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科研机构
上海药物研究所 [122]
内容类型
期刊论文 [122]
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2021 [6]
2020 [9]
2019 [4]
2018 [5]
2017 [9]
2016 [11]
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Novel tetrahydrobenzo[b]thiophen-2-yl)urea derivatives as novel alpha-glucosidase inhibitors: Synthesis, kinetics study, molecular docking, and in vivo anti-hyperglycemic evaluation
期刊论文
BIOORGANIC CHEMISTRY, 2021, 卷号: 115, 页码: 17
作者:
Xie, Hong-Xu
;
Zhang, Juan
;
Li, Yue
;
Zhang, Jin-He
;
Liu, Shan-Kui
收藏
  |  
浏览/下载:68/0
  |  
提交时间:2021/11/04
Tetrahydrobenzo[b]thiophen-2-yl)urea
alpha-Glucosidase inhibitors
Non-competitive inhibitor
Molecular docking
Anti-hyperglycaemic activity
Type 2 diabetes
Further new nardosinane-type sesquiterpenoids from the Xisha soft coral Litophyton nigrum
期刊论文
FITOTERAPIA, 2021, 卷号: 151, 页码: 4
作者:
Yang, Fan
;
Hua, Qiang
;
Yao, Li-Gong
;
Liang, Lin-Fu
;
Lu, Yan-Hua
收藏
  |  
浏览/下载:18/0
  |  
提交时间:2021/08/17
Soft coral
Litophyton nigrum
Nardosinane
Anti-nociceptive, anti-inflammatory and anti-arthritic activities of pregnane glycosides from the root bark of Periploca sepium Bunge
期刊论文
JOURNAL OF ETHNOPHARMACOLOGY, 2021, 卷号: 265, 页码: 12
作者:
Lin, Ze-min
;
Liu, Yu-ting
;
Huang, Yue-teng
;
Yang, Xiao-qian
;
Zhu, Feng-hua
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  |  
浏览/下载:43/0
  |  
提交时间:2021/05/24
Periploca sepium Bunge
Pregnane glycosides
Anti-nociceptive activity
Anti-inflammatory activity
Anti-arthritic activity
Inflammatory arthritis
A novel tricyclic BTK inhibitor suppresses B cell responses and osteoclastic bone erosion in rheumatoid arthritis
期刊论文
ACTA PHARMACOLOGICA SINICA, 2021, 页码: 12
作者:
Liu, Yu-ting
;
Ding, Hui-hua
;
Lin, Ze-min
;
Wang, Que
;
Chen, Li
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  |  
浏览/下载:24/0
  |  
提交时间:2021/05/24
rheumatoid arthritis
BTK inhibitors
B cells
macrophages
RANKL
osteoclastogenesis
Identification of methyl (5-(6-((4-(methylsulfonyl)piperazin-1-yl)methyl)-4-morpholinopyrrolo[2,1-f][1,2,4]triazin-2-yl)-4-(trifluoromethyl)pyridin-2-yl)carbamate (CYH33) as an orally bioavailable, highly potent, PI3K alpha inhibitor for the treatment of advanced solid tumors
期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2021, 卷号: 209, 页码: 10
作者:
Xiang, Hao-Yue
;
Wang, Xiang
;
Chen, Yan-Hong
;
Zhang, Xi
;
Tan, Cun
收藏
  |  
浏览/下载:33/0
  |  
提交时间:2021/05/24
PI3K
Pyrrolo[2,1-f][1,2,4]triazine
Anti-cancer
Target therapy
Novel Plasma miRNAs as Biomarkers and Therapeutic Targets of Alzheimer's Disease at the Prodromal Stage
期刊论文
JOURNAL OF ALZHEIMERS DISEASE, 2021, 卷号: 83, 期号: 2, 页码: 779-790
作者:
He, Haining
;
Liu, An
;
Zhang, Wei
;
Yang, Huanqing
;
Zhang, Minmin
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  |  
浏览/下载:27/0
  |  
提交时间:2021/11/04
Alzheimer's disease
biomarkers
microRNAs
mild cognitive impairment
Limonoids from Cipadessa baccifera
期刊论文
JOURNAL OF NATURAL PRODUCTS, 2020, 卷号: 83, 期号: 6, 页码: 1751-1765
作者:
Yu, Jin-Hai
;
Zhang, Hua
;
Zhou, Bin
;
Zimbres, Flavia M.
;
Dalal, Seema
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  |  
浏览/下载:8/0
  |  
提交时间:2020/12/24
Design, synthesis and antiproliferative activity evaluation of a series of pyrrolo [2,1-f] [1,2,4] triazine derivatives
期刊论文
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2020, 卷号: 30, 期号: 12, 页码: 4
作者:
Xiang, Hao-Yue
;
Chen, Yan-Hong
;
Wang, Yi
;
Zhang, Xi
;
Ding, Jian
收藏
  |  
浏览/下载:38/0
  |  
提交时间:2020/07/01
Antiproliferative
Cancer
Therapy
PI3K inhibitors
Pyrrolo [2,1-f][1,2,4] triazine
Kinase
High-throughput screening campaign identifies a small molecule agonist of the relaxin family peptide receptor 4
期刊论文
ACTA PHARMACOLOGICA SINICA, 2020, 页码: 9
作者:
Lin, Guang-yao
;
Lin, Lin
;
Cai, Xiao-qing
;
Dai, An-tao
;
Zhu, Yue
收藏
  |  
浏览/下载:27/0
  |  
提交时间:2020/07/01
RXFP4
INSL5
high-throughput screening
agonist
JK1
Daphnillonins A and B: Alkaloids Representing Two Unknown Carbon Skeletons from Daphniphyllum longeracemosum
期刊论文
JOURNAL OF ORGANIC CHEMISTRY, 2020, 卷号: 85, 期号: 5, 页码: 3742-3747
作者:
Zhang, Dong-Dong
;
Xu, Jin-Biao
;
Fan, Yao-Yue
;
Gan, Li-She
;
Zhang, Hua
收藏
  |  
浏览/下载:7/0
  |  
提交时间:2020/07/01
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