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科研机构
上海药物研究所 [116]
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期刊论文 [116]
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2021 [4]
2020 [2]
2019 [4]
2018 [7]
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Pharmacol... [21]
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Cryo-EM structures of PI3K alpha reveal conformational changes during inhibition and activation
期刊论文
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2021, 卷号: 118, 期号: 45, 页码: 9
作者:
Liu, Xiao
;
Yang, Su
;
Hart, Jonathan R.
;
Xu, Yingna
;
Zou, Xinyu
收藏
  |  
浏览/下载:40/0
  |  
提交时间:2022/01/04
phosphoinositide 3-kinase (PI3K)
activation
inhibition
activity-dependent conformational changes
Synthesis and bioactivity studies of covalent inhibitors derived from (-)-Chaetominine
期刊论文
JOURNAL OF MOLECULAR STRUCTURE, 2021, 卷号: 1241, 页码: 14
作者:
Zhou, Xian
;
Feng, Xuexin
;
Wang, Dachi
;
Chen, Deheng
;
Wu, Gaoxing
收藏
  |  
浏览/下载:85/0
  |  
提交时间:2021/08/17
Chaetominine
Cellular growth inhibition
Cancer cell line
Covalent warhead
Engineering Chameleon Prodrug Nanovesicles to Increase Antigen Presentation and Inhibit PD-L1 Expression for Circumventing Immune Resistance of Cancer
期刊论文
ADVANCED MATERIALS, 2021, 页码: 12
作者:
Zhou, Fengqi
;
Gao, Jing
;
Tang, Yang
;
Zou, Zhifeng
;
Jiao, Shi
收藏
  |  
浏览/下载:38/0
  |  
提交时间:2021/11/04
antigen presentation
autophagy inhibition
immune resistance
immunotherapy
prodrug nanovesicles
Cytochrome P450-Mediated Metabolism and CYP Inhibition for the Synthetic Peroxide Antimalarial OZ439
期刊论文
ACS INFECTIOUS DISEASES, 2021, 卷号: 7, 期号: 7, 页码: 1885-1893
作者:
Shackleford, David M.
;
Chiu, Francis C. K.
;
Katneni, Kasiram
;
Blundell, Scott
;
McLaren, Jenna
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  |  
浏览/下载:59/0
  |  
提交时间:2021/11/04
OZ439 (artefenomel)
malaria
metabolite identification
cytochrome P450 metabolism
cytochrome P450 inhibition
time-dependent inhibition
Four undescribed sulfur-containing indole alkaloids with nitric oxide inhibitory activities from Isatis tinctoria L. roots
期刊论文
PHYTOCHEMISTRY, 2020, 卷号: 174, 页码: 6
作者:
Zhang, Dongdong
;
Ruan, Deqing
;
Li, Jingyi
;
Chen, Zhaoqiang
;
Zhu, Weiliang
收藏
  |  
浏览/下载:36/0
  |  
提交时间:2020/07/01
Isatis tinctoria L.
Brassicaceae
Indole alkaloids
Isatisindigoticanines H and I
Isatindigosides F and G
Nitric oxide inhibition
Spirobiflavonoid stereoisomers from the endangered conifer Glyptostrobus pensilis and their protein tyrosine phosphatase 1B inhibitory activity
期刊论文
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2020, 卷号: 30, 期号: 4, 页码: 4
作者:
Xiong, Juan
;
Hu, Chang-Ling
;
Wang, Pei-Pei
;
Gao, Ding-Ding
;
Huang, Fang
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  |  
浏览/下载:45/0
  |  
提交时间:2020/07/01
Glyptostrobus pensilis
Cupressaceae
Endangered conifer
Spirobiflavonoids
PTP1B inhibition
Design, synthesis, and biological evaluation of thieno[3,2-d]pyrimidine derivatives as potential simplified phosphatidylinositol 3-kinase alpha inhibitors
期刊论文
CHEMICAL BIOLOGY & DRUG DESIGN, 2019, 卷号: 94, 期号: 6, 页码: 2013-2022
作者:
Yang, Xiuyan
;
Deng, Meng
;
Zhang, Xi
;
Wang, Yi
;
Song, Kun
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  |  
浏览/下载:75/0
  |  
提交时间:2020/07/01
PI3K alpha inhibitors
proliferation inhibition
thieno[3
2-d]pyrimidine derivatives
New NO production inhibitors from Hyssopus cuspidatus in LPS-induced RAW264.7 cells
期刊论文
PHYTOCHEMISTRY LETTERS, 2019, 卷号: 34, 页码: 91-95
作者:
Liu, Dan
;
Yin, Qiang
;
Zhang, Qihua
;
Xiang, Jin
;
Ruan, Changlei
收藏
  |  
浏览/下载:17/0
  |  
提交时间:2020/07/01
Hyssopus cuspidatus
Sesquiterpenes
NO production inhibition
Identification of new dual FABP4/5 inhibitors based on a naphthalene-1-sulfonamide FABP4 inhibitor
期刊论文
BIOORGANIC & MEDICINAL CHEMISTRY, 2019, 卷号: 27, 期号: 19, 页码: 16
作者:
He, Yulong
;
Dou, Huixia
;
Gao, Dingding
;
Wang, Ting
;
Zhang, Mingming
收藏
  |  
浏览/下载:17/0
  |  
提交时间:2020/07/01
Dual FABP4/5 inhibitor
Structure-based design
Lipolysis inhibition
Anti-inflammatory effects
Design and synthesis of novel dual-cyclic RGD peptides for alpha(v)beta(3) integrin targeting
期刊论文
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2019, 卷号: 29, 期号: 7, 页码: 896-900
作者:
Liu, Junjie
;
Cheng, Xiaozhong
;
Tian, Xiaobo
;
Guan, Dongliang
;
Ao, Jiwei
收藏
  |  
浏览/下载:17/0
  |  
提交时间:2020/07/01
alpha(v)beta(3) integrin
RGD cyclic peptide
Tumor-targeting
Cyclo(RGDfK)
Adhesion inhibition
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