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上海药物研究所 [166]
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期刊论文 [166]
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Identification of phosphodiesterase-4 as the therapeutic target of arctigenin in alleviating psoriatic skin inflammation
期刊论文
JOURNAL OF ADVANCED RESEARCH, 2021, 卷号: 33, 页码: 241-251
作者:
Li, Heng
;
Zhang, Xianglei
;
Xiang, Caigui
;
Feng, Chunlan
;
Fan, Chen
收藏
  |  
浏览/下载:87/0
  |  
提交时间:2021/11/04
PDE4
Arctigenin
Psoriasis
Inflammation
Structural mechanism of calcium-mediated hormone recognition and G beta interaction by the human melanocortin-1 receptor
期刊论文
CELL RESEARCH, 2021, 页码: 11
作者:
Ma, Shanshan
;
Chen, Yan
;
Dai, Antao
;
Yin, Wanchao
;
Guo, Jia
收藏
  |  
浏览/下载:24/0
  |  
提交时间:2021/11/04
Recent Progress and Clinical Development of Inhibitors that Block MDM4/p53 Protein-Protein Interactions
期刊论文
JOURNAL OF MEDICINAL CHEMISTRY, 2021, 卷号: 64, 期号: 15, 页码: 10621-10640
作者:
Zhang, Shiyan
;
Lou, Jianfeng
;
Li, Yafang
;
Zhou, Feilong
;
Yan, Ziqin
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  |  
浏览/下载:64/0
  |  
提交时间:2021/11/04
Molecular simulation studies of the interactions between the human/ pangolin/cat/bat ACE2 and the receptor binding domain of the SARS-CoV-2 spike protein
期刊论文
BIOCHIMIE, 2021, 卷号: 187, 页码: 1-13
作者:
Ma, Shaojie
;
Li, Hui
;
Yang, Jun
;
Yu, Kunqian
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  |  
浏览/下载:68/0
  |  
提交时间:2021/08/17
SARS-CoV-2
ACE2
Molecular simulation
Binding energy
Animal hosts
Discovery of Novel Allosteric Modulators Targeting an Extra-Helical Binding Site of GLP-1R Using Structure- and Ligand-Based Virtual Screening
期刊论文
BIOMOLECULES, 2021, 卷号: 11, 期号: 7, 页码: 14
作者:
Zhou, Qingtong
;
Guo, Wanjing
;
Dai, Antao
;
Cai, Xiaoqing
;
Vass, Marton
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  |  
浏览/下载:41/0
  |  
提交时间:2021/08/17
GLP-1R
virtual screening
allosteric modulator
drug discovery
molecular docking
Polyoxypregnanes as safe, potent, and specific ABCB1-inhibitory pro-drugs to overcome multidrug resistance in cancer chemotherapy in vitro and in vivo
期刊论文
ACTA PHARMACEUTICA SINICA B, 2021, 卷号: 11, 期号: 7, 页码: 1885-1902
作者:
Wu, Xu
;
Yin, Chun
;
Ma, Jiang
;
Chai, Stella
;
Zhang, Chunyuan
收藏
  |  
浏览/下载:39/0
  |  
提交时间:2021/11/04
Multidrug resistance
ABCB1
Polyoxypregnane
Combination chemotherapy
Marsdenia tenacissima
Molecular Dynamics Simulations Reveal the Modulated Mechanism of STING Conformation
期刊论文
INTERDISCIPLINARY SCIENCES-COMPUTATIONAL LIFE SCIENCES, 2021, 页码: 15
作者:
Chen, Li
;
Zhao, Shuang
;
Zhu, Yanyan
;
Liu, Yongsheng
;
Li, Huiyu
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  |  
浏览/下载:29/0
  |  
提交时间:2021/08/17
STING
Small molecule
Binding site
Modulated mechanism
Molecular dynamics simulation
pi-pi stacking interaction
Phage-Display Based Discovery and Characterization of Peptide Ligands against WDR5
期刊论文
MOLECULES, 2021, 卷号: 26, 期号: 5, 页码: 12
作者:
Cao, Jiawen
;
Fan, Tiantian
;
Li, Yanlian
;
Du, Zhiyan
;
Chen, Lin
收藏
  |  
浏览/下载:70/0
  |  
提交时间:2021/05/24
phage display
biopanning
WDR5
cocrystal structure
Glucose-Binding of Periplasmic Protein GltB Activates GtrS-GltR Two-Component System in Pseudomonas aeruginosa
期刊论文
MICROORGANISMS, 2021, 卷号: 9, 期号: 2, 页码: 28
作者:
Xu, Chenchen
;
Cao, Qiao
;
Lan, Lefu
收藏
  |  
浏览/下载:111/0
  |  
提交时间:2021/05/24
Pseudomonas aeruginosa
Glucose
periplasmic binding protein
two-component system
transcriptional regulation
Increasing the Sampling Efficiency of Protein Conformational Change by Combining a Modified Replica Exchange Molecular Dynamics and Normal Mode Analysis
期刊论文
JOURNAL OF CHEMICAL THEORY AND COMPUTATION, 2021, 卷号: 17, 期号: 1, 页码: 13-28
作者:
Peng, Cheng
;
Wang, Jinan
;
Shi, Yulong
;
Xu, Zhijian
;
Zhu, Weiliang
收藏
  |  
浏览/下载:22/0
  |  
提交时间:2021/05/24
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