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科研机构
上海药物研究所 [14]
内容类型
期刊论文 [14]
发表日期
2019 [14]
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发表日期:2019
专题:上海药物研究所
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KinomeX: a web application for predicting kinome-wide polypharmacology effect of small molecules
期刊论文
BIOINFORMATICS, 2019, 卷号: 35, 期号: 24, 页码: 5354-5356
作者:
Li, Zhaojun
;
Li, Xutong
;
Liu, Xiaohong
;
Fu, Zunyun
;
Xiong, Zhaoping
收藏
  |  
浏览/下载:79/0
  |  
提交时间:2020/07/01
Targeting epigenetic machinery: Emerging novel allosteric inhibitors
期刊论文
PHARMACOLOGY & THERAPEUTICS, 2019, 卷号: 204, 页码: 24
作者:
Ye, Fei
;
Huang, Jing
;
Wang, Hongbo
;
Luo, Cheng
;
Zhao, Kehao
收藏
  |  
浏览/下载:22/0
  |  
提交时间:2020/07/01
Epigenetics
PRC2
MLL complex
SWI/SNF
DNMT1
allosteric inhibitors
Synthesis of Aryl Propionamide Scaffold Containing a Pentafluorosulfanyl Moiety as SARMs
期刊论文
MOLECULES, 2019, 卷号: 24, 期号: 23, 页码: 13
作者:
Shao, Pingxuan
;
Zhou, Yan
;
Yang, Dehua
;
Wang, Ming-Wei
;
Lu, Wei
收藏
  |  
浏览/下载:3/0
  |  
提交时间:2020/07/01
pentafluorosulfanyl
aryl propionamide
androgen receptor
agonist
SARMs
Enhancing Triple Negative Breast Cancer Immunotherapy by ICG-Templated Self-Assembly of Paclitaxel Nanoparticles
期刊论文
ADVANCED FUNCTIONAL MATERIALS, 2019, 页码: 13
作者:
Feng, Bing
;
Niu, Zifei
;
Hou, Bo
;
Zhou, Lei
;
Li, Yaping
收藏
  |  
浏览/下载:29/0
  |  
提交时间:2020/07/01
immune checkpoint blockade
immunogenic cell death
immunotherapy
self-assemble
triple negative breast cancer
Design, synthesis, and biological evaluation of novel tetrahydroprotoberberine derivatives (THPBs) as proprotein convertase subtilisin/kexin type 9 (PCSK9) modulators for the treatment of hyperlipidemia
期刊论文
ACTA PHARMACEUTICA SINICA B, 2019, 卷号: 9, 期号: 6, 页码: 1216-1230
作者:
Wu, Chenglin
;
Xi, Cong
;
Tong, Junhua
;
Zhao, Jing
;
Jiang, Hualiang
收藏
  |  
浏览/下载:48/0
  |  
提交时间:2020/07/01
PCSK9
Tetrahydroprotoberberine derivatives
Low-density lipoprotein cholesterol
Lipid-lowering
PCSK9 expression
Low-density lipoprotein receptor
Total cholesterol
Hyperlipidemia hamster
Overview of recent advances in liposomal nanoparticle-based cancer immunotherapy
期刊论文
ACTA PHARMACOLOGICA SINICA, 2019, 卷号: 40, 期号: 9, 页码: 1129-1137
作者:
Gao, Ang
;
Hu, Xian-li
;
Saeed, Madiha
;
Chen, Bin-fan
;
Li, Ya-ping
收藏
  |  
浏览/下载:4/0
  |  
提交时间:2020/07/01
immunotherapy
liposomal NPs
dendritic cells
T cells
tumor cells
natural killer cells
macrophages
nanomedicine
Integrating yeast chemical genomics and mammalian cell pathway analysis
期刊论文
ACTA PHARMACOLOGICA SINICA, 2019, 卷号: 40, 期号: 9, 页码: 1245-1255
作者:
Zhou, Fu-lai
;
Li, Sheena C.
;
Zhu, Yue
;
Guo, Wan-jing
;
Shao, Li-jun
收藏
  |  
浏览/下载:11/0
  |  
提交时间:2020/07/01
yeast
chemical genomics
tubulin cytoskeleton assembly
autophagy
Wnt/beta-catenin signaling pathway
A Small-Molecule Compound Selectively Activates K2P Channel TASK-3 by Acting at Two Distant Clusters of Residues
期刊论文
MOLECULAR PHARMACOLOGY, 2019, 卷号: 96, 期号: 1, 页码: 26-35
作者:
Tian, Fuyun
;
Qiu, Yunguang
;
Lan, Xi
;
Li, Min
;
Yang, Huaiyu
收藏
  |  
浏览/下载:18/0
  |  
提交时间:2020/07/01
Deep Neural Network Classifier for Virtual Screening Inhibitors of (S)-Adenosyl-L-Methionine (SAM)-Dependent Methyltransferase Family
期刊论文
FRONTIERS IN CHEMISTRY, 2019, 卷号: 7, 页码: 17
作者:
Li, Fei
;
Wan, Xiaozhe
;
Xing, Jing
;
Tan, Xiaoqin
;
Li, Xutong
收藏
  |  
浏览/下载:7/0
  |  
提交时间:2020/07/01
deep neural network
virtual screening
methyltransferase
epigenetic
drug design
Treatment of Chronic Hepatitis B Virus Infection Using Small Molecule Modulators of Nucleocapsid Assembly: Recent Advances and Perspectives
期刊论文
ACS INFECTIOUS DISEASES, 2019, 卷号: 5, 期号: 5, 页码: 713-724
作者:
Yang, Li
;
Liu, Feifei
;
Tong, Xiankun
;
Hoffmann, Daniel
;
Zuo, Jianping
收藏
  |  
浏览/下载:25/0
  |  
提交时间:2020/07/01
hepatitis B virus
HBV core protein
HBcAg
capsid assembly
capsid assembly modulators (CAMs)
antiviral therapy
clinical trials
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