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科研机构
上海药物研究所 [31]
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期刊论文 [31]
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2021 [1]
2018 [2]
2017 [1]
2016 [1]
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Chemistry [2]
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A novel GPR120-selective agonist promotes insulin secretion and improves chronic inflammation
期刊论文
LIFE SCIENCES, 2021, 卷号: 269, 页码: 8
作者:
Yang, Liu
;
Lei, Xian-Tao
;
Huang, Qi
;
Wang, Ting
;
Sun, Hong-Bin
收藏
  |  
浏览/下载:23/0
  |  
提交时间:2021/05/24
GPR120 agonist
Insulin secretion
Anti-inflammation
Insulin resistance
Type 2 diabetes mellitus
Design, Synthesis, and SAR Studies of Heteroarylpyrimidines and Heteroaryltriazines as CB2R Ligands
期刊论文
CHEMMEDCHEM, 2018, 卷号: 13, 期号: 22, 页码: 2455-2463
作者:
Qian, Hai-Yan
;
Wang, Zhi-Long
;
Chen, Li-Li
;
Pan, You-Lu
;
Xie, Xiao-Yu
收藏
  |  
浏览/下载:90/0
  |  
提交时间:2019/01/08
cannabinoids
CB1R
CB2R
heteroaryl pyrimidines
heteroaryl triazines
ligands
Two distinct domains of the glucagon-like peptide-1 receptor control peptide-mediated biased agonism
期刊论文
JOURNAL OF BIOLOGICAL CHEMISTRY, 2018, 卷号: 293, 期号: 24, 页码: 9370-9387
作者:
Lei, Saifei
;
Clydesdale, Lachlan
;
Dai, Antao
;
Cai, Xiaoqing
;
Feng, Yang
收藏
  |  
浏览/下载:51/0
  |  
提交时间:2019/01/08
G protein-coupled receptor (GPCR)
glucagon
receptor structure-function
cell signaling
site-directed mutagenesis
biased agonism
GLP-1 receptor
glucagon-like peptide-1
class B peptide hormone
ERK kinase
arrestin
transmembrane domain
Developing pyridazine-3-carboxamides to be CB2 agonists: The design, synthesis, structure-activity relationships and docking studies
期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2017, 卷号: 137, 页码: 598-611
作者:
Qian, Hai-Yan
;
Wang, Zhi-Long
;
Xie, Xiao-Yu
;
Pan, You-Lu
;
Li, Gang-Jian
收藏
  |  
浏览/下载:24/0
  |  
提交时间:2019/01/08
Pyridazine-3-carboxamides
CB2 agonist
Structure-activity relationships
Molecular docking
logP
Discovery and Characterization of a Novel Small-Molecule Agonist for Medium-Chain Free Fatty Acid Receptor G Protein-Coupled Receptor 84
期刊论文
JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, 2016, 卷号: 357, 期号: 2, 页码: 337-344
作者:
Zhang, Qing
;
Yang, Hui
;
Li, Jing
;
Xie, Xin
收藏
  |  
浏览/下载:25/0
  |  
提交时间:2019/01/08
Yhhu4488, a novel GPR40 agonist, promotes GLP-1 secretion and exerts anti-diabetic effect in rodent models
期刊论文
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2015, 卷号: 466, 期号: 4, 页码: 740-747
作者:
Guo, Dan-yang
;
Li, De-wen
;
Ning, Meng-meng
;
Dang, Xiang-yu
;
Zhang, Li-na
收藏
  |  
浏览/下载:15/0
  |  
提交时间:2019/01/08
Yhhu4488
GPR40
Type 2 diabetes mellitus
Glucagon-like peptide-1
Insulin
High-throughput screening of antagonists for the orphan G-protein coupled receptor GPR139
期刊论文
ACTA PHARMACOLOGICA SINICA, 2015, 卷号: 36, 期号: 7, 页码: 874-878
作者:
Wang, Jia
;
Zhu, Lin-yun
;
Liu, Qing
;
Hentzer, Morten
;
Smith, Garrick Paul
收藏
  |  
浏览/下载:13/0
  |  
提交时间:2019/01/08
orphan G-protein coupled receptor
GPR139
high-throughput screening
calcium mobilization assay
antagonist
Establishment and Application of a High-throughput-screening Model for Medium-chain Fatty Acid-sensing Receptor GPR84
期刊论文
PROGRESS IN BIOCHEMISTRY AND BIOPHYSICS, 2015, 卷号: 42, 期号: 4, 页码: 337-347
作者:
Zhang Qing
;
Yang Hui
;
Li Jia
;
Xie Xin
;
Li Jing
收藏
  |  
浏览/下载:13/0
  |  
提交时间:2019/01/08
GPR84
stably expressing
calcium mobilization assay
high-throughput screening
Design, syntheses, structure-activity relationships and docking studies of coumarin derivatives as novel selective ligands for the CB2 receptor
期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2015, 卷号: 93, 页码: 16-32
作者:
Han, Shuang
;
Zhang, Fei-Fei
;
Qian, Hai-Yan
;
Chen, Li-Li
;
Pu, Jian-Bin
收藏
  |  
浏览/下载:10/0
  |  
提交时间:2019/01/08
GPCR
Cannabinoid CB2 receptor
Structure-activity relationship
Coumarin
Design, synthesis, and biological evaluation of novel 2-methylpiperazine derivatives as potent CCR5 antagonists
期刊论文
BIOORGANIC & MEDICINAL CHEMISTRY, 2015, 卷号: 23, 期号: 5, 页码: 1157-1168
作者:
Hu, Suwen
;
Wang, Zhilong
;
Hou, Tingjun
;
Ma, Xiaodong
;
Li, Jing
收藏
  |  
浏览/下载:19/0
  |  
提交时间:2019/01/08
CCR5 antagonist
Anti-HIV-1 agent
2-Methylpiperazine derivatives
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