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科研机构
上海药物研究所 [112]
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期刊论文 [112]
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2021 [6]
2020 [4]
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Synthesis and biological evaluation of 2,5-diaryl-1,3,4-oxadiazole derivatives as novel Src homology 2 domain-containing protein tyrosine phosphatase 2 (SHP2) inhibitors
期刊论文
BIOORGANIC CHEMISTRY, 2021, 卷号: 116, 页码: 13
作者:
Meng, Xiang-Dong
;
Gao, Li-Xin
;
Wang, Zhi-Jia
;
Feng, Bo
;
Zhang, Chun
收藏
  |  
浏览/下载:30/0
  |  
提交时间:2021/12/01
2,5-diphenyl-1,3,4-oxadiazole derivatives
SHP2
Inhibitors
Structure-activity relationships (SAR)
Synthesis and Protein Tyrosine Phosphatase 1B (PTP1B) Inhibitory Activity Evaluation of Novel N-Acylhydrazone Derivatives Containing Carbazole and Aromatic Ring/Aromatic Fused Heterocycle
期刊论文
CHINESE JOURNAL OF ORGANIC CHEMISTRY, 2021, 卷号: 41, 期号: 9, 页码: 3593-3607
作者:
Li Yingjun
;
Lin Ledi
;
Liu Jihong
;
Gao Lixin
;
Sheng Li
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  |  
浏览/下载:18/0
  |  
提交时间:2021/12/01
PTP1B inhibitor
carbazole
N-actylhydrazone
synthesis
molecular docking
Rearranged Diels-Alder Adducts and Prenylated Flavonoids as Potential PTP1B Inhibitors from Morus nigra
期刊论文
JOURNAL OF NATURAL PRODUCTS, 2021, 卷号: 84, 期号: 8, 页码: 2303-2311
作者:
Qu, Ke-Jun
;
Wang, Bin
;
Jiang, Chang-Sheng
;
Xie, Bao-Gang
;
Liu, Ai-Hong
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  |  
浏览/下载:41/0
  |  
提交时间:2021/11/04
Synthesis and Protein Tyrosine Phosphatase 1B (PTP1B) Inhibitory Activity Evaluation of Novel Arylaminoacetylhydrazone Derivatives Containing Carbazole Moiety
期刊论文
CHINESE JOURNAL OF ORGANIC CHEMISTRY, 2021, 卷号: 41, 期号: 8, 页码: 3157-3170
作者:
Li Yingjun
;
Lin Ledi
;
Jin Kun
;
Gao Lixin
;
Sheng Li
收藏
  |  
浏览/下载:19/0
  |  
提交时间:2021/11/04
protein tyrosine phosphatase 1B (PTP1B) inhibitor
carbazole
arylaminoacetylhydrazone
synthesis
molecular docking
The Two Formyl Peptide Receptors Differently Regulate GPR84-Mediated Neutrophil NADPH Oxidase Activity
期刊论文
JOURNAL OF INNATE IMMUNITY, 2021, 页码: 15
作者:
Martensson, Jonas
;
Sundqvist, Martina
;
Manandhar, Asmita
;
Leremias, Loukas
;
Zhang, Linjie
收藏
  |  
浏览/下载:41/0
  |  
提交时间:2021/05/24
Neutrophils
G protein-coupled receptors
Cross-talk
Nicotine adenine dinucleotide phosphate oxidase
SL010110, a lead compound, inhibits gluconeogenesis via SIRT2-p300-mediated PEPCK1 degradation and improves glucose homeostasis in diabetic mice
期刊论文
ACTA PHARMACOLOGICA SINICA, 2021, 页码: 13
作者:
Ren, Yu-ran
;
Ye, Yang-liang
;
Feng, Ying
;
Xu, Ti-fei
;
Shen, Yu
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  |  
浏览/下载:22/0
  |  
提交时间:2021/05/24
SL010110
gluconeogenesis
primary mouse hepatocytes
PEPCK1
acetylation
degradation
Synthesis and Protein Tyrosine Phosphatase 1B (PTP1B) Inhibitory Activity Evaluation of Novel Carbazole-Based Carbohydrazone Derivatives
期刊论文
CHINESE JOURNAL OF ORGANIC CHEMISTRY, 2020, 卷号: 40, 期号: 2, 页码: 478-488
作者:
Li, Yingjun
;
Liu, Xuejie
;
Liu, Jihong
;
Gao, Lixin
;
Jin, Kun
收藏
  |  
浏览/下载:44/0
  |  
提交时间:2020/07/01
carbohydrazone
carbazole
synthesis
PTP1B inhibitor
molecular docking
DFT calculations
Alleviation of Synovial Inflammation of Juanbi-Tang on Collagen-Induced Arthritis and TNF-Tg Mice Model
期刊论文
FRONTIERS IN PHARMACOLOGY, 2020, 卷号: 11, 页码: 17
作者:
Wang, Tengteng
;
Jia, Qingyun
;
Chen, Tao
;
Yin, Hao
;
Tian, Xiaoting
收藏
  |  
浏览/下载:31/0
  |  
提交时间:2020/07/01
Juanbi-Tang
rheumatoid arthritis
collagen-induced arthritis
synoviocyte
tumor necrosis factor
Phytochemical and biological studies on rare and endangered plants endemic to China. Part XIV. Structurally diverse terpenoids from the twigs and needles of the endangered plant Picea brachytyla
期刊论文
PHYTOCHEMISTRY, 2020, 卷号: 169, 页码: 11
作者:
Jiang, Wei
;
Xiong, Juan
;
Zang, Yi
;
Li, Junmin
;
Osman, Ezzat E. A.
收藏
  |  
浏览/下载:83/0
  |  
提交时间:2020/07/01
Picea brachytyla (Franch.) E.Pritz.
Pinaceae
Endangered plant
Terpenoids
Brachytylins
ATP citrate lyase (ACL)
SHP2 tyrosine phosphatase
3,6-二取代三唑并噻二唑衍生物的合成及其对细胞分裂周期25B磷酸酶和蛋白酪氨酸磷酸酶1B抑制活性评价
期刊论文
应用化学, 2020, 卷号: 37, 期号: 9, 页码: 994
作者:
李英俊
;
杨鸿境
;
曹欣
;
高立信
;
靳焜
收藏
  |  
浏览/下载:31/0
  |  
提交时间:2020/12/24
triazolothiadiazole
benzimidazole
aryloxyacetic acid
cell division cycle 25B phosphatase inhibitor
protein tyrosine phosphatase 1B inhibitor
三唑并噻二唑
苯并咪唑
芳氧乙酸
细胞分裂周期25B磷酸酶抑制剂
蛋白酪氨酸磷酸酶1B抑制剂
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