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科研机构
上海药物研究所 [73]
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期刊论文 [73]
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2020 [2]
2018 [7]
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DW14006 as a direct AMPK alpha 1 activator improves pathology of AD model mice by regulating microglial phagocytosis and neuroinflammation
期刊论文
BRAIN BEHAVIOR AND IMMUNITY, 2020, 卷号: 90, 页码: 55-69
作者:
Lv, Jianlu
;
Wang, Wei
;
Zhu, Xialin
;
Xu, Xiaoju
;
Yan, Qiuying
收藏
  |  
浏览/下载:29/0
  |  
提交时间:2020/12/21
Alzheimer'sdisease
Microglia
AMPK alpha 1
DW14006
Phagocytosis
Neuro-inflammation
Development of Bisindole-Substituted Aminopyrazoles as Novel GSK-3 beta Inhibitors with Suppressive Effects against Microglial Inflammation and Oxidative Neurotoxicity
期刊论文
ACS CHEMICAL NEUROSCIENCE, 2020, 卷号: 11, 期号: 20, 页码: 3398-3408
作者:
Liu, Jian-Guo
;
Zhao, Danfeng
;
Gong, Qi
;
Bao, Fengxia
;
Chen, Wen-Wen
收藏
  |  
浏览/下载:16/0
  |  
提交时间:2021/05/24
Glycogen synthase kinase-3
bisindole-substituted aminopyrazoles
Alzheimer's disease
oxidative neurotoxicity
microglial inflammation
Nitazoxanide, an anti-parasitic drug, efficiently ameliorates learning and memory impairments in AD model mice
期刊论文
ACTA PHARMACOLOGICA SINICA, 2019, 卷号: 40, 期号: 10, 页码: 1279-1291
作者:
Fan, Lei
;
Qiu, Xiao-xia
;
Zhu, Zhi-yuan
;
Lv, Jian-lu
;
Lu, Jian
收藏
  |  
浏览/下载:19/0
  |  
提交时间:2020/07/01
Alzheimer's disease
nitazoxanide
autophagy
inflammation
APP/PS1 transgenic mice
Fluorescent Imaging of beta-Amyloid Using BODIPY Based Near-Infrared Off-On Fluorescent Probe
期刊论文
BIOCONJUGATE CHEMISTRY, 2018, 卷号: 29, 期号: 10, 页码: 3459-3466
作者:
Ren, Wenming
;
Zhang, Jingjing
;
Peng, Cheng
;
Xiang, Huaijiang
;
Chen, Jingjing
收藏
  |  
浏览/下载:34/0
  |  
提交时间:2019/01/08
N-Phenylquinazolin-2-amine Yhhu4952 as a novel promotor for oligodendrocyte differentiation and myelination
期刊论文
SCIENTIFIC REPORTS, 2018, 卷号: 8
作者:
Yu, Xueli
;
Cheng, Gang
;
Zhang, Lei
;
Zhang, Yu
;
Wang, Qing
收藏
  |  
浏览/下载:85/0
  |  
提交时间:2019/01/08
Design, synthesis and evaluation of vilazodone-tacrine hybrids as multitarget-directed ligands against depression with cognitive impairment
期刊论文
BIOORGANIC & MEDICINAL CHEMISTRY, 2018, 卷号: 26, 期号: 12, 页码: 3117-3125
作者:
Liu, Wenwen
;
Wang, Huan
;
Li, Xiaokang
;
Xu, Yixiang
;
Zhang, Jian
收藏
  |  
浏览/下载:39/0
  |  
提交时间:2019/01/08
Depression
Cognitive impairment
Multitarget-directed ligand
5-HT1A agonist
5-HT reuptake inhibition
ChE inhibition
Novel Tadalafil Derivatives Ameliorates Scopolamine-Induced Cognitive Impairment in Mice via Inhibition of Acetyicholinesterase (AChE) and Phosphodiesterase 5 (PDE5)
期刊论文
ACS CHEMICAL NEUROSCIENCE, 2018, 卷号: 9, 期号: 7, 页码: 1625-1636
作者:
Ni, Wei
;
Wang, Huan
;
Li, Xiaokang
;
Zheng, Xinyu
;
Wang, Manjiong
收藏
  |  
浏览/下载:43/0
  |  
提交时间:2019/01/08
Multifunctional agents
AChE inhibitors
PDE5 inhibitors
Alzheimer's disease
Humanin decreases mitochondrial membrane permeability by inhibiting the membrane association and oligomerization of Bax and Bid proteins
期刊论文
ACTA PHARMACOLOGICA SINICA, 2018, 卷号: 39, 期号: 6, 页码: 1012-1021
作者:
Ma, Ze-wei
;
Liu, Dong-xiang
收藏
  |  
浏览/下载:16/0
  |  
提交时间:2019/01/08
Alzheimer's disease
humanin
Bcl-2 family
mitochondrial outer membrane
single-molecule fluorescence
Iron dysregulates APP processing accompanying with sAPP alpha cellular retention and beta-secretase inhibition in rat cortical neurons
期刊论文
ACTA PHARMACOLOGICA SINICA, 2018, 卷号: 39, 期号: 2, 页码: 177-183
作者:
Chen, Yu-ting
;
Chen, Wu-yan
;
Huang, Xiao-tian
;
Xu, Ye-chun
;
Zhang, Hai-yan
收藏
  |  
浏览/下载:33/0
  |  
提交时间:2019/01/08
iron
neurons
amyloid precursor protein
sAPP alpha
beta-amyloid
beta-secretase
Alzheimer's disease
Characterization of a pectin from Lonicera japonica Thunb. and its inhibition effect on A beta(42) aggregation and promotion of neuritogenesis
期刊论文
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES, 2018, 卷号: 107, 页码: 112-120
作者:
Liu, Qin
;
Fang, Jianping
;
Wang, Peipei
;
Du, Zhenyun
;
Li, Yanling
收藏
  |  
浏览/下载:28/0
  |  
提交时间:2019/01/08
Rhamnogalacturonan I (RG-I) pectic polysaccharide
Lonicera japonica Thunb.
A beta(42) aggregation
Neuritogenesis
Alzheimer's disease
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