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上海药物研究所 [10]
山东大学 [4]
复旦大学上海医学院 [4]
武汉大学 [3]
昆明医科大学 [3]
中南大学 [2]
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期刊论文 [38]
发表日期
2018 [38]
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High-throughput screening campaigns against a PI3K alpha isoform bearing the H1047R mutation identified potential inhibitors with novel scaffolds
期刊论文
ACTA PHARMACOLOGICA SINICA, 2018, 卷号: 39, 期号: 11, 页码: 1816-1822
作者:
Wang, Jia
;
Gong, Grace Qun
;
Zhou, Yan
;
Lee, Woo-Jeong
;
Buchanan, Christina Maree
收藏
  |  
浏览/下载:84/0
  |  
提交时间:2019/01/08
high throughput screening
PI3 kinase
PI3K alpha H1047R
inhibitors
molecular modeling
Design, Synthesis, and Biological Evaluation of Thieno[3,2-d]pyrimidine Derivatives as Potential Simplified Phosphatidylinositol 3-Kinase alpha (PI3Kα) inhibitors
期刊论文
Chemical biology & drug design, 2018
作者:
Yang, Xiuyan
;
Deng, Meng
;
Zhang, Xi
;
Song, Kun
;
Ruan, Cong
收藏
  |  
浏览/下载:36/0
  |  
提交时间:2019/01/08
Synthesis, biological evaluation and structure-activity relationship of a novel class of PI3K alpha H1047R mutant inhibitors
期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2018, 卷号: 158, 页码: 707-719
作者:
Zhang, Ning
;
Yu, Zhimei
;
Yang, Xiaohong
;
Zhou, Yan
;
Wang, Jia
收藏
  |  
浏览/下载:84/0
  |  
提交时间:2019/01/08
Anticancer drug
Phosphatidylinositol 3-kinase
Structure-activity relationship
Difuran-substituted quinoxalines as a novel class of PI3K alpha H1047R mutant inhibitors: Synthesis, biological evaluation and structure activity relationship
期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2018, 卷号: 157, 页码: 37-49
作者:
Zhang, Ning
;
Yu, Zhimei
;
Yang, Xiaohong
;
Zhou, Yan
;
Tang, Qing
收藏
  |  
浏览/下载:26/0
  |  
提交时间:2019/01/08
Proliferation
Anticancer drug
Phosphatidylinositol 3-kinase inhibitor
Apoptosis
Structure-activity relationship
Serum and glucocorticoid inducible protein kinases (SGKs): a potential target for cancer intervention
期刊论文
ACTA PHARMACEUTICA SINICA B, 2018, 卷号: 8, 期号: 5, 页码: 767-771
作者:
Basnet, Rajesh
;
Gong, Grace Qun
;
Li, Chenyao
;
Wang, Ming-Wei
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  |  
浏览/下载:30/0
  |  
提交时间:2019/01/08
SGK
AKT
PI3K
Cancer
Signalling: Kinase
Inhibitor
Phosphatidylinositol 3-Kinase-DNA Methyltransferase 1-miR-1281-Histone Deacetylase 4 Regulatory Axis Mediates Platelet-Derived Growth Factor-Induced Proliferation and Migration of Pulmonary Artery Smooth Muscle Cells.
期刊论文
JOURNAL OF THE AMERICAN HEART ASSOCIATION, 2018
作者:
Li, Yanjiao
;
Raj, J. Usha
;
Qu, Junle
;
Luo, Yixuan
;
Chen, Jidong
收藏
  |  
浏览/下载:36/0
  |  
提交时间:2019/01/31
Photothermal therapy with AuNRs and EGFRmAb-AuNRs inhibits subcutaneous transplantable hypopharyngeal tumors in nude mice
期刊论文
INTERNATIONAL JOURNAL OF ONCOLOGY, 2018, 卷号: 53, 期号: 6
作者:
Zhang, Yingying
;
He, Jiayan
;
Wang, Yu
;
Wen, Jinya
;
Zou, Yingying
收藏
  |  
浏览/下载:12/0
  |  
提交时间:2019/12/04
gold nanorods
photothermal therapy
epidermal growth factor receptor monoclonal antibody
phosphatidylinositol-3-kinase/AKT serine/threonine kinase signaling pathway
DNA damage signaling pathway
Silence of alpha 1-Antitrypsin Inhibits Migration and Proliferation of Triple Negative Breast Cancer Cells
期刊论文
MEDICAL SCIENCE MONITOR, 2018, 卷号: 24
作者:
Zhao, Zhijing
;
Ma, Junfeng
;
Mao, Ying
;
Dong, Liying
;
Li, Siqi
收藏
  |  
浏览/下载:13/0
  |  
提交时间:2019/12/04
Adrenergic alpha-1 Receptor Antagonists
Phosphatidylinositol 3-Kinase
Transcellular Cell Migration
Trip Negative Breast Neoplasms
Genetic diversity of the Plasmodium vivax phosphatidylinositol 3-kinase gene in two regions of the China-Myanmar border
期刊论文
INFECTION GENETICS AND EVOLUTION, 2018, 卷号: 61
作者:
Mbenda, Huguette Gaelle Ngassa
;
Zeng, Weilin
;
Bai, Yao
;
Siddiqui, Faiza Amber
;
Yang, Zhaoqing
收藏
  |  
浏览/下载:5/0
  |  
提交时间:2019/12/04
Artemisinin resistance
Plasmodium vivax-PI3K
Southeast Asia
Genetic diversity
China-Myanmar border
2-Methoxyestradiol inhibits hypoxia-induced scleroderma fibroblast collagen synthesis by phosphatidylinositol 3-kinase/Akt/mTOR signalling
期刊论文
RHEUMATOLOGY, 2018, 卷号: 57, 期号: 9
作者:
Zhou, Xing
;
Liu, Chaofan
;
Lu, Jinghao
;
Zhu, Lubing
;
Li, Ming
收藏
  |  
浏览/下载:5/0
  |  
提交时间:2019/12/05
2-Methoxyestradiol
hypoxia
fibroblast
collagen
systemic sclerosis
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