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科研机构
上海药物研究所 [27]
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期刊论文 [27]
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2018 [1]
2015 [1]
2012 [3]
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Two distinct domains of the glucagon-like peptide-1 receptor control peptide-mediated biased agonism
期刊论文
JOURNAL OF BIOLOGICAL CHEMISTRY, 2018, 卷号: 293, 期号: 24, 页码: 9370-9387
作者:
Lei, Saifei
;
Clydesdale, Lachlan
;
Dai, Antao
;
Cai, Xiaoqing
;
Feng, Yang
收藏
  |  
浏览/下载:52/0
  |  
提交时间:2019/01/08
G protein-coupled receptor (GPCR)
glucagon
receptor structure-function
cell signaling
site-directed mutagenesis
biased agonism
GLP-1 receptor
glucagon-like peptide-1
class B peptide hormone
ERK kinase
arrestin
transmembrane domain
Structural and biochemical insights into the degradation mechanism of chitosan by chitosanase OU01
期刊论文
BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS, 2015, 卷号: 1850, 期号: 9, 页码: 1953-1961
作者:
Lyu, Qianqian
;
Shi, Yanhong
;
Wang, Song
;
Yang, Yan
;
Han, Baoqin
收藏
  |  
浏览/下载:23/0
  |  
提交时间:2019/01/08
Chitosan
Glycoside hydrolysis
Degradation
Mutagenesis
X-ray crystallography
Assessment of the mutagenic potential of arecoline in gpt delta transgenic mice
期刊论文
MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS, 2012, 卷号: 748, 期号: 1-2, 页码: 65-69
作者:
Wu, Mengjun
;
Xing, Guozhen
;
Qi, Xinming
;
Feng, Chenchen
;
Liu, Mingxia
收藏
  |  
浏览/下载:17/0
  |  
提交时间:2019/01/08
Arecoline
gpt delta transgenic mouse
Mutagenesis
Comparison of the mutagenicity of aristolochic acid I and aristolochic acid II in the gpt delta transgenic mouse kidney
期刊论文
MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS, 2012, 卷号: 743, 期号: 1-2, 页码: 52-58
作者:
Xing, Guozhen
;
Qi, Xinming
;
Chen, Min
;
Wu, Yuanfeng
;
Yao, Jun
收藏
  |  
浏览/下载:11/0
  |  
提交时间:2019/01/08
Aristolochic acid
DNA adducts
Mutagenesis
Ice breaking in GPCR structural biology
期刊论文
ACTA PHARMACOLOGICA SINICA, 2012, 卷号: 33, 期号: 3, 页码: 324-334
作者:
Zhao, Qiang
;
Wu, Bei-li
收藏
  |  
浏览/下载:14/0
  |  
提交时间:2019/01/08
G-protein-coupled receptors (GPCRs)
expression study
mutagenesis
surfactant
crystallization
bicelle
lipidic cubic phase
X-ray crystallographic and enzymatic analyses of shikimate dehydrogenase from Staphylococcus epidermidis
期刊论文
FEBS JOURNAL, 2009, 卷号: 276, 期号: 4, 页码: 1125-1139
作者:
Han, Cong
;
Hu, Tiancen
;
Wu, Dalei
;
Qu, Su
;
Zhou, Jiahai
收藏
  |  
浏览/下载:16/0
  |  
提交时间:2019/01/08
crystal structure
shikimate dehydrogenase
shikimate pathway
site-directed mutagenesis
Staphylococcus epidermidis
The negatively charged amino acids in the lumenal loop influence the pigment binding and conformation of the major light-harvesting chlorophyll a/b complex of photosystem II
期刊论文
BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS, 2008, 卷号: 1777, 期号: 11, 页码: 1463-1470
作者:
Yang, Chunhong
;
Lambrev, Petar
;
Chen, Zhi
;
Javorfi, Tamas
;
Kiss, Anett Z.
收藏
  |  
浏览/下载:12/0
  |  
提交时间:2019/01/08
Major light-harvesting a/b complex of
photosystem II
Spectroscopy
Mutagenesis
Low pH
D77, one benzoic acid derivative, functions as a novel anti-HIV-1 inhibitor targeting the interaction between integrase and cellular LEDGF/p75
期刊论文
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2008, 卷号: 375, 期号: 1, 页码: 139-144
作者:
Du, Li
;
Chen, Jing
;
Yang, Liumeng
;
Zheng, Yongtang
;
Tang, Yun
收藏
  |  
浏览/下载:16/0
  |  
提交时间:2019/01/08
HIV-1 integrase
Lens epithelium-derived growth factor (LEDGF/p75)
yeast two-hybrid assay
surface plasmon resonance (SPR)
molecular docking
site-directed mutagenesis
Symmetrical 1-pyrrolidineacetamide showing anti-HIV activity through a new binding site on HIV-1 integrase
期刊论文
ACTA PHARMACOLOGICA SINICA, 2008, 卷号: 29, 期号: 10, 页码: 1261-1267
作者:
Du, Li
;
Zhao, Ya-xue
;
Yang, Liu-meng
;
Zheng, Yong-tang
;
Tang, Yun
收藏
  |  
浏览/下载:13/0
  |  
提交时间:2019/01/08
HIV-1 integrase inhibitor
surface plasma resonance
molecular docking
site-directed mutagenesis
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