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上海药物研究所 [115]
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Design, synthesis, and bioactivity evaluation of novel Bcl-2/HDAC dual-target inhibitors for the treatment of multiple myeloma
期刊论文
Bioorganic & medicinal chemistry letters, 2018
作者:
Zhou, Ruolan
;
Fang, Shaoyu
;
Zhang, Minmin
;
Zhang, Qingsen
;
Hu, Jian
收藏
  |  
浏览/下载:97/0
  |  
提交时间:2019/01/08
Hydrolytic Metabolism of Cyanopyrrolidine DPP-4 Inhibitors Mediated by Dipeptidyl Peptidases
期刊论文
Drug metabolism and disposition: the biological fate of chemicals, 2018
作者:
Kong, Fandi
;
Pang, Xiaoyan
;
Zhao, Jihui
;
Deng, Pan
;
Zheng, Mingyue
收藏
  |  
浏览/下载:82/0
  |  
提交时间:2019/01/08
A "Ship-in-a-Bottle" strategy to create folic acid nanoclusters inside the nanocages of γ-cyclodextrin metal-organic frameworks
期刊论文
International journal of pharmaceutics, 2018, 卷号: 556, 页码: 89-96
作者:
Xu, Jian
;
Wu, Li
;
Guo, Tao
;
Zhang, Guoqing
;
Wang, Caifen
收藏
  |  
浏览/下载:86/0
  |  
提交时间:2019/01/08
Reconsideration of Anticholinesterase Therapeutic Strategies against Alzheimer's Disease
期刊论文
ACS chemical neuroscience, 2018
作者:
Wang, Huan
;
Zhang, Haiyan
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  |  
浏览/下载:58/0
  |  
提交时间:2019/01/08
Discovery of (E)-N-(4-((4-methylpiperazin-1-yl)methyl)-3-(trifluoromethyl)phenyl)-3-((3-(2-(pyridin-2-yl)vinyl)-1H-indazol-6-yl)thio)propanamide (CHMFL-ABL-121) as a highly potent ABL kinase inhibitor capable of overcoming a variety of ABL mutants including T315I for chronic myeloid leukemia
期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2018, 卷号: 160, 页码: 61-81
作者:
Liu, Xuesong
;
Wang, Beilei
;
Chen, Cheng
;
Jiang, Zongru
;
Hu, Chen
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  |  
浏览/下载:14/0
  |  
提交时间:2019/01/11
ABL kinase
Kinase inhibitor
ABL mutant
CML
iTRAQ-Based Quantitative Proteomic Analysis of a Toxigenic Dinoflagellate Alexandrium catenella at Different Stages of Toxin Biosynthesis during the Cell Cycle
期刊论文
MARINE DRUGS, 2018, 卷号: 16, 期号: 12
作者:
Zhang, Shu-Fei
;
Zhang, Yong
;
Lin, Lin
;
Wang, Da-Zhi
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  |  
浏览/下载:38/0
  |  
提交时间:2019/07/15
dinoflagellates
Alexandrium catenella
paralytic shellfish toxins
cell cycle
toxin biosynthesis
quantitative proteomics
iTRAQ
Discovery of novel antagonists on (2)-adrenoceptor from natural products using a label-free cell phenotypic assay
期刊论文
NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY, 2018, 卷号: 391, 期号: 12, 页码: 1411-1420
作者:
Wang, Anhui
;
Zhang, Pengyu
;
Wang, Jixia
;
Zhao, Ying
;
Zhang, Xiuli
收藏
  |  
浏览/下载:56/0
  |  
提交时间:2019/06/20
beta(2)-Adrenoceptor
Antagonist
Natural product
Label-free cell phenotypic assay
Hyperbranched mixed-mode anion-exchange polymeric sorbent for highly selective extraction of nine acidic non-steroidal anti-inflammatory drugs from human urine
期刊论文
TALANTA, 2018, 卷号: 190, 页码: 15-22
作者:
Wang, Longxing
;
Chen, Jiping
;
Huang, Chaonan
;
Li, Yun
;
Yang, Jiajia
收藏
  |  
浏览/下载:52/0
  |  
提交时间:2019/06/20
Quatemized hyperbranched macromolecules
Poly(divinylbenzene)
Mixed-mode anion-exchange SPE
Acidic NSAIDs
Human urine
Prioritizing predictive biomarkers for gene essentiality in cancer cells with mRNA expression data and DNA copy number profile
期刊论文
BIOINFORMATICS, 2018, 卷号: 34, 期号: 23, 页码: 3975-3982
作者:
Guan, Yuanfang
;
Li, Tingyang
;
Zhang, Hongjiu
;
Zhu, Fan
;
Omenn, Gilbert S.
收藏
  |  
浏览/下载:14/0
  |  
提交时间:2019/01/17
Novel ultra-small micelles based on rebaudioside A: A potential nanoplatform for ocular drug delivery
期刊论文
INTERNATIONAL JOURNAL OF PHARMACEUTICS, 2018, 卷号: 552, 期号: 1-2, 页码: 265-276
作者:
Song, Kaichao
;
Xin, Meng
;
Yu, Hongxia
;
Zheng, Zhou
;
Li, Jun
收藏
  |  
浏览/下载:10/0
  |  
提交时间:2019/08/19
Rebaudioside A
Coumarin-6
Micelle
Ocular drug delivery
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