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浏览/检索结果: 共18条，第1-10条 帮助 限定条件 发表日期：2021    内容类型：期刊论文    专题：上海药物研究所    第一署名单位    第一作者单位    通讯作者单位     已选(0)清除 条数/页：5101520253035404550556065707580859095100   排序方式：请选择作者升序作者降序题名升序题名降序发表日期升序发表日期降序提交时间升序提交时间降序 Discovery and Development of a Potent, Selective, and Orally Bioavailable CHK1 Inhibitor Candidate: 5-((4-((3-Amino-3-methylbutyl)amino)-5-(trifluoromethyl)pyrimidin-2-yl)amino)picolinonitrile 期刊论文 JOURNAL OF MEDICINAL CHEMISTRY, 2021, 卷号: 64, 期号: 20, 页码: 15069-15090 作者:  Jin, Tingting;  Xu, Lei;  Wang, Peipei;  Hu, Xiaobei;  Zhang, Runyuan 收藏  |  浏览/下载：23/0  |  提交时间：2022/01/04 DRAK2 aggravates nonalcoholic fatty liver disease progression through SRSF6-associated RNA alternative splicing 期刊论文 CELL METABOLISM, 2021, 卷号: 33, 期号: 10, 页码: 2004-+ 作者:  Li, Yufeng;  Xu, Junyu;  Lu, Yuting;  Bian, Hua;  Yang, Lin 收藏  |  浏览/下载：23/0  |  提交时间：2022/01/18 Synthesis and Evaluation of 3-(Indol-3-yl)-4-(Pyrazolo[3,4-c]Pyridazin-3-yl)-Maleimides as Potent Mutant Isocitrate Dehydrogenase-1 Inhibitors 期刊论文 PHARMACEUTICAL CHEMISTRY JOURNAL, 2021, 卷号: 55, 期号: 7, 页码: 655-664 作者:  Xu, Jianghong;  Hu, Yuanyuan;  Liu, Xiaoqi;  Gao, Anhui;  Gao, Lixin 收藏  |  浏览/下载：37/0  |  提交时间：2021/12/01 IDH1-R132H inhibitors  synthesis  biological activity  docking  3-(indol-3-yl)-4-(pyrazolo-[3  4-c]pyridazin-3-yl)-maleimides   Discovery of a Potential Liver Fibrosis Inhibitor from a Mushroom Endophytic Fungus by Genome Mining of a Silent Biosynthetic Gene Cluster 期刊论文 JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 2021, 卷号: 69, 期号: 38, 页码: 11303-11310 作者:   收藏  |  浏览/下载：28/0  |  提交时间：2021/12/01 fungus  Calcarisporium arbuscula  natural product  gene cluster activation  liver fibrosis   Systematic investigation on the anti-rheumatoid arthritis material basis and mechanism of Juan Bi Tang. Part 1: Integrating metabolic profiles and network pharmacology 期刊论文 JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS, 2021, 卷号: 202, 页码: 11 作者:  Li, Jiajia;  Li, Lei;  Wang, Yangyang;  Zhao, Yuxuan;  Hu, Pei 收藏  |  浏览/下载：41/0  |  提交时间：2021/08/17 Juanbi-Tang (JBT)  Rheumatoid arthritis (RA)  Metabolites  Mass  Network pharmacology  Molecular docking   Discovery of potential small molecular SARS-CoV-2 entry blockers targeting the spike protein 期刊论文 ACTA PHARMACOLOGICA SINICA, 2021, 页码: 9 作者:  Wang, Lin;  Wu, Yan;  Yao, Sheng;  Ge, Huan;  Zhu, Ya 收藏  |  浏览/下载：86/0  |  提交时间：2021/11/04 SARS-CoV-2  natural products  virtual screening  spike protein  protein-protein interaction modulators   Discovery of SARS-CoV-2-E channel inhibitors as antiviral candidates 期刊论文 ACTA PHARMACOLOGICA SINICA, 2021, 页码: 7 作者:  Wang, Yi;  Fang, Sui;  Wu, Yan;  Cheng, Xi;  Zhang, Lei-ke 收藏  |  浏览/下载：103/0  |  提交时间：2021/08/17 SARS-CoV-2  envelope protein (2-E)  cation channel  high-throughput screening (HTS)  anti-virus   SARS-CoV-2 envelope protein causes acute respiratory distress syndrome (ARDS)-like pathological damages and constitutes an antiviral target 期刊论文 CELL RESEARCH, 2021, 页码: 14 作者:  Xia, Bingqing;  Shen, Xurui;  He, Yang;  Pan, Xiaoyan;  Liu, Feng-Liang 收藏  |  浏览/下载：78/0  |  提交时间：2021/08/17 Discovery of thalidomide-based PROTAC small molecules as the highly efficient SHP2 degraders 期刊论文 EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2021, 卷号: 218, 页码: 14 作者:  Yang, Xiangbo;  Wang, Zhijia;  Pei, Yuan;  Song, Ning;  Xu, Lei 收藏  |  浏览/下载：40/0  |  提交时间：2021/08/17 SHP2 degradation  Proteolysis targeting chimera (PROTAC)  Thalidomide-based heterobifunctional molecules  E3 ubiquitin ligase  CRBN   Structural basis of human alpha 7 nicotinic acetylcholine receptor activation 期刊论文 CELL RESEARCH, 2021, 页码: 4 作者:  Zhao, Yue;  Liu, Sanling;  Zhou, Yingxin;  Zhang, Mengge;  Chen, Haopeng 收藏  |  浏览/下载：19/0  |  提交时间：2021/06/11