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湖南大学 [6]
上海药物研究所 [5]
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期刊论文 [19]
发表日期
2019 [19]
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Design, synthesis, and biological evaluation of thieno[3,2-d]pyrimidine derivatives as potential simplified phosphatidylinositol 3-kinase alpha inhibitors
期刊论文
CHEMICAL BIOLOGY & DRUG DESIGN, 2019, 卷号: 94, 期号: 6, 页码: 2013-2022
作者:
Yang, Xiuyan
;
Deng, Meng
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浏览/下载:75/0
  |  
提交时间:2020/07/01
PI3K alpha inhibitors
proliferation inhibition
thieno[3
2-d]pyrimidine derivatives
Discovery and Biological evaluation of pyrimido[4,5-d] pyrimidine-2,4(1H, 3H)-dione derivatives as potent Bruton's tyrosine kinase inhibitors
期刊论文
BIOORGANIC & MEDICINAL CHEMISTRY, 2019, 卷号: 27, 期号: 15, 页码: 3390-3395
作者:
Diao, Yanyan
;
Fang, Xiaoyu
;
Song, Peiran
;
Lai, Mengzhen
;
Tong, Linjiang
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  |  
浏览/下载:23/0
  |  
提交时间:2020/07/01
Bruton's tyrosine kinase
B-cell malignancies
Potent inhibitors
Structure-activity relationship
Cellular activities
Discovery of pyrimidine nucleoside dual prodrugs and pyrazine nucleosides as novel anti-HCV agents
期刊论文
BIOORGANIC & MEDICINAL CHEMISTRY, 2019, 卷号: 27, 期号: 5, 页码: 748-759
作者:
Guo, Shuang
;
Xu, Mingshuo
;
Guo, Qi
;
Zhu, Fuqiang
;
Jiang, Xiangrui
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  |  
浏览/下载:39/0
  |  
提交时间:2020/07/01
Nucleoside
Double prodrug
Phosphoramidate
Anti-HCV
Pyrazine
Stereoselective N-glycosylation with N-4-acyl cytosines and efficient synthesis of gemcitabine
期刊论文
TETRAHEDRON, 2019, 卷号: 75, 期号: 9, 页码: 1203-1213
作者:
Liu, Tongchao
;
Tang, Jiadeng
;
Liang, Jianpeng
;
Chen, Yabin
;
Wang, Xiaowen
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  |  
浏览/下载:41/0
  |  
提交时间:2020/07/01
Stereoselective
N-glycosylation
N-4-acyl cytosine
Nucleoside
Gemcitabine
A Validated HPLC-MS/MS Assay for 14-O-[(4,6-Diaminopyrimidine-2-yl)thioacetyl] Mutilin in Biological Samples and Its Pharmacokinetic, Distribution and Excretion via Urine and Feces in Rats
期刊论文
MOLECULES, 2019, 卷号: 24, 期号: 4, 页码: 17
作者:
Shang, Ruofeng
;
Fu, Yunxing
;
Liu, Yu
;
Yi, Yunpeng
;
Liang, Jianping
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浏览/下载:70/0
  |  
提交时间:2019/11/10
DPTM
HPLC-MS
MS
pharmacokinetics
distribution
excretion
Design and synthesis of novel pyrimidine derivatives as potent antitubercular agents
期刊论文
European Journal of Medicinal Chemistry, 2019, 卷号: Vol.163, 页码: 169-182
作者:
Pingxian Liu
;
Yunxiang Tang
;
Zhiyong Liu
;
Youfu Luo
;
Tao Yang
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浏览/下载:8/0
  |  
提交时间:2019/04/24
Antimycobacterial
Ceritinib
Pyrimidine
derivatives
Dihydrofolate
reductase
inhibitors
Design and synthesis of novel pyrimidine derivatives as potent antitubercular agents
期刊论文
European Journal of Medicinal Chemistry, 2019, 卷号: Vol.163, 页码: 169-182
作者:
Pingxian Liu
;
Yang Yang
;
Yunxiang Tang
;
Tao Yang
;
Zitai Sang
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  |  
浏览/下载:2/0
  |  
提交时间:2019/12/13
Antimycobacterial
Ceritinib
Pyrimidine
derivatives
Dihydrofolate
reductase
inhibitors
Exploring the hydrophobic channel of NNIBP leads to the discovery of novel piperidine-substituted thiophene[3,2-d]pyrimidine derivatives as potent HIV-1 NNRTIs
期刊论文
Acta Pharmaceutica Sinica B, 2019
作者:
Kang D.
;
Feng D.
;
Ginex T.
;
Zou J.
;
Wei F.
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  |  
浏览/下载:12/0
  |  
提交时间:2019/12/11
HIV-1
Hydrophobic channel
NNIBP
NNRTIs
Thiophene[3,2-d]pyrimidine
Discovery of piperidine-substituted thiazolo[5,4-d]pyrimidine derivatives as potent and orally bioavailable HIV-1 non-nucleoside reverse transcriptase inhibitors
期刊论文
Communications Chemistry, 2019, 卷号: 2, 期号: 1
作者:
Kang D.
;
Zhao T.
;
Wang Z.
;
Feng D.
;
Zhang H.
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  |  
浏览/下载:10/0
  |  
提交时间:2019/12/11
Identification of Dihydrofuro[3,4-d]pyrimidine Derivatives as Novel HIV-1 Non-Nucleoside Reverse Transcriptase Inhibitors with Promising Antiviral Activities and Desirable Physicochemical Properties
期刊论文
JOURNAL OF MEDICINAL CHEMISTRY, 2019, 卷号: 62, 期号: 3, 页码: 1484-1501
作者:
Kang, Dongwei
;
Zhang, Heng
;
Wang, Zhao
;
Zhao, Tong
;
Ginex, Tiziana
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  |  
浏览/下载:3/0
  |  
提交时间:2019/12/11
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