QQ客服 官方微博 反馈留言

浏览/检索结果: 共7条，第1-7条 帮助 限定条件 发表日期：2018     已选(0)清除 条数/页：5101520253035404550556065707580859095100   排序方式：请选择作者升序作者降序题名升序题名降序发表日期升序发表日期降序提交时间升序提交时间降序 Discovery and biological evaluation of thiobarbituric derivatives as potent p300/CBP inhibitors 期刊论文 BIOORGANIC & MEDICINAL CHEMISTRY, 2018, 卷号: 26, 期号: 20, 页码: 5397-5407 作者:  Lu, Wenchao;  Xiong, Huan;  Chen, Yu;  Wang, Chen;  Zhang, Hao 收藏  |  浏览/下载：138/0  |  提交时间：2019/01/08 Drug discovery  Epigenetics  Histone acetyltransferase  P300/CBP   Acquired resistance of phosphatase and tensin homolog-deficient cells to poly(ADP-ribose) polymerase inhibitor and Ara-C mediated by 53BP1 loss and SAMHD1 overexpression 期刊论文 CANCER SCIENCE, 2018, 卷号: 109, 期号: 3, 页码: 821-831 作者:  Wang, Yu-Ting;  Yuan, Bo;  Chen, Hua-Dong;  Xu, Lin;  Tian, Yu-Nan 收藏  |  浏览/下载：43/0  |  提交时间：2019/01/08 53BP1  acquired resistance  phosphatase and tensin homolog deficiency  poly(ADP-ribose) polymerase inhibitors  SAMHD1   Design and synthesis of 2-(4,5,6,7-tetrahydrothienopyridin-2-yl)-benzoimidazole carboxamides as novel orally efficacious Poly(ADP-ribose)polymerase (PARP) inhibitors 期刊论文 EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2018, 卷号: 145, 页码: 389-403 作者:  Chen, Xuxing;  Huan, Xiajuan;  Liu, Qiufeng;  Wang, Yuqin;  He, Qian 收藏  |  浏览/下载：31/0  |  提交时间：2019/01/08 PARP1/2 inhibitor  Benzimidazole  4,5,6,7-Tetrahydrothienopyridine  Co-crystal structure  Isothermal Titration Calorimetry   Inhibition of MUS81 improves the chemical sensitivity of olaparib by regulating MCM2 in epithelial ovarian cancer 期刊论文 ONCOLOGY REPORTS, 2018, 卷号: 39, 期号: 4 作者:  Zhong, Ailing;  Zhang, Hongqin;  Xie, Suhong;  Deng, Minjie;  Zheng, Hui 收藏  |  浏览/下载：9/0  |  提交时间：2019/12/05 MUS81  MCM2  homologous recombination  PARP inhibitors  epithelial ovarian cancer   In silico identification of AChE and PARP-1 dual-targeted inhibitors of Alzheimer's disease 期刊论文 Journal of molecular modeling, 2018, 卷号: 24, 页码: 151 作者:  Hu Xia-Min[1];  Dong Wei[2];  Cui Zhi-Wen[3];  Gao Cheng-Zhi[4];  Yu Zhi-Jun[5] 收藏  |  浏览/下载：10/0  |  提交时间：2019/04/22 AChE  Alzheimer’s disease  Molecular dynamics  PARP-1  Virtual screening   In silico identification of AChE and PARP-1 dual-targeted inhibitors of Alzheimer's disease 期刊论文 JOURNAL OF MOLECULAR MODELING, 2018, 卷号: 24, 期号: 7 作者:  Hu, Xia-Min;  Dong, Wei;  Cui, Zhi-Wen;  Gao, Cheng-Zhi;  Yu, Zhi-Jun 收藏  |  浏览/下载：3/0  |  提交时间：2019/12/06 Discovery of quinazoline-2,4(1H,3H)-dione derivatives as novel PARP-1/2 inhibitors: design, synthesis and their antitumor activity 期刊论文 2018, 卷号: 16, 期号: 17, 页码: 3189-3202 作者:  Zhou, Jie;  Ji, Ming;  Yao, Haiping;  Cao, Ran;  Zhao, Hailong 收藏  |  浏览/下载：7/0  |  提交时间：2020/01/03