zhang, Jiaxin,Song, Yijie,Zhang, Tong,&Wang, Bing.(2021).Combating liver cancer through GO-targeted biomaterials.BIOMEDICAL MATERIALS,16(6),14.
MLA	Huang, Xing,et al."Combating liver cancer through GO-targeted biomaterials".BIOMEDICAL MATERIALS 16.6(2021):14.