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上海药物研究所 [11]
过程工程研究所 [4]
北京大学 [3]
西安交通大学 [3]
中国科学院大学 [3]
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期刊论文 [35]
发表日期
2016 [35]
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Deep Phosphoproteomic Measurements Pinpointing Drug Induced Protective Mechanisms in Neuronal Cells
期刊论文
FRONTIERS IN PHYSIOLOGY, 2016, 卷号: 7
作者:
Yu, Chengli
;
Gao, Jing
;
Zhou, Yanting
;
Chen, Xiangling
;
Xiao, Ruoxuan
收藏
  |  
浏览/下载:28/0
  |  
提交时间:2019/01/08
phosphoproteomics
Alzheimer's disease
drug effect
mass spectrometry
neutronal cells
A scFv antibody targeting common oligomeric epitope has potential for treating several amyloidoses
期刊论文
SCIENTIFIC REPORTS, 2016, 卷号: 6, 期号: NOV, 页码: 36631
作者:
Zha, Jun
;
Liu, Xiang-meng
;
Zhu, Jie
;
Liu, Shu-ying
;
Lu, Shuai
收藏
  |  
浏览/下载:26/0
  |  
提交时间:2016/12/26
Acetylcholinesterase-independent protective effects of huperzine A against iron overload-induced oxidative damage and aberrant iron metabolism signaling in rat cortical neurons
期刊论文
ACTA PHARMACOLOGICA SINICA, 2016, 卷号: 37, 期号: 11, 页码: 1391-1400
作者:
Tao, Ling-xue
;
Huang, Xiao-tian
;
Chen, Yu-ting
;
Tang, Xi-can
;
Zhang, Hai-yan
收藏
  |  
浏览/下载:17/0
  |  
提交时间:2019/01/08
Alzheimer's disease
huperzine A
iron
reactive oxygen species
mitochondria dysfunction
acetylcholinesterase
Protein kinase C controls lysosome biogenesis independently of mTORC1
期刊论文
NATURE CELL BIOLOGY, 2016, 卷号: 18, 期号: 10, 页码: 1065-1077
作者:
Li, Yang
;
Xu, Meng
;
Ding, Xiao
;
Yan, Chen
;
Song, Zhiqin
收藏
  |  
浏览/下载:60/0
  |  
提交时间:2016/12/21
Small molecule lx2343 ameliorates cognitive deficits in ad model mice by targeting both amyloid beta production and clearance
期刊论文
Acta pharmacologica sinica, 2016, 卷号: 37, 期号: 10, 页码: 1281-1297
作者:
Guo, Xiao-dan
;
Sun, Guang-long
;
Zhou, Ting-ting
;
Xu, Xin
;
Zhu, Zhi-yuan
收藏
  |  
浏览/下载:38/0
  |  
提交时间:2019/05/09
Alzheimer's disease
N-(1,3-benzodioxol-5-yl)-2-[5-chloro-2-methoxy(phenylsulfonyl)anilino]acetamide (lx2343)
Streptozotocin
Amyloid beta
Pi3k
Autophagy
App/ps1 transgenic mice
Cognitive deficit
Bace1
Small molecule LX2343 ameliorates cognitive deficits in AD model mice by targeting both amyloid beta production and clearance
期刊论文
ACTA PHARMACOLOGICA SINICA, 2016, 卷号: 37, 期号: 10, 页码: 1281-1297
作者:
Guo, Xiao-dan
;
Sun, Guang-long
;
Zhou, Ting-ting
;
Xu, Xin
;
Zhu, Zhi-yuan
收藏
  |  
浏览/下载:14/0
  |  
提交时间:2019/01/08
Alzheimer's disease
N-(1,3-benzodioxol-5-yl)-2-[5-chloro-2-methoxy(phenylsulfonyl)anilino]acetamide (LX2343)
streptozotocin
amyloid beta
BACE1
PI3K
autophagy
APP/PS1 transgenic mice
cognitive deficit
Alzheimer's disease-associated mutations increase amyloid precursor protein resistance to gamma-secretase cleavage and the A beta 42/A beta 40 ratio
期刊论文
CELL DISCOVERY, 2016, 卷号: 2
作者:
Xu, Ting-Hai
;
Yan, Yan
;
Kang, Yanyong
;
Jiang, Yi
;
Melcher, Karsten
收藏
  |  
浏览/下载:22/0
  |  
提交时间:2019/01/08
Alzheimer's disease
C99
gamma-secretase
familial Alzheimer disease (FAD)-linked mutations
epsilon-cleavage assay
Selenomethionine reduces the deposition of beta-amyloid plaques by modulating beta-secretase and enhancing selenoenzymatic activity in a mouse model of alzheimer's disease
期刊论文
Metallomics, 2016, 卷号: 8, 期号: 8, 页码: 782-789
作者:
Zhang, Zhong-Hao
;
Chen, Chen
;
Wu, Qiu-Yan
;
Zheng, Rui
;
Liu, Qiong
收藏
  |  
浏览/下载:47/0
  |  
提交时间:2019/05/09
Platinum-coordinated graphitic carbon nitride nanosheet used for targeted inhibition of amyloid beta-peptide aggregation
期刊论文
Nano research, 2016, 卷号: 9, 期号: 8, 页码: 2411-2423
作者:
Li, Meng
;
Guan, Yijia
;
Chen, Zhaowei
;
Gao, Nan
;
Ren, Jinsong
收藏
  |  
浏览/下载:58/0
  |  
提交时间:2019/05/09
Amyloid disease
Platinum
Graphitic carbon nitride nanosheet
Photooxygenation
Amyloid beta-peptide (a beta) inhibitors
Design, synthesis and biological evaluation of novel chiral oxazino-indoles as potential and selective neuroprotective agents against A beta(25-35)-induced neuronal damage
期刊论文
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2016, 卷号: 26, 期号: 15, 页码: 3765-3769
作者:
Chen, Jing
;
Tao, Ling-Xue
;
Xiao, Wei
;
Ji, Sha-Sha
;
Wang, Jian-Rong
收藏
  |  
浏览/下载:24/0
  |  
提交时间:2019/01/08
Oxazino-indoles
Oxa-Pictet-Spengler reaction
Neuroprotective agent
Alzheimer's disease
SAR
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