Reconsideration of Anticholinesterase Therapeutic Strategies against Alzheimer's Disease

doi:10.1021/acschemneuro.8b00391

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	Reconsideration of Anticholinesterase Therapeutic Strategies against Alzheimer's Disease
	Wang, Huan; Zhang, Haiyan
刊名	ACS chemical neuroscience
	2018-12-06
ISSN号	1948-7193
DOI	10.1021/acschemneuro.8b00391
文献子类	Article
英文摘要	Alzheimer's disease (AD) is well-known as a severe neurodegeneration disease involving complicated etiologies, and cholinesterase inhibition remain the prevailing mode of clinical intervention in AD management. Although most clinically applied cholinesterase inhibitors (ChEIs) achieve limited clinical outcomes, research on the central cholinergic system is still thriving. Recently, an impressive amount of knowledge regarding novel acetylcholinesterase functions, as well as the close association between the central cholinergic system and other key elements for AD pathogenesis, has accumulated, highlighting that this field still has great potential for future drug development. In contrast to the overwhelmingly disappointing clinical therapeutic effects of various disease-modifying drug candidates, interesting evidence has continued to emerge over the past 20 years from the wealth of preclinical and clinical data on the usage of ChEIs, indicating underestimated clinical benefits due to physician ambivalence, a lack of persistent treatment, and inappropriate medication times or doses. Here we pinpoint several topics fit for future attention, focusing on the updated cholinergic hypothesis, especially the pleiotropic relationships with key pathogenetic signaling pathways and functions in AD, as well as possible novel therapeutic strategies, including novel ChEIs and cholinesterase inhibition-based innovative multifunctional therapeutic candidates. We intend to strengthen the future value of the precise application of cholinergic drugs, especially novel ChEIs, as a cornerstone pharmacological approach to AD treatment, either alone or in combination with other targets, to relieve symptoms and to modify disease progression.
语种	英语
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/266253]
专题	药理学第二研究室
作者单位	CAS Key Laboratory of Receptor Research , Shanghai Institute of Materia Medica, Chinese Academy of Sciences , 555 Zu Chong Zhi Road , Shanghai 201203 , China
推荐引用方式 GB/T 7714	Wang, Huan,Zhang, Haiyan. Reconsideration of Anticholinesterase Therapeutic Strategies against Alzheimer's Disease[J]. ACS chemical neuroscience,2018.
APA	Wang, Huan,&Zhang, Haiyan.(2018).Reconsideration of Anticholinesterase Therapeutic Strategies against Alzheimer's Disease.ACS chemical neuroscience.
MLA	Wang, Huan,et al."Reconsideration of Anticholinesterase Therapeutic Strategies against Alzheimer's Disease".ACS chemical neuroscience (2018).