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上海药物研究所 [8]
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期刊论文 [18]
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Discovery and Development of a Potent, Selective, and Orally Bioavailable CHK1 Inhibitor Candidate: 5-((4-((3-Amino-3-methylbutyl)amino)-5-(trifluoromethyl)pyrimidin-2-yl)amino)picolinonitrile
期刊论文
JOURNAL OF MEDICINAL CHEMISTRY, 2021, 卷号: 64, 期号: 20, 页码: 15069-15090
作者:
Jin, Tingting
;
Xu, Lei
;
Wang, Peipei
;
Hu, Xiaobei
;
Zhang, Runyuan
收藏
  |  
浏览/下载:23/0
  |  
提交时间:2022/01/04
Design, Synthesis, and Biological Evaluation of Orally Bioavailable CHK1 Inhibitors Active against Acute Myeloid Leukemia
期刊论文
CHEMMEDCHEM, 2021, 页码: 12
作者:
Jin, Tingting
;
Wang, Peipei
;
Long, Xiubing
;
Jiang, Kailong
;
Song, Pinrao
收藏
  |  
浏览/下载:133/0
  |  
提交时间:2021/05/24
CHK1 inhibitor
diaminopyrimidine
DNA damage response
oral bioavailability
Downregulation of CDC20 Increases Radiosensitivity through Mcl-1/p-Chk1-Mediated DNA Damage and Apoptosis in Tumor Cells
期刊论文
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2020, 卷号: 21
作者:
Gao, Yang
;
Wen, Pengbo
;
Chen, Bin
;
Hu, Guanshuo
;
Wu, Lijun
收藏
  |  
浏览/下载:49/0
  |  
提交时间:2020/11/30
CDC20
radiotherapy
Mcl-1
p-Chk1
mitochondrial-dependent apoptotic pathway
Harnessing the targeting potential of differential radiobiological effects of photon versus particle radiation for cancer treatment
期刊论文
JOURNAL OF CELLULAR PHYSIOLOGY, 2020, 页码: 17
作者:
Zhang, Jinhua
;
Si, Jing
;
Gan, Lu
;
Zhou, Rong
;
Guo, Menghuan
收藏
  |  
浏览/下载:25/0
  |  
提交时间:2022/01/12
DNA damage
DNA repair
particle therapy
photon therapy
radiosensitizer
Discovery of (R)-5-((5-(1-methyl-1H-pyrazol-4-yl)-4-(methylamino) pyrimidin-2-yl)amino)-3-(piperidin-3-yloxy)picolinonitrile, a novel CHK1 inhibitor for hematologic malignancies
期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2019, 卷号: 173, 页码: 44-62
作者:
Tong, Lexian
;
Song, Pinrao
;
Jiang, Kailong
;
Xu, Lei
;
Jin, Tingting
收藏
  |  
浏览/下载:19/0
  |  
提交时间:2020/07/01
CHK1 kinase inhibitor
Selectivity
Monotherapy
Hematologic malignancies
Acetyl-macrocalin B suppresses tumor growth in esophageal squamous cell carcinoma and exhibits synergistic anti-cancer effects with the Chk1/2 inhibitor AZD7762
期刊论文
TOXICOLOGY AND APPLIED PHARMACOLOGY, 2019, 卷号: 365, 页码: 71-83
作者:
Wang, Jing-Nan
;
Che, Yun
;
Yuan, Zu-Yang
;
Lu, Zhi-Liang
;
Li, Yuan
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  |  
浏览/下载:76/0
  |  
提交时间:2019/03/18
Acetyl-macrocalin B
Reactive oxygen species
p38 MAPK
Chk1/Chk2
Esophageal squamous cell carcinoma
Pharmacophore modeling, molecular docking and molecular dynamics simulations toward identifying lead compounds for Chk1
期刊论文
COMPUTATIONAL BIOLOGY AND CHEMISTRY, 2018, 卷号: 76, 页码: 53-60
作者:
Li, Yaping
;
Peng, Jiale
;
Zhou, Yeheng
;
Li, Penghua
;
Li, Yingying
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  |  
浏览/下载:29/0
  |  
提交时间:2018/11/12
Checkpoint kinase 1 inhibitor
Virtual screening
Pharmacophore modeling
Molecular docking
Molecular dynamics simulations
Pharmacophore modeling, molecular docking and molecular dynamics simulations toward identifying lead compounds for Chk1
期刊论文
Computational Biology and Chemistry, 2018
作者:
Yaping Li
;
Jiale Peng
;
Yeheng Zhou
;
Penghua Li
;
Yingying Li
收藏
  |  
浏览/下载:3/0
  |  
提交时间:2019/02/28
Checkpoint
kinase
1
inhibitor
virtual
screening
pharmacophore
modeling
molecular
docking
molecular
dynamics
simulations
RNF126 as a biomarker of a poor prognosis in invasive breast cancer and CHK1 inhibitor efficacy in breast cancer cells
期刊论文
Clinical Cancer Research, 2018, 卷号: 24, 期号: 7, 页码: 1629-1643
作者:
Shanhuai Ma
;
Pengyan Fa
;
Zhefu Ma
;
Hongbing Wang
;
Yao Zhang
收藏
  |  
浏览/下载:35/0
  |  
提交时间:2018/09/28
Rnf126
Chk1
Replication Stress
Breast Cancer
Target Therapy
The Chk1 inhibitor MK-8776 increases the radiosensitivity of human triple-negative breast cancer by inhibiting autophagy
期刊论文
ACTA PHARMACOLOGICA SINICA, 2017, 卷号: 38, 期号: 4
作者:
Zhou, Zhi-rui
;
Yang, Zhao-zhi
;
Wang, Shao-jia
;
Zhang, Li
;
Luo, Ju-rui
收藏
  |  
浏览/下载:7/0
  |  
提交时间:2019/12/05
human triple-negative breast cancer
checkpoint kinase 1
MK-8776
radiosensitivity
autophagy
xenograft tumors
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