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浏览/检索结果: 共9条，第1-9条 帮助 限定条件 专题：上海药物研究所    第一署名单位    第一作者单位    通讯作者单位     已选(0)清除 条数/页：5101520253035404550556065707580859095100   排序方式：请选择作者升序作者降序题名升序题名降序发表日期升序发表日期降序提交时间升序提交时间降序 A novel tricyclic BTK inhibitor suppresses B cell responses and osteoclastic bone erosion in rheumatoid arthritis 期刊论文 ACTA PHARMACOLOGICA SINICA, 2021, 页码: 12 作者:  Liu, Yu-ting;  Ding, Hui-hua;  Lin, Ze-min;  Wang, Que;  Chen, Li 收藏  |  浏览/下载：24/0  |  提交时间：2021/05/24 rheumatoid arthritis  BTK inhibitors  B cells  macrophages  RANKL  osteoclastogenesis   Design and synthesis of Imidazo[1,2-b]pyridazine IRAK4 inhibitors for the treatment of mutant MYD88 L265P diffuse large B-cell lymphoma 期刊论文 EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2020, 卷号: 190, 页码: 14 作者:  Chen, Yun;  Bai, Gang;  Ning, Yi;  Cai, Shi;  Zhang, Tao 收藏  |  浏览/下载：23/0  |  提交时间：2020/07/01 lnterleukin-1 receptor associated kinase 4  Imidazol1,2-6]pyridazine  Diffuse large B-cell lymphoma  Drug design  Antitumor agents   Discovery and biological evaluation of N-(3-(7-((2-methoxy-4-(4-methylpiperazin-1-yl)phenyl)amino)-4-methyl-2-oxo-2H-pyrimido[4,5-d][1,3]oxazin-1(4H)-yl)phenyl)acrylamide as potent Bruton's tyrosine kinase inhibitors 期刊论文 ACTA PHARMACOLOGICA SINICA, 2020, 卷号: 41, 期号: 3, 页码: 415-422 作者:  Lai, Meng-zhen;  Song, Pei-ran;  Dou, Dou;  Diao, Yan-yan;  Tong, Lin-jiang 收藏  |  浏览/下载：34/0  |  提交时间：2020/07/01 B cell receptor  Bruton's tyrosine kinase  ibrutinib  small-molecule inhibitor  B cell malignancies   Discovery and Biological evaluation of pyrimido[4,5-d] pyrimidine-2,4(1H, 3H)-dione derivatives as potent Bruton's tyrosine kinase inhibitors 期刊论文 BIOORGANIC & MEDICINAL CHEMISTRY, 2019, 卷号: 27, 期号: 15, 页码: 3390-3395 作者:  Diao, Yanyan;  Fang, Xiaoyu;  Song, Peiran;  Lai, Mengzhen;  Tong, Linjiang 收藏  |  浏览/下载：23/0  |  提交时间：2020/07/01 Bruton's tyrosine kinase  B-cell malignancies  Potent inhibitors  Structure-activity relationship  Cellular activities   Molecular modelling studies on cinnoline-based BTK inhibitors using docking and structure-based 3D-QSAR 期刊论文 SAR AND QSAR IN ENVIRONMENTAL RESEARCH, 2018, 卷号: 29, 期号: 11, 页码: 847-873 作者:  Li, R.;  Du, Y.;  Shen, J. 收藏  |  浏览/下载：36/0  |  提交时间：2019/01/08 BTK inhibitors  B-cell malignancies  molecule docking  3D-QSAR  CoMFA  CoMSIA   Discovery of 4,7-Diamino-5-(4-phenoxyphenyl)-6-methylene-pyrinnido[5,4-b]pyrrolizines as Novel Bruton's Tyrosine Kinase Inhibitors 期刊论文 JOURNAL OF MEDICINAL CHEMISTRY, 2018, 卷号: 61, 期号: 10, 页码: 4608-4627 作者:  Xue, Yu;  Song, Peiran;  Song, Zilan;  Wang, Aoli;  Tong, Linjiang 收藏  |  浏览/下载：36/0  |  提交时间：2019/01/08 Molecular Modeling Studies on Carbazole Carboxamide Based BTK Inhibitors Using Docking and Structure-Based 3D-QSAR 期刊论文 INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2018, 卷号: 19, 期号: 4 作者:  Li, Rui;  Du, Yongli;  Gao, Zhipei;  Shen, Jingkang 收藏  |  浏览/下载：16/0  |  提交时间：2019/01/08 rheumatoid arthritis (RA)  Broton's tyrosine kinase (BTK)  carbazole carboxamide derivatives  3D-QSAR  comparative molecular field analysis (CoMFA)  comparative molecular similarity indices analysis (CoMSIA)   Discovery and biological evaluation of N5-substituted 6,7-dioxo-6,7-dihydropteridine derivatives as potent Bruton's tyrosine kinase inhibitors 期刊论文 MEDCHEMCOMM, 2018, 卷号: 9, 期号: 4, 页码: 697-704 作者:  Chen, Haiyang;  Song, Peiran;  Diao, Yanyan;  Hao, Yongjia;  Dou, Dou 收藏  |  浏览/下载：29/0  |  提交时间：2019/01/08 Discovery of new BTK inhibitors with B cell suppression activity bearing a 4,6-substituted thieno[3,2-d] pyrimidine scaffold 期刊论文 RSC ADVANCES, 2017, 卷号: 7, 期号: 42, 页码: 26060-26069 作者:  Zhang, Qiumeng;  Zhang, Luyao;  Yu, Jie;  Li, Heng;  He, Shijun 收藏  |  浏览/下载：14/0  |  提交时间：2019/01/08