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科研机构
上海药物研究所 [139]
内容类型
期刊论文 [138]
会议论文 [1]
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2021 [10]
2020 [10]
2019 [9]
2018 [8]
2017 [9]
2016 [12]
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共139条,第1-10条
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New monoamine antidepressant, hypidone hydrochloride (YL-0919), enhances the excitability of medial prefrontal cortex in mice via a neural disinhibition mechanism
期刊论文
ACTA PHARMACOLOGICA SINICA, 2021, 页码: 11
作者:
Zhang, Yong-Mei
;
Ye, Lu-Yu
;
Li, Tian-Yu
;
Guo, Fan
;
Guo, Fei
收藏
  |  
浏览/下载:23/0
  |  
提交时间:2022/01/04
YL-0919
medial prefrontal cortex
GABAergic neurons
5-HT1A receptor
GAD67-GFP transgenic mice
disinhibition
fluoxetine
electrophysiological recording
Dezocine as a potent analgesic: overview of its pharmacological characterization
期刊论文
ACTA PHARMACOLOGICA SINICA, 2021, 页码: 12
作者:
Ye, Rong-Rong
;
Jiang, Shuang
;
Xu, Xu
;
Lu, Yan
;
Wang, Yu-Jun
收藏
  |  
浏览/下载:30/0
  |  
提交时间:2021/12/16
dezocine
opioid receptors
norepinephrine
serotonin transporter
postoperative pain
anesthesia
Ketamine activated glutamatergic neurotransmission by GABAergic disinhibition in the medial prefrontal cortex
期刊论文
NEUROPHARMACOLOGY, 2021, 卷号: 194, 页码: 10
作者:
Zhang, Bing
;
Yang, Xili
;
Ye, Luyu
;
Liu, Rui
;
Ye, Binglu
收藏
  |  
浏览/下载:20/0
  |  
提交时间:2021/08/17
Inhibition of PDE4 by apremilast attenuates skin fibrosis through directly suppressing activation of M1 and T cells
期刊论文
ACTA PHARMACOLOGICA SINICA, 2021, 页码: 11
作者:
Lu, Qiu-kai
;
Fan, Chen
;
Xiang, Cai-gui
;
Wu, Bing
;
Lu, Hui-min
收藏
  |  
浏览/下载:58/0
  |  
提交时间:2021/06/11
PDE4
apremilast
skin fibrosis
macrophages
Cyclin-dependent kinase inhibitor roscovitine attenuates liver inflammation and fibrosis by influencing initiating steps of liver injury
期刊论文
CLINICAL SCIENCE, 2021, 卷号: 135, 期号: 7, 页码: 925-941
作者:
Liu, Yanjun
;
Li, Jiacheng
;
Liao, Liping
;
Huang, Heming
;
Fan, Shijie
收藏
  |  
浏览/下载:21/0
  |  
提交时间:2021/08/17
A novel GPR120-selective agonist promotes insulin secretion and improves chronic inflammation
期刊论文
LIFE SCIENCES, 2021, 卷号: 269, 页码: 8
作者:
Yang, Liu
;
Lei, Xian-Tao
;
Huang, Qi
;
Wang, Ting
;
Sun, Hong-Bin
收藏
  |  
浏览/下载:23/0
  |  
提交时间:2021/05/24
GPR120 agonist
Insulin secretion
Anti-inflammation
Insulin resistance
Type 2 diabetes mellitus
SL010110, a lead compound, inhibits gluconeogenesis via SIRT2-p300-mediated PEPCK1 degradation and improves glucose homeostasis in diabetic mice
期刊论文
ACTA PHARMACOLOGICA SINICA, 2021, 页码: 13
作者:
Ren, Yu-ran
;
Ye, Yang-liang
;
Feng, Ying
;
Xu, Ti-fei
;
Shen, Yu
收藏
  |  
浏览/下载:22/0
  |  
提交时间:2021/05/24
SL010110
gluconeogenesis
primary mouse hepatocytes
PEPCK1
acetylation
degradation
Design, synthesis, and biological evaluation of tetrahydroisoquinolines derivatives as novel, selective PDE4 inhibitors for antipsoriasis treatment
期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2021, 卷号: 211, 页码: 20
作者:
Zhang, Rui
;
Li, Heng
;
Zhang, Xianglei
;
Li, Jian
;
Su, Haixia
收藏
  |  
浏览/下载:23/0
  |  
提交时间:2021/05/24
PDE4 inhibitors
Tetrahydroisoquinoline
Antipsoriasis
Chronic administration of synthetic cannabidiol induces antidepressant effects involving modulation of serotonin and noradrenaline levels in the hippocampus
期刊论文
NEUROSCIENCE LETTERS, 2021, 卷号: 744, 页码: 7
作者:
Abame, Melkamu Alemu
;
He, Yang
;
Wu, Song
;
Xie, Zhifei
;
Zhang, Jian
收藏
  |  
浏览/下载:24/0
  |  
提交时间:2021/05/24
Synthetic cannabidiol
Depression
Serotonin
Noradrenaline
Nuclear factor kappa B
Sleeve gastrectomy ameliorated high-fat diet (HFD)-induced non-alcoholic fatty liver disease and upregulated the nicotinamide adenine dinucleotide +/ Sirtuin-1 pathway in mice
期刊论文
ASIAN JOURNAL OF SURGERY, 2021, 卷号: 44, 期号: 1, 页码: 213-220
作者:
Hua, Rong
;
Wang, Guan-Zhen
;
Shen, Qi-Wei
;
Yang, Ye-Ping
;
Wang, Meng
收藏
  |  
浏览/下载:23/0
  |  
提交时间:2021/05/24
NAD
NAFLD
NRK1
SIRT1
Sleeve gastrectomy
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