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浏览/检索结果: 共125条，第1-10条 帮助 限定条件 发表日期：2017    内容类型：期刊论文    专题：上海药物研究所    第一署名单位    第一作者单位    通讯作者单位     已选(0)清除 条数/页：5101520253035404550556065707580859095100   排序方式：请选择作者升序作者降序题名升序题名降序发表日期升序发表日期降序提交时间升序提交时间降序 Pharmacologic characterization of SHR8443, a novel dual inhibitor of phosphatidylinositol 3-kinase and mammalian target of rapamycin 期刊论文 ONCOTARGET, 2017, 卷号: 8, 期号: 64, 页码: 107977-107990 作者:  Xie, Chengying;  Chen, Xiangling;  Zheng, Mingyue;  Liu, Xiaohong;  Wang, Hongbin 收藏  |  浏览/下载：27/0  |  提交时间：2019/01/08 BEZ235  drug resistance  mTOR  PI3K  SHR8443   Synthesis and biological evaluation of novel 4,5-bisindolyl-1,2,4-triazol-3-ones as glycogen synthase kinase-3 beta inhibitors and neuroprotective agents 期刊论文 PHARMAZIE, 2017, 卷号: 72, 期号: 12, 页码: 707-713 作者:  Hu, Yuanyuan;  Ruan, Wenchen;  Gao, Anhui;  Zhou, Yubo;  Gao, Lixin 收藏  |  浏览/下载：28/0  |  提交时间：2019/01/08 Hypoxia induces universal but differential drug resistance and impairs anticancer mechanisms of 5-fluorouracil in hepatoma cells 期刊论文 ACTA PHARMACOLOGICA SINICA, 2017, 卷号: 38, 期号: 12, 页码: 1642-1654 作者:  Li, Jing-qiu;  Wu, Xian;  Gan, Lu;  Yang, Xiang-liang;  Miao, Ze-hong 收藏  |  浏览/下载：32/0  |  提交时间：2019/01/08 hepatocellular carcinoma  hypoxia  5-fluorouracil  sorafenib  drug resistance   Co-delivery of docetaxel and silibinin using pH-sensitive micelles improves therapy of metastatic breast cancer 期刊论文 ACTA PHARMACOLOGICA SINICA, 2017, 卷号: 38, 期号: 12, 页码: 1655-1662 作者:  Dong, Xin-yue;  Lang, Tian-qun;  Yin, Qi;  Zhang, Peng-cheng;  Li, Ya-ping 收藏  |  浏览/下载：28/0  |  提交时间：2019/01/08 pH-sensitive polymer  co-delivery  micelle  docetaxel  silibinin  breast cancer  mouse breast cancer cell line 4T1  metastasis   6-Methoxyethylamino-numonafide inhibits hepatocellular carcinoma xenograft growth as a single agent and in combination with sorafenib 期刊论文 FASEB JOURNAL, 2017, 卷号: 31, 期号: 12, 页码: 5453-5465 作者:  Liu, Yanning;  Lou, Guohua;  Norton, John T.;  Wang, Chen;  Kandela, Irawati 收藏  |  浏览/下载：23/0  |  提交时间：2019/01/08 MEAN  HCC therapeutic  combination treatment  C-MYC inhibition   Design and synthesis of Atglistatin derivatives as adipose triglyceride lipase inhibitors 期刊论文 CHEMICAL BIOLOGY & DRUG DESIGN, 2017, 卷号: 90, 期号: 6, 页码: 1122-1133 作者:  Jin, Jiyu;  Huang, Suling;  Wang, Lei;  Leng, Ying;  Lu, Wei 收藏  |  浏览/下载：20/0  |  提交时间：2019/01/08 adipose triglyceride lipase inhibitors  Atglistatin  structure-activity relationship  thiourea   Discovery and structure-activity-relationship study of novel conformationally restricted indane analogues for mutant isocitric dehydrogenase 1 (IDH1) inhibitors 期刊论文 BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2017, 卷号: 27, 期号: 23, 页码: 5262-5266 作者:  Zheng, Qiangang;  Tang, Shuai;  Fu, Xianlei;  Chen, Ziqi;  Ye, Yan 收藏  |  浏览/下载：33/0  |  提交时间：2019/01/08 IDH1 inhibitor  Indane amide  Structure-based rational design   Discovery of a class of diheteroaromatic amines as orally bioavailable CDK1/4/6 inhibitors 期刊论文 BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2017, 卷号: 27, 期号: 23, 页码: 5332-5336 作者:  Fu, Yan;  Tang, Shuai;  Su, Yi;  Lan, Xiaojing;  Ye, Yan 收藏  |  浏览/下载：26/0  |  提交时间：2019/01/08 Cyclin-dependent kinase  CDK inhibitor  Structure-activity relationship  In vitro and in vivo profiling   Novel Vilazodone Tacrine Hybrids as Potential Multitarget-Directed Ligands for the Treatment of Alzheimer's Disease Accompanied with Depression: Design, Synthesis, and Biological Evaluation 期刊论文 ACS CHEMICAL NEUROSCIENCE, 2017, 卷号: 8, 期号: 12, 页码: 2708-2721 作者:  Li, Xiaokang;  Wang, Huan;  Xu, Yixiang;  Liu, Wenwen;  Gong, Qi 收藏  |  浏览/下载：36/0  |  提交时间：2019/01/08 Alzheimer's disease  depression  multitarget-directed ligand  ChE inhibition  5-HT1A agonist  5-HT reuptake inhibition   Tying up tranylcypromine: Novel selective histone lysine specific demethylase 1 (LSD1) inhibitors 期刊论文 EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2017, 卷号: 141, 页码: 101-112 作者:  Ji, Yue-Yang;  Lin, Sen-Dong;  Wang, Yu-Jie;  Su, Ming-Bo;  Zhang, Wei 收藏  |  浏览/下载：19/0  |  提交时间：2019/01/08 Tranylcypromine  LSD1  Stereoselective cyclopropanation  Chiral synthesis  MAO-A  MAO-B