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浏览/检索结果: 共15条，第1-10条 帮助 限定条件 发表日期：2018    专题：上海药物研究所    第一署名单位    第一作者单位    通讯作者单位     已选(0)清除 条数/页：5101520253035404550556065707580859095100   排序方式：请选择作者升序作者降序题名升序题名降序发表日期升序发表日期降序提交时间升序提交时间降序 Discovery of new potent protein arginine methyltransferase 5 (PRMT5) inhibitors by assembly of key pharmacophores from known inhibitors 期刊论文 BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2018, 卷号: 28, 期号: 23-24, 页码: 3693-3699 作者:  Zhu, Kongkai;  Song, Jia-Li;  Tao, Hong-Rui;  Cheng, Zhi-Qiang;  Jiang, Cheng-Shi 收藏  |  浏览/下载：100/0  |  提交时间：2019/01/08 Pharmacophore combination  Isoquinoline  PRMT5 inhibitor  Molecular docking  Molecular dynamics simulation   Identification of 5-benzylidene-2-phenylthiazolones as potent PRMT5 inhibitors by virtual screening, structural optimization and biological evaluations 期刊论文 BIOORGANIC CHEMISTRY, 2018, 卷号: 81, 页码: 289-298 作者:  Zhu, Kongkai;  Tao, Hongrui;  Song, Jia-Li;  Jin, Lu;  Zhang, Yuanyuan 收藏  |  浏览/下载：129/0  |  提交时间：2019/01/08 PRMT5 inhibitor  Arginine methylation  Virtual screening  Molecular docking  Molecular dynamics simulation   Molecular modelling studies on cinnoline-based BTK inhibitors using docking and structure-based 3D-QSAR 期刊论文 SAR AND QSAR IN ENVIRONMENTAL RESEARCH, 2018, 卷号: 29, 期号: 11, 页码: 847-873 作者:  Li, R.;  Du, Y.;  Shen, J. 收藏  |  浏览/下载：36/0  |  提交时间：2019/01/08 BTK inhibitors  B-cell malignancies  molecule docking  3D-QSAR  CoMFA  CoMSIA   Targeting the PI3K/Akt/mTOR signaling pathway by pterostilbene attenuates mantle cell lymphoma progression 期刊论文 ACTA BIOCHIMICA ET BIOPHYSICA SINICA, 2018, 卷号: 50, 期号: 8, 页码: 782-792 作者:  Yu, Dandan;  Zhang, Yong;  Chen, Gege;  Xie, Yongsheng;  Xu, Zhijian 收藏  |  浏览/下载：52/0  |  提交时间：2019/01/08 mantle cell lymphoma  pterostilbene  antiproliferative activity  PI3K/Akt/mTOR pathway  synergistic cytotoxicity   Dihydrocelastrol exerts potent antitumor activity in mantle cell lymphoma cells via dual inhibition of mTORC1 and mTORC2 期刊论文 INTERNATIONAL JOURNAL OF ONCOLOGY, 2018, 卷号: 53, 期号: 2, 页码: 823-834 作者:  Xie, Yongsheng;  Li, Bo;  Bu, Wenxuan;  Gao, Lu;  Zhang, Yong 收藏  |  浏览/下载：98/0  |  提交时间：2019/01/08 mantle cell lymphoma  dihydrocelastrol  apoptosis  cell cycle  mTORC1  mTORC2   DCZ3301, a novel aryl-guanidino inhibitor, induces cell apoptosis and cell cycle arrest via suppressing the PI3K/AKT pathway in T-cell leukemia/lymphoma 期刊论文 ACTA BIOCHIMICA ET BIOPHYSICA SINICA, 2018, 卷号: 50, 期号: 7, 页码: 643-650 作者:  Xiao, Wenqin;  Li, Bo;  Sun, Xi;  Yu, Dandan;  Xie, Yongsheng 收藏  |  浏览/下载：82/0  |  提交时间：2019/01/08 DCZ3301  T-cell leukemia/lymphoma  apoptosis  cell cycle  PI3K/AKT   Design, synthesis and pharmacological evaluation of ALK and Hsp90 dual inhibitors bearing resorcinol and 2,4-diaminopyrimidine motifs 期刊论文 EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2018, 卷号: 152, 页码: 76-86 作者:  Geng, Kaijun;  Liu, Hongchun;  Song, Zilan;  Zhang, Chi;  Zhang, Minmin 收藏  |  浏览/下载：148/0  |  提交时间：2019/01/08 Heat shock protein 90 (Hsp90)  Tyrosine kinase ALK  Dual inhibitor  Drug resistance  Antiproliferative activity   Discovery of 4,7-Diamino-5-(4-phenoxyphenyl)-6-methylene-pyrinnido[5,4-b]pyrrolizines as Novel Bruton's Tyrosine Kinase Inhibitors 期刊论文 JOURNAL OF MEDICINAL CHEMISTRY, 2018, 卷号: 61, 期号: 10, 页码: 4608-4627 作者:  Xue, Yu;  Song, Peiran;  Song, Zilan;  Wang, Aoli;  Tong, Linjiang 收藏  |  浏览/下载：36/0  |  提交时间：2019/01/08 Identification of Selective, Cell Active Inhibitors of Protein Arginine Methyltransferase 5 through Structure-Based Virtual Screening and Biological Assays 期刊论文 JOURNAL OF CHEMICAL INFORMATION AND MODELING, 2018, 卷号: 58, 期号: 5, 页码: 1066-1073 作者:  Ye, Fei;  Zhang, Weiyao;  Ye, Xiaoqing;  Jin, Jia;  Lv, Zhengbing 收藏  |  浏览/下载：15/0  |  提交时间：2019/01/08 The chemical diversity and structure-based evolution of non-peptide CXCR4 antagonists with diverse therapeutic potential 期刊论文 EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2018, 卷号: 149, 页码: 148-169 作者:  Peng, Dian;  Cao, Bin;  Zhou, Ying-Jun;  Long, Ya-Qiu 收藏  |  浏览/下载：38/0  |  提交时间：2019/01/08 CXC chemokine receptor 4  Small molecule antagonists  Structure-based optimization  HIV-1 entry  Tumor metastasis  Inflammation  Ischemia-reperfusion  Autoimmune