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科研机构
上海药物研究所 [10]
内容类型
期刊论文 [10]
发表日期
2021 [10]
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发表日期:2021
专题:上海药物研究所
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Potent and Selective RIPK1 Inhibitors Targeting Dual-Pockets for the Treatment of Systemic Inflammatory Response Syndrome and Sepsis
期刊论文
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2021, 页码: 6
作者:
Yang, Xiangbo
;
Lu, Huimin
;
Xie, Hang
;
Zhang, Binbin
;
Nie, Tianqing
收藏
  |  
浏览/下载:24/0
  |  
提交时间:2022/01/18
Binding studies
Drug discovery
Necroptosis
RIPK1 inhibitors
Sepsis
Distal mutation V486M disrupts the catalytic activity of DPP4 by affecting the flap of the propeller domain
期刊论文
ACTA PHARMACOLOGICA SINICA, 2021, 页码: 9
作者:
Li, Teng-teng
;
Peng, Cheng
;
Wang, Ji-qiu
;
Xu, Zhi-jian
;
Su, Ming-bo
收藏
  |  
浏览/下载:42/0
  |  
提交时间:2022/01/18
DPP4
distal mutation
enzymatic activity
molecular dynamics simulation
structure-function mechanism
Cryo-EM structures of PI3K alpha reveal conformational changes during inhibition and activation
期刊论文
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2021, 卷号: 118, 期号: 45, 页码: 9
作者:
Liu, Xiao
;
Yang, Su
;
Hart, Jonathan R.
;
Xu, Yingna
;
Zou, Xinyu
收藏
  |  
浏览/下载:39/0
  |  
提交时间:2022/01/04
phosphoinositide 3-kinase (PI3K)
activation
inhibition
activity-dependent conformational changes
Identification of phosphodiesterase-4 as the therapeutic target of arctigenin in alleviating psoriatic skin inflammation
期刊论文
JOURNAL OF ADVANCED RESEARCH, 2021, 卷号: 33, 页码: 241-251
作者:
Li, Heng
;
Zhang, Xianglei
;
Xiang, Caigui
;
Feng, Chunlan
;
Fan, Chen
收藏
  |  
浏览/下载:86/0
  |  
提交时间:2021/11/04
PDE4
Arctigenin
Psoriasis
Inflammation
5-Aminonaphthalene derivatives as selective nonnucleoside nuclear receptor binding SET domain-protein 2 (NSD2) inhibitors for the treatment of multiple myeloma
期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2021, 卷号: 222, 页码: 19
作者:
Wang, Shuni
;
Yang, Hong
;
Su, Mingbo
;
Lian, Fulin
;
Cong, Zhanqing
收藏
  |  
浏览/下载:80/0
  |  
提交时间:2021/11/04
NSD2
Methyltransferase
HTS
Multiple myeloma
5-Aminonaphthalene derivatives
Inhibitor
Pharmacodynamic, pharmacokinetic, and phase 1a study of bisthianostat, a novel histone deacetylase inhibitor, for the treatment of relapsed or refractory multiple myeloma
期刊论文
ACTA PHARMACOLOGICA SINICA, 2021, 页码: 9
作者:
Zhou, Yu-bo
;
Zhang, Yang-ming
;
Huang, Hong-hui
;
Shen, Li-jing
;
Han, Xiao-feng
收藏
  |  
浏览/下载:92/0
  |  
提交时间:2021/11/04
multiple myeloma
HDAC inhibitor
bisthianostat
pharmacodynamics
pharmacokinetics
phase 1a clinical trial
antitumor drug
Simple and robust differentiation of Ganoderma species by high performance thin-layer chromatography coupled with single quadrupole mass spectrometry QDa
期刊论文
CHINESE JOURNAL OF NATURAL MEDICINES, 2021, 卷号: 19, 期号: 4, 页码: 295-304
作者:
Yao Shuai
;
Zhang Jian-Qing
;
Hou Jin-Jun
;
Hu Xiao-Su
;
Wang Ling
收藏
  |  
浏览/下载:55/0
  |  
提交时间:2021/06/11
High performance thin-layer chromatography
Mass spectrometry QDa
Ganoderma
Authentication
Simple and robust differentiation of Ganoderma species by high performance thin-layer chromatography coupled with single quadrupole mass spectrometry QDa
期刊论文
CHINESE JOURNAL OF NATURAL MEDICINES, 2021, 卷号: 19, 期号: 4, 页码: 295-304
作者:
Yao Shuai
;
Zhang Jian-Qing
;
Hou Jin-Jun
;
Hu Xiao-Su
;
Wang Ling
收藏
  |  
浏览/下载:57/0
  |  
提交时间:2021/06/11
High performance thin-layer chromatography
Mass spectrometry QDa
Ganoderma
Authentication
Design, synthesis, and biological evaluation of tetrahydroisoquinolines derivatives as novel, selective PDE4 inhibitors for antipsoriasis treatment
期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2021, 卷号: 211, 页码: 20
作者:
Zhang, Rui
;
Li, Heng
;
Zhang, Xianglei
;
Li, Jian
;
Su, Haixia
收藏
  |  
浏览/下载:22/0
  |  
提交时间:2021/05/24
PDE4 inhibitors
Tetrahydroisoquinoline
Antipsoriasis
Identification of methyl (5-(6-((4-(methylsulfonyl)piperazin-1-yl)methyl)-4-morpholinopyrrolo[2,1-f][1,2,4]triazin-2-yl)-4-(trifluoromethyl)pyridin-2-yl)carbamate (CYH33) as an orally bioavailable, highly potent, PI3K alpha inhibitor for the treatment of advanced solid tumors
期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2021, 卷号: 209, 页码: 10
作者:
Xiang, Hao-Yue
;
Wang, Xiang
;
Chen, Yan-Hong
;
Zhang, Xi
;
Tan, Cun
收藏
  |  
浏览/下载:33/0
  |  
提交时间:2021/05/24
PI3K
Pyrrolo[2,1-f][1,2,4]triazine
Anti-cancer
Target therapy
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