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科研机构
上海药物研究所 [15]
湖南大学 [6]
复旦大学上海医学院 [3]
金属研究所 [2]
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期刊论文 [43]
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Histone methyltransferase SET8 is regulated by miR-192/215 and induces oncogene-induced senescence via p53-dependent DNA damage in human gastric carcinoma cells
期刊论文
CELL DEATH & DISEASE, 2020, 卷号: 11, 期号: 10, 页码: 15
作者:
Zhang, Xiaojing
;
Peng, Yin
;
Yuan, Yuan
;
Gao, Yuli
;
Hu, Fan
收藏
  |  
浏览/下载:50/0
  |  
提交时间:2021/12/01
Targeting epigenetic machinery: Emerging novel allosteric inhibitors
期刊论文
PHARMACOLOGY & THERAPEUTICS, 2019, 卷号: 204, 页码: 24
作者:
Ye, Fei
;
Huang, Jing
;
Wang, Hongbo
;
Luo, Cheng
;
Zhao, Kehao
收藏
  |  
浏览/下载:20/0
  |  
提交时间:2020/07/01
Epigenetics
PRC2
MLL complex
SWI/SNF
DNMT1
allosteric inhibitors
Computational Study of Novel Natural Inhibitors Targeting O-6-Methylguanine-DNA Methyltransferase
期刊论文
WORLD NEUROSURGERY, 2019, 卷号: 130
作者:
Jiang, Shanshan
;
Yang, Liu
;
Li, Weihang
;
Zhao, Yingjing
;
Cheng, Ye
收藏
  |  
浏览/下载:19/0
  |  
提交时间:2019/12/05
Discovery Studio
Inhibitor
O-6-Benzylguanine (O-6-BG)
O-6-methylguanine-DNA methyltransferase (MGMT)
Virtual screening
Discovery of potent DOT1L inhibitors by AlphaLISA based High Throughput Screening assay
期刊论文
BIOORGANIC & MEDICINAL CHEMISTRY, 2018, 卷号: 26, 期号: 8, 页码: 1751-1758
作者:
Song, Yakai
;
Li, Linjuan
;
Chen, Yantao
;
Liu, Jingqiu
;
Xiao, Senhao
收藏
  |  
浏览/下载:42/0
  |  
提交时间:2019/01/08
DOT1L
MLL-rearranged leukemia
AlphaLISA
HTS
Novel inhibitors
Biochemical Studies and Molecular Dynamic Simulations Reveal the Molecular Basis of Conformational Changes in DNA Methyltransferase-1
期刊论文
ACS CHEMICAL BIOLOGY, 2018, 卷号: 13, 期号: 3, 页码: 772-781
作者:
Ye, Fei
;
Kong, Xiangqian
;
Zhang, Hao
;
Liu, Yan
;
Shao, Zhiyuan
收藏
  |  
浏览/下载:35/0
  |  
提交时间:2019/01/08
The pivotal role of DNA methylation in the radio-sensitivity of tumor radiotherapy
期刊论文
CANCER MEDICINE, 2018, 卷号: 7, 期号: 8
作者:
Fu, Xiaolong
;
Zhu, Xueru
;
Tan, Li
;
Wang, Yiting
收藏
  |  
浏览/下载:3/0
  |  
提交时间:2019/12/05
DNA methylation
DNA methyltransferase inhibitors
radio-resistant
radio-sensitivity
A simple and universal electrochemical assay for sensitive detection of DNA methylation, methyltransferase activity and screening of inhibitors
期刊论文
2018, 卷号: 814, 页码: 144-152
作者:
Bao, Jing[1]
;
Geng, Xintong[1]
;
Hou, Changjun[1]
;
Zhao, Yanan[1]
;
Huo, Danqun[2]
收藏
  |  
浏览/下载:11/0
  |  
提交时间:2019/11/28
A simple and universal electrochemical assay for sensitive detection of DNA methylation, methyltransferase activity and screening of inhibitors
期刊论文
Journal of Electroanalytical Chemistry, 2018, 卷号: Vol.814, 页码: 144-152
作者:
Jing Bao
;
Xintong Geng
;
Changjun Hou
;
Yanan Zhao
;
Danqun Huo
收藏
  |  
浏览/下载:13/0
  |  
提交时间:2019/02/28
Electrochemical biosensor
DNA methylation
Methyltransferase
Inhibitors
In Silico Prediction of O-6-Methylguanine-DNA Methyltransferase Inhibitory Potency of Base Analogs with QSAR and Machine Learning Methods
期刊论文
2018, 卷号: 23, 期号: 11
作者:
Sun, Guohui
;
Fan, Tengjiao
;
Sun, Xiaodong
;
Hao, Yuxing
;
Cui, Xin
收藏
  |  
浏览/下载:7/0
  |  
提交时间:2020/01/03
MGMT
anticancer alkylating agents
resistance
inhibitors
QSAR
classification
A DNA as a Substrate and an Enzyme: Direct Profiling of Methyltransferase Activity by Cytosine Methylation of a DNAzyme
期刊论文
Chemistry - A European Journal, 2018, 卷号: 24, 期号: 54, 页码: 14500-14505
作者:
Li, Wang
;
Chen, Siyi
;
Xu, Dong
;
Wen, Qian
;
Yang, Tao*
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  |  
浏览/下载:3/0
  |  
提交时间:2019/12/28
aptamers
biosensors
cancer
DNAzymes
inhibitors
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