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科研机构
上海药物研究所 [18]
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期刊论文 [18]
发表日期
2018 [1]
2017 [5]
2016 [1]
2015 [2]
2014 [1]
2012 [2]
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Chemistry [1]
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Alzheimer's disease hypothesis and related therapies
期刊论文
TRANSLATIONAL NEURODEGENERATION, 2018, 卷号: 7
作者:
Du, Xiaoguang
;
Wang, Xinyi
;
Geng, Meiyu
收藏
  |  
浏览/下载:22/0
  |  
提交时间:2019/01/08
Alzheimer's disease
complicated disease
anti-AD drugs
Hypothesis about AD
Defining the minimum substrate and charge recognition model of gamma-secretase
期刊论文
ACTA PHARMACOLOGICA SINICA, 2017, 卷号: 38, 期号: 10, 页码: 1412-1424
作者:
Yan, Yan
;
Xu, Ting-Hai
;
Melcher, Karsten
;
Xu, H. Eric
收藏
  |  
浏览/下载:15/0
  |  
提交时间:2019/01/08
Alzheimer's disease
amyloid beta (A beta)
amyloid precursor protein (APP)
C99, gamma-secretase
minimum substrate
Notch protein
recognition model
Dimerization of the transmembrane domain of amyloid precursor protein is determined by residues around the gamma - secretase cleavage sites
期刊论文
JOURNAL OF BIOLOGICAL CHEMISTRY, 2017, 卷号: 292, 期号: 38, 页码: 15826-15837
作者:
Yan, Yan
;
Xu, Ting-Hai
;
Harikumar, Kaleeckal G.
;
Miller, Laurence J.
;
Melcher, Karsten
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  |  
浏览/下载:17/0
  |  
提交时间:2019/01/08
Research advances in the treatment of Alzheimer's disease with polysaccharides from traditional Chinese medicine
期刊论文
CHINESE JOURNAL OF NATURAL MEDICINES, 2017, 卷号: 15, 期号: 9, 页码: 641-652
作者:
Liu Qin
;
Wang Shun-Chun
;
Ding Kan
收藏
  |  
浏览/下载:15/0
  |  
提交时间:2019/01/08
Alzheimer's disease
Polysaccharides
Traditional Chinese medicine
Amyloid beta: structure, biology and structure-based therapeutic development
期刊论文
ACTA PHARMACOLOGICA SINICA, 2017, 卷号: 38, 期号: 9, 页码: 1205-1235
作者:
Chen, Guo-fang
;
Xu, Ting-hai
;
Yan, Yan
;
Zhou, Yu-ren
;
Jiang, Yi
收藏
  |  
浏览/下载:29/0
  |  
提交时间:2019/01/08
amyloid beta peptide
amyloid precursor protein
Alzheimer's disease
neurodegenerative diseases
drug discovery
amyloidbetastructurebiologyandstructurebasedtherapeuticdevelopment
期刊论文
actapharmacologicasinica, 2017, 卷号: 38, 期号: 9, 页码: 1205
作者:
Chen Guofang
;
Xu Tinghai
;
Yan Yan
;
Zhou Yuren
;
Jiang Yi
收藏
  |  
浏览/下载:49/0
  |  
提交时间:2020/07/01
BLOOD-BRAIN-BARRIER
INSULIN-DEGRADING ENZYME
SOLID-STATE NMR
NICOTINIC ACETYLCHOLINE-RECEPTORS
METABOTROPIC GLUTAMATE RECEPTORS
ATOMIC-FORCE MICROSCOPY
GAMMA-SECRETASE COMPLEX
SMOOTH-MUSCLE-CELLS
AMELIORATES MEMORY IMPAIRMENT
ENDOTHELIN-CONVERTING ENZYME
amyloid beta peptide
amyloid precursor protein
Alzheimer's disease
neurodegenerative diseases
drug discovery
Alzheimer's disease-associated mutations increase amyloid precursor protein resistance to gamma-secretase cleavage and the A beta 42/A beta 40 ratio
期刊论文
CELL DISCOVERY, 2016, 卷号: 2
作者:
Xu, Ting-Hai
;
Yan, Yan
;
Kang, Yanyong
;
Jiang, Yi
;
Melcher, Karsten
收藏
  |  
浏览/下载:21/0
  |  
提交时间:2019/01/08
Alzheimer's disease
C99
gamma-secretase
familial Alzheimer disease (FAD)-linked mutations
epsilon-cleavage assay
The cryo-electron microscopy structure of gamma-secretase: towards complex assembly, substrate recognition and a catalytic mechanism
期刊论文
NATIONAL SCIENCE REVIEW, 2015, 卷号: 2, 期号: 1, 页码: 4-5
作者:
Kang, Yanyong
;
Melcher, Karsten
;
Xu, H. Eric
收藏
  |  
浏览/下载:11/0
  |  
提交时间:2019/01/08
Targeting the gamma-/beta-secretase interaction reduces beta-amyloid generation and ameliorates Alzheimer's disease-related pathogenesis
期刊论文
CELL DISCOVERY, 2015, 卷号: 1
作者:
Cui, Jin
;
Wang, Xiaoyin
;
Li, Xiaohang
;
Wang, Xin
;
Zhang, Chenlu
收藏
  |  
浏览/下载:14/0
  |  
提交时间:2019/01/08
PS1/BACE1 interaction
A beta generation
Alzheimer's disease
Smart Soup, a Traditional Chinese Medicine Formula, Ameliorates Amyloid Pathology and Related Cognitive Deficits
期刊论文
PLOS ONE, 2014, 卷号: 9, 期号: 11
作者:
Hou, Yujun
;
Wang, Ying
;
Zhao, Jian
;
Li, Xiaohang
;
Cui, Jin
收藏
  |  
浏览/下载:15/0
  |  
提交时间:2019/01/08
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