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科研机构
上海药物研究所 [496]
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期刊论文 [488]
学位论文 [4]
会议论文 [3]
项目 [1]
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2022 [1]
2021 [33]
2020 [47]
2019 [41]
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2017 [33]
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Repressing MYC by targeting BET synergizes with selective inhibition of PI3K alpha against B cell lymphoma
期刊论文
CANCER LETTERS, 2022, 卷号: 524, 页码: 206-218
作者:
Chen, Zi-qi
;
Cao, Zhe-rui
;
Wang, Yi
;
Zhang, Xi
;
Xu, Lan
收藏
  |  
浏览/下载:53/0
  |  
提交时间:2021/12/16
CYH33
MYC
P300
BET
B cell lymphoma
PI3K
Discovery of a novel DDRs kinase inhibitor XBLJ-13 for the treatment of idiopathic pulmonary fibrosis
期刊论文
ACTA PHARMACOLOGICA SINICA, 2021, 页码: 11
作者:
Dong, Ying
;
Tang, Bi-xi
;
Wang, Qi
;
Zhou, Li-wei
;
Li, Cong
收藏
  |  
浏览/下载:73/0
  |  
提交时间:2022/01/04
idiopathic pulmonary fibrosis
DDRs
kinase inhibitor
indazole derivatives
XBLJ-13
nintedanib
bleomycin-induced pulmonary fibrosismouse model
A General Set of DNA-Compatible Reactions for Preparing DNA-Tagged Multisubstituted Pyrroles
期刊论文
BIOCONJUGATE CHEMISTRY, 2021, 卷号: 32, 期号: 11, 页码: 2290-2294
作者:
Qi, Jingjing
;
Liu, Sixiu
;
Seydimemet, Mengnisa
;
Wang, Xuan
;
Lu, Xiaojie
收藏
  |  
浏览/下载:16/0
  |  
提交时间:2022/01/04
Development of FABP4/5 inhibitors with potential therapeutic effect on type 2 Diabetes Mellitus
期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2021, 卷号: 224, 页码: 14
作者:
He, Yu-Long
;
Chen, Meng-Ting
;
Wang, Ting
;
Zhang, Ming-Ming
;
Li, Ying-Xia
收藏
  |  
浏览/下载:63/0
  |  
提交时间:2021/11/04
Type 2 diabetes mellitus
Dual FABP4/5 inhibitors
Anti-lipolytic and anti-inflammatory effects
Metabolic stability
Anti-diabetic activities
Oxidized Low-Density Lipoprotein Links Hypercholesterolemia and Bladder Cancer Aggressiveness by Promoting Cancer Stemness
期刊论文
CANCER RESEARCH, 2021, 卷号: 81, 期号: 22, 页码: 5720-5732
作者:
Yang, Lin
;
Sun, Jingya
;
Li, Meiqian
;
Long, Yiming
;
Zhang, Dianzheng
收藏
  |  
浏览/下载:23/0
  |  
提交时间:2022/01/04
Drug target inference by mining transcriptional data using a novel graph convolutional network framework
期刊论文
PROTEIN & CELL, 2021, 页码: 21
作者:
Zhong, Feisheng
;
Wu, Xiaolong
;
Yang, Ruirui
;
Li, Xutong
;
Wang, Dingyan
收藏
  |  
浏览/下载:22/0
  |  
提交时间:2021/12/01
drug target inference
transcriptomics
deep learning
experimental verification
Discovery of Potent and Selective CDK9 Degraders for Targeting Transcription Regulation in Triple-Negative Breast Cancer
期刊论文
JOURNAL OF MEDICINAL CHEMISTRY, 2021, 卷号: 64, 期号: 19, 页码: 14822-14847
作者:
Wei, Dan
;
Wang, Hanlin
;
Zeng, Qinghe
;
Wang, Wenjing
;
Hao, Bingbing
收藏
  |  
浏览/下载:30/0
  |  
提交时间:2021/12/16
Rational Design and Development of Novel CDK9 Inhibitors for the Treatment of Acute Myeloid Leukemia
期刊论文
JOURNAL OF MEDICINAL CHEMISTRY, 2021, 卷号: 64, 期号: 19, 页码: 14647-14663
作者:
Han, Xu
;
Song, Ning
;
Saidahmatov, Abdusaid
;
Wang, Peipei
;
Wang, Yong
收藏
  |  
浏览/下载:17/0
  |  
提交时间:2021/12/16
Crowdsourced identification of multi-target kinase inhibitors for RET- and TAU- based disease: The Multi-Targeting Drug DREAM Challenge
期刊论文
PLOS COMPUTATIONAL BIOLOGY, 2021, 卷号: 17, 期号: 9, 页码: 19
作者:
Xiong, Zhaoping
;
Jeon, Minji
;
Allaway, Robert J.
;
Kang, Jaewoo
;
Park, Donghyeon
收藏
  |  
浏览/下载:22/0
  |  
提交时间:2021/11/04
Restoring perturbed oxylipins with Danqi Tongmai Tablet attenuates acute myocardial infarction
期刊论文
PHYTOMEDICINE, 2021, 卷号: 90, 页码: 12
作者:
Zhi, Haijuan
;
Zhang, Zijia
;
Deng, Yanping
;
Yan, Bingpeng
;
Li, Zhenwei
收藏
  |  
浏览/下载:48/0
  |  
提交时间:2021/11/04
Acute myocardial infarction
Danqi Tongmai tablet
In vivo metabolite
Oxylipin
Arachidonic acid metabolome
Homeostasis
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