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科研机构
上海药物研究所 [33]
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期刊论文 [31]
会议论文 [2]
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2020 [1]
2019 [2]
2018 [4]
2017 [1]
2016 [7]
2015 [8]
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Optimized HSP90 mediated fluorescent probes for cancer-specific bioimaging
期刊论文
JOURNAL OF MATERIALS CHEMISTRY B, 2020, 卷号: 8, 期号: 9, 页码: 1878-1896
作者:
Zhu, Shulei
;
Li, Yalei
;
Huang, Yushu
;
Zhang, Minmin
;
Gu, Xiaofan
收藏
  |  
浏览/下载:27/0
  |  
提交时间:2020/07/01
Design, Synthesis and Pharmacological Evaluation of Novel Hsp90N-terminal Inhibitors Without Induction of Heat Shock Response
期刊论文
CHEMISTRYOPEN, 2019, 卷号: 8, 期号: 3, 页码: 344-353
作者:
Liu, Peng
;
Chen, Xiangling
;
Zhu, Jianming
;
Li, Bo
;
Chen, Zhaoqiang
收藏
  |  
浏览/下载:33/0
  |  
提交时间:2020/07/01
autophagy
Hsp72
Hsp90 inhibitor
triazines
antitumor activity
Inhibition of HSP90 beta Improves Lipid Disorders by Promoting Mature SREBPs Degradation via the Ubiquitin-proteasome System
期刊论文
THERANOSTICS, 2019, 卷号: 9, 期号: 20, 页码: 5769-5783
作者:
Zheng, Zu-Guo
;
Zhang, Xin
;
Liu, Xiao-Xiao
;
Jin, Xiu-Xiu
;
Dai, Lunzhi
收藏
  |  
浏览/下载:17/0
  |  
提交时间:2020/07/01
HSP90 beta
lipid metabolism
corylin
SREBPs
proteasomal degradation
Discovery of FS36 as a Novel Human Hsp90 Inhibitor
期刊论文
PROGRESS IN BIOCHEMISTRY AND BIOPHYSICS, 2018, 卷号: 45, 期号: 7, 页码: 736-744
作者:
Li Gen
;
Lu Kai-Kai
;
Li Jian
;
Yin Xiu-Shan
;
Zhao Dong
收藏
  |  
浏览/下载:21/0
  |  
提交时间:2019/01/08
heat shock protein 90
antitumor drugs
inhibitor
X-ray diffraction
complex crystal structure
Design, synthesis and pharmacological evaluation of ALK and Hsp90 dual inhibitors bearing resorcinol and 2,4-diaminopyrimidine motifs
期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2018, 卷号: 152, 页码: 76-86
作者:
Geng, Kaijun
;
Liu, Hongchun
;
Song, Zilan
;
Zhang, Chi
;
Zhang, Minmin
收藏
  |  
浏览/下载:177/0
  |  
提交时间:2019/01/08
Heat shock protein 90 (Hsp90)
Tyrosine kinase ALK
Dual inhibitor
Drug resistance
Antiproliferative activity
Identification and therapeutic intervention of coactivated anaplastic lymphoma kinase, fibroblast growth factor receptor 2, and ephrin type-A receptor 5 kinases in hepatocellular carcinoma
期刊论文
Hepatology (Baltimore, Md.), 2018
作者:
Wang, Xin
;
Zhang, Minmin
;
Ping, Fangfang
;
Liu, Hongchun
;
Sun, Jingya
收藏
  |  
浏览/下载:56/0
  |  
提交时间:2019/01/08
Dynamics revelation of conformational changes and binding modes of heat shock protein 90 induced by inhibitor associations
期刊论文
RSC ADVANCES, 2018, 卷号: 8, 期号: 45, 页码: 25456-25467
作者:
Chen, Jianzhong
;
Wang, Jinan
;
Lai, Fengbo
;
Wang, Wei
;
Pang, Laixue
收藏
  |  
浏览/下载:26/0
  |  
提交时间:2019/01/08
Design, synthesis and pharmacological evaluation of 4,5-diarylisoxazols bearing amino acid residues within the 3-amido motif as potent heat shock protein 90 (Hsp90) inhibitors
期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2017, 卷号: 125, 页码: 315-326
作者:
Zhang, Chi
;
Wang, Xin
;
Liu, Hongchun
;
Zhang, Minmin
;
Geng, Meiyu
收藏
  |  
浏览/下载:51/0
  |  
提交时间:2019/01/08
Diarylisoxazole
Resorcinol
Amino acid
Hsp90 inhibitor
Antiproliferative effect
Targeting Hsp90 with FS-108 circumvents gefitinib resistance in EGFR mutant non-small cell lung cancer cells
期刊论文
ACTA PHARMACOLOGICA SINICA, 2016, 卷号: 37, 期号: 12, 页码: 1587-1596
作者:
Wang, Yue-qin
;
Shen, Ai-jun
;
Sun, Jing-ya
;
Wang, Xin
;
Liu, Hong-chun
收藏
  |  
浏览/下载:31/0
  |  
提交时间:2019/01/08
non-small cell lung cancer
gefitinib resistance
Hsp90
Regulation of Ubiquitin-like with Plant Homeodomain and RING Finger Domain 1 (UHRF1) Protein Stability by Heat Shock Protein 90 Chaperone Machinery
期刊论文
JOURNAL OF BIOLOGICAL CHEMISTRY, 2016, 卷号: 291, 期号: 38, 页码: 20125-20135
作者:
Ding, Guangjin
;
Chen, Peilin
;
Zhang, Hui
;
Huang, Xiaojie
;
Zang, Yi
收藏
  |  
浏览/下载:15/0
  |  
提交时间:2019/01/08
70-kilodalton heat shock protein (HSP70)
cancer therapy
DNA methylation
protein degradation
ubiquitin
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