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上海药物研究所 [4]
四川大学 [3]
昆明植物研究所 [1]
山东大学 [1]
上海大学 [1]
上海中医药大学 [1]
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期刊论文 [11]
发表日期
2018 [11]
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Scutellarin alleviates blood-retina-barrier oxidative stress injury initiated by activated microglia cells during the development of diabetic retinopathy
期刊论文
Biochemical pharmacology, 2018, 卷号: 159, 页码: 82-95
作者:
Mei, Xiyu
;
Zhang, Tianyu
;
Ouyang, Hao
;
Lu, Bin
;
Wang, Zhengtao
收藏
  |  
浏览/下载:32/0
  |  
提交时间:2019/01/08
Targeting ERK, an Achilles' Heel of the MAPK pathway, in cancer therapy
期刊论文
ACTA PHARMACEUTICA SINICA B, 2018, 卷号: 8, 期号: 4, 页码: 552-562
作者:
Liu, Feifei
;
Yang, Xiaotong
;
Geng, Meiyu
;
Huang, Min
收藏
  |  
浏览/下载:33/0
  |  
提交时间:2019/01/08
Mitogen-activated protein kinases
Extracellular signal-regulated kinase
ERK inhibitor
ERK kinase
Cancer therapy
Drug resistance
Aberrant modulation of ribosomal protein S6 phosphorylation confers acquired resistance to MAPK pathway inhibitors in BRAF-mutant melanoma
期刊论文
Acta pharmacologica Sinica, 2018
作者:
Gao, Ming-Zhao
;
Wang, Hong-Bin
;
Chen, Xiang-Ling
;
Cao, Wen-Ting
;
Fu, Li
收藏
  |  
浏览/下载:23/0
  |  
提交时间:2019/01/08
Phosphodiesterase 4 Inhibitor Roflumilast Protects Rat Hippocampal Neurons from Sevoflurane Induced Injury via Modulation of MEK/ERK Signaling Pathway
期刊论文
CELLULAR PHYSIOLOGY AND BIOCHEMISTRY, 2018, 卷号: 45, 期号: 6
作者:
Peng, Sheng
;
Yan, Hong-Zhu
;
Liu, Pei-Rong
;
Shi, Xiao-Wei
;
Liu, Chun-Liang
收藏
  |  
浏览/下载:10/0
  |  
提交时间:2019/12/05
Sevoflurane
Nerve damage
Roflumilast
CAMP
Phosphodiesterase 4 inhibitor (PDE-4i)
MEK/ERK pathway
Vibsanin A sensitizes human acute myeloid leukemia cells to tyrosine kinase inhibitor-induced myeloid differentiation via activation of PKC and upregulation of Lyn
期刊论文
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2018, 卷号: 502, 期号: 1, 页码: 110-115
作者:
Shen, Xing
;
Xing, Shuang
;
Zhang, Lu
;
Wang, Fangmin
;
Ou, Hongling
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  |  
浏览/下载:58/0
  |  
提交时间:2019/03/29
Efficacy of the MEK Inhibitor Cobimetinib and its Potential Application to Colorectal Cancer Cells.
期刊论文
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology, 2018, 卷号: Vol.47 No.2, 页码: 680-693
作者:
Gong, S
;
Xu, DS
;
Zhu, JL
;
Zou, FD
;
Peng, R
收藏
  |  
浏览/下载:1/0
  |  
提交时间:2019/02/25
Cancer therapy
Cobimetinib
Colorectal Cancer
Thymidylate synthetase
Phosphodiesterase 4 Inhibitor Roflumilast Protects Rat Hippocampal Neurons from Sevoflurane Induced Injury via Modulation of MEK/ERK Signaling Pathway
期刊论文
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology, 2018, 卷号: 45, 页码: 2329-2337
作者:
Peng Sheng[1]
;
Yan Hong-Zhu[2]
;
Liu Pei-Rong[3]
;
Shi Xiao-Wei[4]
;
Liu Chun-Liang[5]
收藏
  |  
浏览/下载:7/0
  |  
提交时间:2019/04/24
CAMP
MEK/ERK pathway
Nerve damage
Phosphodiesterase 4 inhibitor (PDE-4i)
Roflumilast
Sevoflurane
ERRα suppression enhances the cytotoxicity of the MEK inhibitor trametinib against colon cancer cells
期刊论文
Journal of Experimental & Clinical Cancer Research, 2018, 卷号: Vol.37 No.1, 页码: 1-14
作者:
Sheng Zhou
;
Hongwei Xia
;
Huanji Xu
;
Qiulin Tang
;
Yongzhan Nie
收藏
  |  
浏览/下载:4/0
  |  
提交时间:2019/02/25
Oestrogen-related
receptor
α
(ERRα)
Epidermal
growth
factor
(EGF)
Trametinib
Simvastatin
ERRα suppression enhances the cytotoxicity of the MEK inhibitor trametinib against colon cancer cells
期刊论文
Journal of Experimental & Clinical Cancer Research, 2018, 卷号: Vol.37 No.1, 页码: 1-14
作者:
Sheng Zhou
;
Hongwei Xia
;
Huanji Xu
;
Qiulin Tang
;
Yongzhan Nie
收藏
  |  
浏览/下载:8/0
  |  
提交时间:2019/02/25
Oestrogen-related
receptor
α
(ERRα)
Epidermal
growth
factor
(EGF)
Trametinib
Simvastatin
The impact of P-glycoprotein and breast cancer resistance protein on the brain pharmacokinetics and pharmacodynamics of a panel of MEK inhibitors
期刊论文
INTERNATIONAL JOURNAL OF CANCER, 2018, 卷号: 142, 期号: 2, 页码: 381-391
作者:
de Gooijer, Mark C.
;
Zhang, Ping
;
Weijer, Ruud
;
Buil, Levi C. M.
;
Beijnen, Jos H.
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  |  
浏览/下载:4/0
  |  
提交时间:2019/12/11
glioma
pharmacokinetics
MEK inhibitor
ABC transporters
blood-brain-barrier
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