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科研机构
上海药物研究所 [10]
内容类型
期刊论文 [10]
发表日期
2020 [10]
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发表日期:2020
专题:上海药物研究所
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Targeted Proteomics Combined with Affinity Mass Spectrometry Analysis Reveals Antagonist E7 Acts As an Intracellular Covalent Ligand of Orphan Receptor GPR52
期刊论文
ACS CHEMICAL BIOLOGY, 2020, 卷号: 15, 期号: 12, 页码: 3275-3284
作者:
Ma, Mengna
;
Guo, Shimeng
;
Lin, Xi
;
Li, Shanshan
;
Wu, Yiran
收藏
  |  
浏览/下载:16/0
  |  
提交时间:2021/05/24
Crystallography-guided discovery of carbazole-based retinoic acid-related orphan receptor gamma-t (ROR gamma t) modulators: insights into different protein behaviors with "short" and "long" inverse agonists
期刊论文
ACTA PHARMACOLOGICA SINICA, 2020, 页码: 11
作者:
Yu, Ming-cheng
;
Yang, Feng
;
Ding, Xiao-yu
;
Sun, Nan-nan
;
Jiang, Zheng-yuan
收藏
  |  
浏览/下载:85/0
  |  
提交时间:2020/12/24
RORγ
t
cocrystal structures
MD simulation
“
short”
inverse agonists
agonists
“
long”
inverse agonists
Drug interaction of ningetinib and gefitinib involving CYP1A1 and efflux transporters in non-small cell lung cancer patients
期刊论文
BRITISH JOURNAL OF CLINICAL PHARMACOLOGY, 2020, 页码: 13
作者:
Liu, Lu
;
Wang, Qian
;
Xie, Cen
;
Xi, Ning
;
Guo, Zitao
收藏
  |  
浏览/下载:55/0
  |  
提交时间:2020/12/24
drug–
drug interaction
gefitinib
ningetinib
transporters
Discovery and Optimization of Non-bile Acid FXR Agonists as Preclinical Candidates for the Treatment of Nonalcoholic Steatohepatitis
期刊论文
JOURNAL OF MEDICINAL CHEMISTRY, 2020, 卷号: 63, 期号: 21, 页码: 12748-12772
作者:
Li, Junyou
;
Liu, Mengqi
;
Li, Yazhou
;
Sun, Dan-dan
;
Shu, Zhihao
收藏
  |  
浏览/下载:22/0
  |  
提交时间:2021/05/24
A potential drug combination of omeprazole and patchouli alcohol significantly normalizes oxidative stress and inflammatory responses against gastric ulcer in ethanol-induced rat model
期刊论文
INTERNATIONAL IMMUNOPHARMACOLOGY, 2020, 卷号: 85, 页码: 9
作者:
Xie, Lu
;
Guo, Yi-lin
;
Chen, Yu-rou
;
Zhang, Li-ying
;
Wang, Zhi-cheng
收藏
  |  
浏览/下载:29/0
  |  
提交时间:2020/12/24
Gastric ulcer
Omeprazole
Patchouli alcohol
Structural basis of GPBAR activation and bile acid recognition
期刊论文
NATURE, 2020, 页码: 29
作者:
Yang, Fan
;
Mao, Chunyou
;
Guo, Lulu
;
Lin, Jingyu
;
Ming, Qianqian
收藏
  |  
浏览/下载:46/0
  |  
提交时间:2020/12/24
Effects of Paeonol and Gastroretention Tablets of Paeonol on Experimental Gastric Ulcers and Intestinal Flora in Rats
期刊论文
INFLAMMATION, 2020, 页码: 13
作者:
Guo, Yilin
;
Du, Yaoyao
;
Xie, Lu
;
Pu, Yiqiong
;
Yuan, Jianlong
收藏
  |  
浏览/下载:18/0
  |  
提交时间:2020/12/24
gastric ulcer
paeonol
gastroretention tablets of paeonol
pyloric ligation
acetic acid
intestinal flora
Systematic investigation on the chemical basis of anti-NAFLD Qushi Huayu Fang. Part 1: A study of metabolic profiles in vivo and in vitro by high-performance liquid chromatography-quadrupole time-of-flight mass spectrometry
期刊论文
BIOMEDICAL CHROMATOGRAPHY, 2020, 页码: 15
作者:
Liu, Huan
;
Sun, Zhaolin
;
Tian, Xiaoting
;
Feng, Qin
;
Guo, Ziqiong
收藏
  |  
浏览/下载:36/0
  |  
提交时间:2020/07/01
HPLC-Q-TOF
intestinal bacteria
liver
metabolism
Qushi Huayu Fang
Structural basis of ligand recognition and self-activation of orphan GPR52
期刊论文
NATURE, 2020, 页码: 21
作者:
Lin, Xi
;
Li, Mingyue
;
Wang, Niandong
;
Wu, Yiran
;
Luo, Zhipu
收藏
  |  
浏览/下载:176/0
  |  
提交时间:2020/07/01
Leflunomide increased the renal exposure of acyclovir by inhibiting OAT1/3 and MRP2
期刊论文
ACTA PHARMACOLOGICA SINICA, 2020, 卷号: 41, 期号: 1, 页码: 129-137
作者:
Liao, Xiao-ying
;
Deng, Qiang-qiang
;
Han, Li
;
Wu, Zhi-tao
;
Peng, Zhao-liang
收藏
  |  
浏览/下载:55/0
  |  
提交时间:2020/07/01
leflunomide
teriflunomide
acyclovir
organic anion transporter
multidrug resistance associated protein (MRP) 2
drug-drug interaction
pharmacokinetics
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