A General Set of DNA-Compatible Reactions for Preparing DNA-Tagged Multisubstituted Pyrroles

doi:10.1021/acs.bioconjchem.1c00427

	A General Set of DNA-Compatible Reactions for Preparing DNA-Tagged Multisubstituted Pyrroles
	Qi, Jingjing 1,2; Liu, Sixiu 2,3; Seydimemet, Mengnisa 1,2; Wang, Xuan 2; Lu, Xiaojie 1,2,3
刊名	BIOCONJUGATE CHEMISTRY
	2021-11-17
卷号	32 期号:11 页码:2290-2294
ISSN号	1043-1802
DOI	10.1021/acs.bioconjchem.1c00427
通讯作者	Wang, Xuan(wangxuan2@simm.ac.cn) ; Lu, Xiaojie(xjlu@simm.ac.cn)
英文摘要	DNA-encoded library (DEL) technology provided a powerful screening platform for identifying potential bioactive small molecules with high affinity to biologically interesting targets. Essential to a successful DEL campaign are the drug-like small molecular moieties of DNA-encoded libraries with expanded chemical space. Our laboratory has been working on developing and producing novel DNA-encoded libraries that complement current reported DELs. Herein, we demonstrated a general set of DNA-compatible reactions that enable the preparation of pyrrole-based DNA-encoded libraries in which the DNA tags are linked to the N position of the pyrrole central core. Further diversification could be rapidly incorporated into the pyrrole scaffold by robust iodination and Suzuki coupling reactions.
资助项目	NSFC[21877117] ; NSFC[91953203] ; NSFC[21907103] ; National Science & Technology Major Project Key New Drug Creation and Manufacturing Program, China[2018ZX09711002-005] ; Shanghai Commission of Science and Technology[18431907100]
WOS研究方向	Biochemistry & Molecular Biology ; Chemistry
语种	英语
出版者	AMER CHEMICAL SOC
WOS记录号	WOS:000721347100002
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/298964]
专题	中国科学院上海药物研究所
通讯作者	Wang, Xuan; Lu, Xiaojie
作者单位	1.Nanjing Univ Chinese Med, Sch Chinese Mat Med, Nanjing 210023, Peoples R China 2.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China 3.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
推荐引用方式 GB/T 7714	Qi, Jingjing,Liu, Sixiu,Seydimemet, Mengnisa,et al. A General Set of DNA-Compatible Reactions for Preparing DNA-Tagged Multisubstituted Pyrroles[J]. BIOCONJUGATE CHEMISTRY,2021,32(11):2290-2294.
APA	Qi, Jingjing,Liu, Sixiu,Seydimemet, Mengnisa,Wang, Xuan,&Lu, Xiaojie.(2021).A General Set of DNA-Compatible Reactions for Preparing DNA-Tagged Multisubstituted Pyrroles.BIOCONJUGATE CHEMISTRY,32(11),2290-2294.
MLA	Qi, Jingjing,et al."A General Set of DNA-Compatible Reactions for Preparing DNA-Tagged Multisubstituted Pyrroles".BIOCONJUGATE CHEMISTRY 32.11(2021):2290-2294.