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浏览/检索结果: 共13条，第1-10条 帮助 限定条件 发表日期：2019     已选(0)清除 条数/页：5101520253035404550556065707580859095100   排序方式：请选择作者升序作者降序题名升序题名降序发表日期升序发表日期降序提交时间升序提交时间降序 3-Deoxy-2 beta,16-dihydroxynagilactone E, a natural compound from Podocarpus nagi, preferentially inhibits JAK2/STAT3 signaling by allosterically interacting with the regulatory domain of JAK2 and induces apoptosis of cancer cells 期刊论文 ACTA PHARMACOLOGICA SINICA, 2019, 卷号: 40, 期号: 12, 页码: 1578-1586 作者:  Shan, Hui;  Yao, Sheng;  Ye, Yang;  Yu, Qiang 收藏  |  浏览/下载：9/0  |  提交时间：2020/07/01 JAK/STAT  3-deoxy-2 beta,16-dihydroxynagilactone E  tyrosine kinase inhibitor  allosteric inhibitor  cancer   Targeting epigenetic machinery: Emerging novel allosteric inhibitors 期刊论文 PHARMACOLOGY & THERAPEUTICS, 2019, 卷号: 204, 页码: 24 作者:  Ye, Fei;  Huang, Jing;  Wang, Hongbo;  Luo, Cheng;  Zhao, Kehao 收藏  |  浏览/下载：20/0  |  提交时间：2020/07/01 Epigenetics  PRC2  MLL complex  SWI/SNF  DNMT1  allosteric inhibitors   Tyrosine Kinase 2 (TYK2) Allosteric Inhibitors To Treat Autoimmune Diseases 期刊论文 JOURNAL OF MEDICINAL CHEMISTRY, 2019, 卷号: 62, 期号: 20, 页码: 8951-8952 作者:  Chang, Yu;  Xu, Shilin;  Ding, Ke 收藏  |  浏览/下载：16/0  |  提交时间：2020/07/01 Discovery of DC_H31 as potential mutant IDH1 inhibitor through NADPH-based high throughput screening 期刊论文 BIOORGANIC & MEDICINAL CHEMISTRY, 2019, 卷号: 27, 期号: 15, 页码: 3229-3236 作者:  Duan, Zhe;  Liu, Jingqiu;  Niu, Liping;  Wang, Jun;  Feng, Mingqian 收藏  |  浏览/下载：55/0  |  提交时间：2020/07/01 IDH1 mutation  High-throughput screening  Pan-inhibitor  2-HG  Gliomas   Discovery of Potent and Noncovalent Reversible EGFR Kinase Inhibitors of EGFR(L858R/T790M/C797S) 期刊论文 ACS MEDICINAL CHEMISTRY LETTERS, 2019, 卷号: 10, 期号: 6, 页码: 869-873 作者:  Li, Qiannan;  Zhang, Tao;  Li, Shiliang;  Tong, Linjiang;  Li, Junyu 收藏  |  浏览/下载：20/0  |  提交时间：2020/07/01 EGFR  mutant  inhibitor  C797S   The inhibitory mechanism of aurintricarboxylic acid targeting serine/threonine phosphatase Stp1 in Staphylococcus aureus: insights from molecular dynamics simulations 期刊论文 ACTA PHARMACOLOGICA SINICA, 2019, 卷号: 40, 期号: 6, 页码: 850-858 作者:   收藏  |  浏览/下载：10/0  |  提交时间：2020/07/01 antimicrobial resistance  Staphylococcus aureus  serine/threonine phosphatase  aurintricarboxylic acid  molecular dynamics simulations  flap subdomain   The dynamic conformational landscape of the protein methyltransferase SETD8 期刊论文 ELIFE, 2019, 卷号: 8, 页码: 76 作者:  Chen, Shi;  Wiewiora, Rafal P.;  Meng, Fanwang;  Babault, Nicolas;  Ma, Anqi 收藏  |  浏览/下载：11/0  |  提交时间：2020/07/01 A patent review of arginine methyltransferase inhibitors (2010-2018) 期刊论文 EXPERT OPINION ON THERAPEUTIC PATENTS, 2019, 卷号: 29, 期号: 2, 页码: 97-114 作者:  Li, Xiao;  Wang, Chen;  Jiang, Hao;  Luo, Cheng 收藏  |  浏览/下载：8/0  |  提交时间：2020/07/01 Arginine methylation  Protein arginine methyltransferases (PRMTs)  small molecule inhibitors  drug research and development   Synthesis and biological evaluation of anthraquinone derivatives as allosteric phosphoglycerate mutase 1 inhibitors for cancer treatment 期刊论文 EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2019, 卷号: 168 作者:  Huang, Ke;  Jiang, Lulu;  Liang, Ronghui;  Li, Huiti;  Ruan, Xiaoxue 收藏  |  浏览/下载：8/0  |  提交时间：2019/12/05 Phosphoglycerate mutase 1  Anthraquinone derivatives  Allosteric inhibitors  Cancer treatment   An allosteric switch-based hairpin for label-free chemiluminescence detection of ribonuclease H activity and inhibitors 期刊论文 ANALYST, 2019, 卷号: 144, 期号: 4 作者:  Zhou, Ying;  Zhang, Jingjing;  Jiang, Qian;  Lu, Jianzhong 收藏  |  浏览/下载：13/0  |  提交时间：2019/12/05