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PARP14 inhibits microglial activation via LPAR5 to promote post-stroke functional recovery 期刊论文
AUTOPHAGY, 2021, 卷号: 17, 期号: 10, 页码: 2905-2922
作者:  Tang, Ying;  Liu, Jinchang;  Wang, Yu;  Yang, Li;  Han, Bing
收藏  |  浏览/下载:45/0  |  提交时间:2022/01/04
Pharmacodynamic, pharmacokinetic, and phase 1a study of bisthianostat, a novel histone deacetylase inhibitor, for the treatment of relapsed or refractory multiple myeloma 期刊论文
ACTA PHARMACOLOGICA SINICA, 2021, 页码: 9
作者:  Zhou, Yu-bo;  Zhang, Yang-ming;  Huang, Hong-hui;  Shen, Li-jing;  Han, Xiao-feng
收藏  |  浏览/下载:92/0  |  提交时间:2021/11/04
Glycogen synthase kinase 3 beta inhibition synergizes with PARP inhibitors through the induction of homologous recombination deficiency in colorectal cancer 期刊论文
CELL DEATH & DISEASE, 2021, 卷号: 12, 期号: 2, 页码: 18
作者:  Zhang, Ning;  Tian, Yu-Nan;  Zhou, Li-Na;  Li, Meng-Zhu;  Chen, Hua-Dong
收藏  |  浏览/下载:20/0  |  提交时间:2021/05/24
TSL-1502, a glucuronide prodrug of a poly (ADP-ribose) polymerase (PARP) inhibitor, exhibits potent anti-tumor activity in preclinical models 期刊论文
AMERICAN JOURNAL OF CANCER RESEARCH, 2021, 卷号: 11, 期号: 4, 页码: 1632-1645
作者:  Wang, Lei;  Zhu, Xi;  Li, Lili;  Li, Lin;  Fu, Li
收藏  |  浏览/下载:74/0  |  提交时间:2021/06/11
Identification of 2-substituted pyrrolo[1,2-b]pyridazine derivatives as new PARP-1 inhibitors 期刊论文
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2021, 卷号: 31, 页码: 4
作者:  Xiang, Hao-Yue;  Chen, Jian-Yang;  Huan, Xia-Juan;  Chen, Yi;  Gao, Zhao-bing
收藏  |  浏览/下载:14/0  |  提交时间:2021/05/24
Optimization of piperidine constructed peptidyl derivatives as proteasome inhibitors 期刊论文
BIOORGANIC & MEDICINAL CHEMISTRY, 2021, 卷号: 29, 页码: 14
作者:  Zhao, Yanmei;  Xu, Lei;  Zhang, Jiankang;  Zhang, Mengmeng;  Lu, Jingyi
收藏  |  浏览/下载:21/0  |  提交时间:2021/05/24
Glycogen synthase kinase 3β inhibition synergizes with PARP inhibitors through the induction of homologous recombination deficiency in colorectal cancer 期刊论文
Cell Death & Disease, 2021, 卷号: 12, 期号: 2, 页码: 1
作者:  Ning Zhang;  Yu-Nan Tian;  Li-Na Zhou;  Meng-Zhu Li;  Hua-Dong Chen
收藏  |  浏览/下载:18/0  |  提交时间:2021/12/01
BRD4 inhibitor nitroxoline enhances the sensitivity of multiple myeloma cells to bortezomib in vitro and in vivo by promoting mitochondrial pathway-mediated cell apoptosis 期刊论文
THERAPEUTIC ADVANCES IN HEMATOLOGY, 2020, 卷号: 11, 页码: 12
作者:  Li, Guang;  Zheng, Yan-Hua;  Xu, Li;  Feng, Juan;  Tang, Hai-Long
收藏  |  浏览/下载:46/0  |  提交时间:2020/12/24
Discovery and biological evaluation of N-(3-(7-((2-methoxy-4-(4-methylpiperazin-1-yl)phenyl)amino)-4-methyl-2-oxo-2H-pyrimido[4,5-d][1,3]oxazin-1(4H)-yl)phenyl)acrylamide as potent Bruton's tyrosine kinase inhibitors 期刊论文
ACTA PHARMACOLOGICA SINICA, 2020, 卷号: 41, 期号: 3, 页码: 415-422
作者:  Lai, Meng-zhen;  Song, Pei-ran;  Dou, Dou;  Diao, Yan-yan;  Tong, Lin-jiang
收藏  |  浏览/下载:34/0  |  提交时间:2020/07/01
Polymerase independent repression of FoxO1 transcription by sequence-specific PARP1 binding to FoxO1 promoter 期刊论文
CELL DEATH & DISEASE, 2020, 卷号: 11, 期号: 1, 页码: 12
作者:  Tian, Yu-Nan;  Chen, Hua-Dong;  Tian, Chang-Qing;  Wang, Ying-Qing;  Miao, Ze-Hong
收藏  |  浏览/下载:10/0  |  提交时间:2020/12/24


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