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浏览/检索结果: 共17条，第1-10条 帮助 限定条件 发表日期：2021     已选(0)清除 条数/页：5101520253035404550556065707580859095100   排序方式：请选择作者升序作者降序题名升序题名降序发表日期升序发表日期降序提交时间升序提交时间降序 An overview of kinase downregulators and recent advances in discovery approaches 期刊论文 SIGNAL TRANSDUCTION AND TARGETED THERAPY, 2021, 卷号: 6 作者:  Wang, Beilei;  Wu, Hong;  Hu, Chen;  Wang, Haizhen;  Liu, Jing 收藏  |  浏览/下载：39/0  |  提交时间：2022/01/25 Potent and Selective RIPK1 Inhibitors Targeting Dual-Pockets for the Treatment of Systemic Inflammatory Response Syndrome and Sepsis 期刊论文 ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2021, 页码: 6 作者:  Yang, Xiangbo;  Lu, Huimin;  Xie, Hang;  Zhang, Binbin;  Nie, Tianqing 收藏  |  浏览/下载：25/0  |  提交时间：2022/01/18 Binding studies  Drug discovery  Necroptosis  RIPK1 inhibitors  Sepsis   Dynamics of Post-Translational Modification Inspires Drug Design in the Kinase Family 期刊论文 JOURNAL OF MEDICINAL CHEMISTRY, 2021, 卷号: 64, 期号: 20, 页码: 15111-15125 作者:  Zhang, Huimin;  He, Jixiao;  Hu, Guang;  Zhu, Fei;  Jiang, Hao 收藏  |  浏览/下载：36/0  |  提交时间：2022/01/04 DRAK2 aggravates nonalcoholic fatty liver disease progression through SRSF6-associated RNA alternative splicing 期刊论文 CELL METABOLISM, 2021, 卷号: 33, 期号: 10, 页码: 2004-+ 作者:  Li, Yufeng;  Xu, Junyu;  Lu, Yuting;  Bian, Hua;  Yang, Lin 收藏  |  浏览/下载：23/0  |  提交时间：2022/01/18 Imatinib protects against human beta-cell death via inhibition of mitochondrial respiration and activation of AMPK 期刊论文 CLINICAL SCIENCE, 2021, 卷号: 135, 期号: 19, 页码: 2243-2263 作者:  Elksnis, Andris;  Schiffer, Tomas A.;  Palm, Fredrik;  Wang, Yun;  Cen, Jing 收藏  |  浏览/下载：22/0  |  提交时间：2021/12/01 Design and Synthesis of Alkyl Phenols Inhibitors of Death Associated Apoptotic Protein Kinase 2 (DRAK2) 期刊论文 CHINESE JOURNAL OF ORGANIC CHEMISTRY, 2021, 卷号: 41, 期号: 8, 页码: 3204-3213 作者:  Zheng Zhang;  Dai Chengqiu;  Wu Honghong;  Li Jingya;  Nan Fajun 收藏  |  浏览/下载：20/0  |  提交时间：2021/11/04 death associated apoptotic protein kinase 2  diabetes  alkylphenols  inhibitors   Discovery of a potent, selective, and covalent ZAP-70 kinase inhibitor 期刊论文 EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2021, 卷号: 219, 页码: 12 作者:  Rao, Danni;  Li, Heng;  Ren, Xuelian;  Sun, Yaoliang;  Wen, Cuiyun 收藏  |  浏览/下载：28/0  |  提交时间：2021/08/17 Zeta-chain associated protein kinase 70 kDa (ZAP-70)  Covalent inhibitor  T cell  Autoimmune diseases   PROTAC: An Effective Targeted Protein Degradation Strategy for Cancer Therapy 期刊论文 FRONTIERS IN PHARMACOLOGY, 2021, 卷号: 12 作者:  Qi, Si-Min;  Dong, Jinyun;  Xu, Zhi-Yuan;  Cheng, Xiang-Dong;  Zhang, Wei-Dong 收藏  |  浏览/下载：47/0  |  提交时间：2021/06/15 PROTAC  E3 ubiquitin ligase  protein degradation  ubiquitin-proteasome system  cancer therapy   The ups, downs and new trends of IDO1 inhibitors 期刊论文 BIOORGANIC CHEMISTRY, 2021, 卷号: 110, 页码: 12 作者:  Chen, Shulun;  Tan, Jing;  Zhang, Ao 收藏  |  浏览/下载：14/0  |  提交时间：2021/08/17 Immunotherapy  Cancer  Indoleamine 2,3-dioxygenase  Tryptophan 2,3-dioxygenase  Inhibitors  Checkpoint Inhibitor   CSConv2d: A 2-D Structural Convolution Neural Network with a Channel and Spatial Attention Mechanism for Protein-Ligand Binding Affinity Prediction 期刊论文 BIOMOLECULES, 2021, 卷号: 11, 期号: 5, 页码: 9 作者:  Wang, Xun;  Liu, Dayan;  Zhu, Jinfu;  Rodriguez-Paton, Alfonso;  Song, Tao 收藏  |  浏览/下载：20/0  |  提交时间：2021/12/01 protein-ligand binding affinity  2-D structural CNN  spatial attention mechanism