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科研机构
上海药物研究所 [143]
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期刊论文 [143]
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2021 [4]
2020 [12]
2019 [11]
2018 [27]
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Multi-level fingerprinting and cardiomyocyte protection evaluation for comparing polysaccharides from six Panax herbal medicines
期刊论文
CARBOHYDRATE POLYMERS, 2022, 卷号: 277, 页码: 10
作者:
Liu, Jie
;
Wang, Hong-da
;
Yang, Fei-fei
;
Chen, Bo-xue
;
Li, Xue
收藏
  |  
浏览/下载:93/0
  |  
提交时间:2022/01/04
Panax
Polysaccharide
Oligosaccharide spectrum
Untargeted metabolomics
Cardiomyocyte protection
Distal mutation V486M disrupts the catalytic activity of DPP4 by affecting the flap of the propeller domain
期刊论文
ACTA PHARMACOLOGICA SINICA, 2021, 页码: 9
作者:
Li, Teng-teng
;
Peng, Cheng
;
Wang, Ji-qiu
;
Xu, Zhi-jian
;
Su, Ming-bo
收藏
  |  
浏览/下载:42/0
  |  
提交时间:2022/01/18
DPP4
distal mutation
enzymatic activity
molecular dynamics simulation
structure-function mechanism
Small-molecule fluorescence-based probes for interrogating major organ diseases
期刊论文
CHEMICAL SOCIETY REVIEWS, 2021, 页码: 39
作者:
Han, Hai-Hao
;
Tian, He, Jr.
;
Zang, Yi
;
Sedgwick, Adam C.
;
Li, Jia
收藏
  |  
浏览/下载:18/0
  |  
提交时间:2021/08/17
Discovery of 1,5-Dihydro-4H-imidazol-4-one Derivatives as Potent, Selective Antagonists of CXC Chemokine Receptor 2
期刊论文
ACS MEDICINAL CHEMISTRY LETTERS, 2021, 卷号: 12, 期号: 5, 页码: 836-845
作者:
Che, Jinxin
;
Wang, Zhilong
;
Shen, Zheyuan
;
Zhuang, Weihao
;
Ying, Huazhou
收藏
  |  
浏览/下载:60/0
  |  
提交时间:2021/08/17
cancer metastasis
CXCR1
CXCR2
selectivity
antagonist
1,5-dihydro-4H-imidazol-4-one
Modular Chemical Synthesis of Streptogramin and Lankacidin Antibiotics
期刊论文
ACCOUNTS OF CHEMICAL RESEARCH, 2021, 卷号: 54, 期号: 8, 页码: 1891-1908
作者:
Cai, Lingchao
;
Seiple, Ian B.
;
Li, Qi
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  |  
浏览/下载:18/0
  |  
提交时间:2021/06/11
Structure-based drug optimization and biological evaluation of tetrahydroquinolin derivatives as selective and potent CBP bromodomain inhibitors
期刊论文
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2020, 卷号: 30, 期号: 22, 页码: 7
作者:
Bi, Xiaoyang
;
Chen, Yu
;
Sun, Zhongya
;
Lu, Wenchao
;
Xu, Pan
收藏
  |  
浏览/下载:21/0
  |  
提交时间:2021/05/24
Drug design
CBP
Bromodomain
Inhibitor
Acute myeloid leukemia
Nostoc sphaeroids Kutz polysaccharide and powder enrich a core bacterial community on C57BL/6j mice
期刊论文
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES, 2020, 卷号: 162, 页码: 1734-1742
作者:
Li, Meixia
;
Guo, Ciliang
;
Wang, Yeqing
;
Du, Zhenyun
;
Chen, Sheng
收藏
  |  
浏览/下载:18/0
  |  
提交时间:2020/12/24
Nostoc sphaeroids Kutz polysaccharide
Nostoc sphaeroids Kutz powder
16S ribosomal RNA gene sequencing
Core bacterial community
The unprecedented diversity of UGT94-family UDP-glycosyltransferases in Panax plants and their contribution to ginsenoside biosynthesis
期刊论文
SCIENTIFIC REPORTS, 2020, 卷号: 10, 期号: 1, 页码: 11
作者:
Yang, Chengshuai
;
Li, Chaojing
;
Wei, Wei
;
Wei, Yongjun
;
Liu, Qunfang
收藏
  |  
浏览/下载:34/0
  |  
提交时间:2020/12/21
The homogenous polysaccharide SY01-23 purified from leaf of Morus alba L. has bioactivity on human gut Bacteroides ovatus and Bacteroides cellulosilyticus
期刊论文
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES, 2020, 卷号: 158, 页码: 698-707
作者:
Wang, Yeqing
;
Shao, Saicong
;
Guo, Ciliang
;
Zhang, Shihai
;
Li, Meixia
收藏
  |  
浏览/下载:14/0
  |  
提交时间:2020/12/24
Morus alba L.
Polysaccharide
Human gut microbiota
Cross-feeding
Short-chain fatty acids
Cryo-electron microscopy structure of the glucagon receptor with a dual-agonist peptide
期刊论文
JOURNAL OF BIOLOGICAL CHEMISTRY, 2020, 卷号: 295, 期号: 28, 页码: 9313-9325
作者:
Chang, Rulue
;
Zhang, Xin
;
Qiao, Anna
;
Dai, Antao
;
Belousoff, Matthew J.
收藏
  |  
浏览/下载:85/0
  |  
提交时间:2020/12/24
glucagon receptor
glucagon-like peptide-1 receptor
dual agonist
cryo-electron microscopy
single particle analysis
structure-function
structural biology
peptide 15 (P15)
metabolic disorder
G protein?coupled receptor (GPCR)
glucagon
GLP-1 receptor
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